Takeda, Amylin to Develop Obesity Drugs in Possible $1 Billion Agreement Nov 2, 2009
The best-selling weight-loss drug, Roche Holding AGs Xenical, generated $465 million in sales last year, followed by Abbott Laboratories Meridia with sales of $41 million and generic phentermine with $40 million, according to IMS Health Inc., a market data company in Norwalk, Connecticut. The Takeda-Amylin agreement also will include other compounds being developed by the two companies, according to the statement dated Nov. 1. (Bloomberg -- Japan)
Novo's Diabetes Drug Helps Healthy People Lose Weight, Cut Blood Pressure Oct 24, 2009
Oct. 23 (Bloomberg) -- diabetes drug liraglutide helped obese, healthy volunteers lose significantly more weight and cut their blood pressure more than Roche Holding AGs obesity treatment Xenical, a study found ... 1 kilograms for those on Xenical and 2 ... GlaxoSmithKline Plc sells a form of Xenical, known chemically as orlistat, in a lower-dose, over-the-counter formulation known as Alli. (Bloomberg -- UK)
Diabetes drug 'trumps fat pill' Oct 24, 2009
One set received a placebo, the second orlistat - available by prescription as Xenical - and a third liraglutide, also known as Victoza ... " Roche, which makes Xenical, said: "Taken as an oral treatment, orlistat has been shown to significantly reduce weight when used in conjunction with healthy low fat diet and is the most widely studied drug for obesity. (BBC News -- Health)
Diabetes drug helps obese adults loss weight Oct 24, 2009
More shed pounds with liraglutide then Xenical or Alli, study shows ... Obese adults may shed more weight with the diabetes drug liraglutide than with the weight-loss drug orlistat (Xenical, Alli), suggests a study in The Lancet this week. (MSNBC -- Health)
Diabetes Drug Helps Obese Lose Weight Oct 24, 2009
Liraglutide, marketed as Victoza, outperformed the established anti-obesity drug orlistat, commercialized as Alli or Xenical, among 564 European volunteers, it suggests ... Liraglutide, marketed as Victoza, outperformed the established anti-obesity drug orlistat, commercialised as Alli or Xenical, among 564 European volunteers, it suggests. (Newsmax)
3 new prescription diet drugs may soon help obese Oct 22, 2009
Three prescription drugs now used to treat obesity include phentermine, which suppresses appetite; sibutramine (Meridia), which makes people feel full more quickly; and orlistat (Xenical), which keeps some dietary fat from being absorbed by the intestine. Orlistat is sold in a lower dose over-the-counter as Alli. (USA Today -- News)
Shop Talk: The latest scoop in business Sep 25, 2009
Katie448 wrote on Sep 24, 2009 4:35 AM:" Orlistat, the active ingredient in Xenical, works by preventing the digestion and absorption of a portion of fat from your diet. Our intestines produce enzymes called lip ases whose function is to breakdown fat molecules into its simplest form so that it can be absorbed into the body. Xenical Orlistat attaches itself to the lipases (produced primarily by the pancreas) and prevents them from breaking down some of the fat (about one-third). The unabsorbed... (Gaylord Herald Times, MI)
Glaxo Defends Safety of Weight Loss Drug Alli Sep 12, 2009
However, Glaxo has spent the last two weeks on damage control after the Food and Drug Administration said it was probing more than 30 reports of liver damage in patients taking alli and Xenical, the prescription version of the drug. Glaxo executives say sales of alli dropped 10 percent after the Aug. 24 announcement, even though the FDA stressed it had established no direct link between the drug and liver problems. (ABC News -- Wire)
Rise In Weight-loss Drugs Prescribed To Combat Childhood Obesity Sep 4, 2009
More than three quarters of those included in the study received prescriptions for orlistat, also known as Xenical or Alli. Orlistat has been approved for children as young as 12 in the US, but only for adults in the UK. Most patients given orlistat stopped using it very quickly, on average after just three months, and therefore would have been unlikely to see any benefit. (Science Daily)
FDA looking into liver problems with GlaxoSmithKline weight-loss drug Alli Aug 30, 2009
markets the drug at prescription strength under the name Xenical ... The FDA says that at this point, people taking Xenical or Alli should continue to do so. (Raleigh Triangle Business Journal, NC)
Obesity drug fears investigated Aug 26, 2009
It is also available on prescription as Xenical. Clinical trials suggest adding orlistat to a reduced-calorie, lower-fat diet, can help people lose 50% more weight than dieting alone. (BBC News -- Health)
FDA Investigating Weight-Loss Drug Over Reports of Liver Damage Aug 26, 2009
Orlistat is available in the United States, both as a prescription product (Xenical) and as an over-the-counter medication (Alli) ... In 2006, the consumer advocacy group Public Citizen petitioned the FDA to remove Xenical from the U.S. market, not because of liver-related issues but because it might increase the risk of aberrant crypt foci, believed to be precursors to colon cancer. (Atlanta Journal-Constitution -- Health)
Aussies will struggle at Olympics Aug 26, 2009
THE weight-loss drug Xenical is under investigation by the US drug watchdog, which has received 32 reports of patients suffering serious liver problems. Copyright 2009 News Limited. (Yahoo News -- Swimming)
Weight Loss and B12 Shots Jun 30, 2009
Xenical (a lower dose equivalent is now found OTC). Ephedra (banned OTC but may be prescribed if followed by a physician). (Suite101.com)
FDA Releases List of Potential Drug Risks Jun 6, 2009
Other drugs listed included orlistat, a weight-loss drug that Roche Inc. sells as the prescription product Xenical and GlaxoSmithKline Plc sells as the over-the-counter drug Alli ... Roche spokesman Terry Hurley, commenting on the listing of Xenical, said available data "does not suggest that orlistat is causally related" to liver problems, noting that obesity itself is a risk factor for liver injury. (Newsmax)
FDA: Studying Safety of Diet Drugs Alli, Xenical Jun 5, 2009
WASHINGTON -(Dow Jones)- The Food and Drug Administration is conducting a safety review of weight-loss drugs Alli and Xenical and looking at whether the drugs are linked to liver problems ... Alli is an over-the-counter weight loss drug by GlaxoSmithKline PLC (GSK) and Xenical is the prescription strength version of the same drug made by Roche. (SmartMoney)
Novo Nordisk postpones pre-launch physician training for liraglutide Apr 29, 2009
He added that this data includes a two year follow-up Phase IIIb study measuring calcitonin levels from the LEAD 3 liraglutide monotherapy study; the LEAD 2 liraglutide + metformin vs sulfonylurea study; a six month study of liraglutide vs exenatide; and a one year study of obese patients that were given very high doses of liraglutide (3mg) compared with placebo and orlistat (Xenical). The long term clinical data shows absolutely no tendency of an increase of calcitonin with... (FT.com -- Markets)
A Little Flab May Cut Up to Four Years From Life Expectancy, Study Shows Mar 19, 2009
Most of that went for purchases of Meridia, made by Abbott Park, Illinois-based and Swiss-based Xenical and Alli from London-based , Wong said. Theres a tremendous need and desire for an effective and safe weight-loss drug out there, and the potential market is well into the billions, Wong said in a telephone interview from London. (Bloomberg -- Canada)
Weight-Loss Drug May Not Inspire Diet Change Feb 26, 2009
Orlistat, sold under the prescription name Xenical, aids weight loss by blocking the absorption of dietary fat in the intestines. People on the drug are advised to limit their fat intake to no more than 30 percent of their daily calories. (MEDLINEplus)
Weight Loss Improves Fatty Liver Disease, Researchers Find Feb 20, 2009
The finding comes from a study of the diet drug orlistat (also known as Xenical and Alli), which did not itself improve liver disease. See also. (Science Daily)
