Blood Pressure Drug May Not Ease Irregular Heartbeat Jun 14, 2009
Despite earlier promise, valsartan fails to deliver against atrial fibrillation, researchers say ... WEDNESDAY, April 15 (HealthDay News) -- The blood pressure drug valsartan may not prevent episodes of a dangerous abnormal heart rhythm called atrial fibrillation, an Italian study finds ... Earlier research had suggested that valsartan (Diovan) might reduce the occurrence of atrial fibrillation, a faulty heartbeat that can lead to the formation of clots that can cause heart attack or stroke. (MEDLINEplus)
New treatment for heart failure approved by Health Canada Mar 25, 2008
Affecting more than 400,000 Canadians, HF has a greater risk of death than most cancers DORVAL, QC, March 25 /CNW/ - Health Canada has approved a leading high blood pressure medicine Diovan(*) (valsartan) to treat chronic heart failure (HF) in patients who cannot tolerate angiotensin-converting-enzyme (ACE) inhibitors, a common type of heart failure therapy ... "The approval of Diovan(*) is welcome news for this patient population who require additional options to improve survival." The approval... (Canada Newswire)
U.S. Clears Novartis' Youth High Blood Pressure Drug Dec 5, 2007
The drug, also known by its generic name valsartan, is an angiotensin receptor blocker. The company said research suggests that nearly 5 percent of children and adolescents in the United States may have high blood pressure. (MEDLINEplus)
Senior Subjects: Studies give hope for Alzheimers treatment Nov 20, 2007
The blood pressure drug valsartan (Diovan), now being used by many of us, seems to work to prevent the formation of beta-amyloid protein clumps in the brains (of mice not men, at this point). According to Giulio Maria Pasinetti of Mt. Sinai School of Medicine in New York, the next step needs to be clinical studies to see if the same effect can be obtained in humans. (Lincoln Journal, MA)
Hypertension Drugs May Prevent Alzheimer's Oct 28, 2007
Valsartan (sold as Diovan). Losartan (sold as Cozaar). (CBS News)
Blood Pressure Drug Might Work Against Alzheimer's Oct 27, 2007
THURSDAY, Oct. 25 (HealthDay News) -- The blood pressure drug valsartan shows the ability to reduce Alzheimer's disease-like symptoms in mice, researchers report. The potential value of valsartan, marketed as Diovan, emerged from a screening program that started with 55 high blood pressure drugs, said study author Dr. Giulio Maria Pasinetti, a professor of psychiatry and neurosciences at Mount Sinai School of Medicine in New York City ... "With screening in vivo [animal studies], we came up with... (MEDLINEplus)
Anti-Hypertensive Drugs May Prevent Alzheimers Disease Oct 27, 2007
In this new study, Dr. Pasinetti reports that mice genetically determined to develop Alzheimers disease beta-amyloid production and subsequent cognitive deterioration, significantly benefit from the treatment with the anti-hypertensive agent Valsartan, found to pharmacologically prevent beta-amyloid production in the brain even when delivered to Alzheimer disease mice at doses 3-4 fold lower than the minimal equivalent dose prescribed for the treatment of hypertension in humans. Other... (Newsmax)
Hypertension Drugs May Prevent and Treat Alzheimers, Study Finds Oct 27, 2007
One drug, Valsartan, was given to Alzheimer s diseased mice, at a three or four times lower than the normal dosage for humans, and the drug still prevented further production of this blockage in the brain. The effectiveness of hypertension drugs in preventing this blockage in the brain may help identify future treatments that can prevent cognitive deterioration and dementia in Alzheimer s patients, according to researchers. (FOX News)
E-911 board members should reconsider positions Oct 13, 2007
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Heart Damage Can Be Reversed with Early Treatment Aug 29, 2007
During the first six months of the study, 38 subjects received a placebo, and the other 38 subjects took 160mg of Valsartan, a drug that blocks a hormone that is detrimental to the blood vessels and the heart. During the next six months, both groups took Valsartan ... At the 12-month mark -- after both groups were taking the drug -- every patient showed better Rasmussen Disease Scores, effectively demonstrating that Valsartan can slow progression and even reverse early cardiovascular disease in... (Science Daily)
Novartis wins extension on high blood-pressure drug Aug 10, 2007
Diovan, or valsartan, has been granted pediatric exclusivity by the U.S. Food and Drug Administration based on studies conducted with children with high blood pressure. This action extends marketing exclusivity associated with the valsartan compound patent by six months to September 2012. (International Herald Tribune -- Business)
our opinion: Recent events spotlight previously discussed concerns Jul 31, 2007
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Lotus Pharmaceuticals Releases Catalog of Current and Future Drugs Jul 25, 2007
Valsartan Capsules for the treatment of medium and critical degree high blood pressure and coronary heart disease, with annual sales estimated at $12 million ... Valsartan Dropping Pills, a patented medicine exclusively produced by our company for the treatment of medium and critical degree essential hypertension, with forecasted annual sales of $20 million. (Primezone Releases)
Two Drugs Better Than One In Lowering Blood Pressure Jul 24, 2007
The combination of aliskiren and valsartan at maximum recommended doses provides significantly greater reductions in blood pressure than does monotherapy with either agent alone in patients with hypertension (high blood pressure), and the tolerability profile of the combined treatment is similar to the two-single agent treatments ... Both aliskiren and valsartan are inhibitors of the renin system of the kidneys ... The first group received once-daily aliskiren 150mg, the second once daily... (Science Daily)
New Drug Combo Fights High Blood Pressure Jul 24, 2007
The two drugs used in the study were valsartan (Diovan), which blocks the cell receptors on which angiotensin acts, and aliskiren (Tekturna), which blocks the molecular pathway for production of angiotensin II. ... "These findings provide a clear rationale for further studies to investigate the potential effects of long-term treatment with the combination of aliskiren and valsartan, and combinations of aliskiren and other angiotensin receptor blockers, on possible benefits beyond treating... (MEDLINEplus)
Tekturna & Diovan together provide additive blood pressure reductions Jul 23, 2007
Results from a new study involving high blood pressure patients taking Tekturna (aliskiren) and Diovan (valsartan) were published in The Lancet. The study, presented earlier this year at the American College of Cardiology congress, shows this combination provides patients with greater blood pressure reductions than either medicine alone and demonstrated tolerability comparable to placebo. (SpiritIndia)
ACE Plus ARB Found to Equal Lower Blood Pressures Jul 21, 2007
Dual inhibition of the renin system with the maximum recommended doses of aliskiren (Tekturna), an orally active direct renin inhibitor, and valsartan, an angiotensin receptor blocker (ARB), reduced mean sitting systolic and diastolic pressures significantly more than did either drug alone, found Suzanne Oparil, M.D., of the University of Alabama at Birmingham, and international colleagues ... Of the patients, 437 were randomized to once-daily aliskiren at 150 mg, 455 to valsartan at 160 mg, 446... (MedPage Today)
Exforge(R) Receives Final US Approval as New and Powerful Treatment Option for Patients With High Blood Pressure Jun 21, 2007
Exforge is the first medicine of its kind to combine the active ingredients of an angiotensin receptor blocker -- Diovan(R) (valsartan) -- and a calcium channel blocker -- Norvasc(R)(*) (amlodipine) -- with the convenience of a single, once-daily tablet(1,2,3) ... In two further clinical trials, Exforge demonstrated superior blood pressure lowering efficacy in patients uncontrolled when taking either valsartan or amlodipine alone, the two high blood pressure drugs combined in Exforge(1) ... It... (PR Newswire)
Health Highlights: April 28, 2007 Apr 29, 2007
The Novartis blood pressure-lowering drug Diovan (valsartan) showed a 39 percent decreased risk of cardiovascular events and a 40 percent drop in stroke during a 3,000-person Japanese trial, its manufacturer says ... In a statement, Novartis said the study was "terminated earlier than anticipated ... due to superior outcomes for the valsartan group over the control group.". (Forbes)
First Controlled Large-Scale Intervention Angiotensin Receptor Blocker (ARB) Trial in a Japanese Population, JIKEI HEART Study Demonstrates Significant Reduction in Blood Pressure and Protection of Organs with Valsartan Apr 27, 2007
Unprecedented Evidence for the Effectiveness of Hypertension Treatment Valsartan in Preventing Cardiovascular Events in Japanese Patients TOKYO, April 26 /Xinhua-PRNewswire/ -- The clinical outcomes of the JIKEI HEART Study, the large-scale clinical trial headed by the Jikei University School of Medicine, was today published in the internationally renowned medical journal The Lancet ... It also is the first large- scale study evaluating the benefits of the ARB, valsartan, in Japanese patients... (PR Newswire)
Lowering Blood Pressure Improves Diastolic Dysfunction In Hypertensive Patients Apr 4, 2007
According to study results presented today at the American College of Cardiology's 56th Annual Scientific Session, diastolic dysfunction improved in patients with mild hypertension when treated with the blood pressure-lowering agent valsartan, as well as with other approaches to lowering blood pressure. In this study, known as the VALIDD (The VALsartan In Diastolic Dysfunction) trial, conducted at 41 centers in the United States and Canada, researchers aimed to determine whether lowering blood... (Science Daily)
Drugs That Boost HDL Cholesterol Not Ready for Prime Time Mar 28, 2007
A final study found that a combination of aliskiren and valsartan, two drugs that work against the enzyme rennin, were more effective in lowering blood pressure than either of the compounds alone. This was the first study to assess the drugs together. (MEDLINEplus)
Low libido from blood pressure drug? Jan 16, 2007
Some physicians report that ACE inhibitors (such as enalapril or lisinopril) or ARBs (such as losartan or valsartan) may be less likely to affect sexual function. Your husband also should have his testosterone levels checked. (Newsday -- Health)
Husband's loss of desireis ruining their marriage Jan 13, 2007
Some physicians report that ACE inhibitors (such as enalapril or lisinopril) or ARBs (such as losartan or valsartan) may be less likely to affect sexual function (Drugs, Vol. 65, No. 6, 2005). Your husband also should have his testosterone levels checked. (The Standard-Times, MA)
