An Autoinflammatory Disease Due to Homozygous Deletion of the IL1RN Locus Jun 4, 2009
Treatment with anakinra completely resolved the symptoms and lesions. Source Information. (New England Journal of Medicine)
An Autoinflammatory Disease with Deficiency of the Interleukin-1–Receptor Antagonist Jun 4, 2009
Response to empirical treatment with the recombinant interleukin-1 receptor antagonist anakinra in the first patient prompted us to test for the presence of mutations and changes in proteins and their function in interleukin-1 pathway genes including IL1RN. ... Patients treated with anakinra responded rapidly. (New England Journal of Medicine)
Treating Gum Disease Helps Rheumatoid Arthritis Sufferers May 30, 2009
21, 2009) New research supports a modest beneficial effect of anakinra for rheumatoid arthritis patients, but warns against potential risks for serious infections and its use with other biologic. . (Science Daily)
UCB's CIMZIA(R) (certolizumab pegol) Approved by the U.S. FDA for Adult Patients Suffering From Moderate to Severe Rheumatoid Arthritis May 14, 2009
An increased risk of serious infections has been seen in clinical trials of other TNF blocking agents used in combination with anakinra or abatacept ... Therefore, the combination of CIMZIA with anakinra, abatacept, rituximab, or natalizumab is not recommended. (PR Newswire)
Type Of Rheumatoid Arthritis Medication May Be Associated With Increased Risk For Shingles Mar 1, 2009
The researchers analyzed data from patients who began treatment with adalimumab or infliximab (monoclonal anti TNF- antibodies), etanercept (a fusion protein), the monotherapeutic agent anakinra, or when patients changed conventional disease-modifying anti-rheumatic drug (DMARD). Treatment, clinical status and adverse events were assessed by rheumatologists at fixed points during follow-up (of up to three years). (Science Daily)
New clues to healing arthritis caused by traumatic injury Feb 23, 2009
"Current treatments on the market for rheumatoid arthritist include anakinra (Kineret, an IL-1 receptor antagonist) and etanercept (Enbrel, a tumor necrosis factor blocker)," said Farshid Guilak, Ph. D., study scientist and director of the Orthopaedic Bioengineering Laboratory in the Duke Department of Surgery. (EurekAlert!)
Rheumatoid Arthritis Drugs Raise Shingles Risk Feb 19, 2009
In the latest study, researchers from the German Rheumatism Research Centre in Berlin looked at 5,040 people taking the TNF blockers infliximab (Remicade) or adalimumab (Humira), the fusion protein etanercept (Enbrel) or the monotherapeutic drug anakinra (Kineret). Although generally considered a TNF blocker, Enbrel was not put in that category for the study because it works with a slightly different mechanism than Remicade and Humira, explained the study's lead author, Dr. Anja Strangfeld, of... (MEDLINEplus)
