Tamiflu-Resistant Swine Flu Passed Person-to-Person in U.S. Oct 31, 2009
So far, almost all strains of H1N1 have responded to both oseltamivir (Tamiflu) and another antiviral, zanamivir (Relenza), while displaying resistance to amantadine, a drug in a different class. As a result, Tamiflu and Relenza have been used widely for both the prevention and treatment of H1N1. (MEDLINEplus)
Triple-combo Drug Shows Promise Against Antiviral-resistant H1N1 Oct 30, 2009
In laboratory testing, the triple combination of oseltamivir (Tamiflu), amantadine (Symmetrel) and ribavirin showed a significant capacity to stop flu-virus growth, says Mark Prichard, Ph. D, who serves on the board of directors of the International Society for Antiviral Research. (Science Daily)
Asthma and H1N1: Here's what to do Oct 29, 2009
Although most of the patients had antivirals in the hospital, they found that those who ended up in the ICU or who died tended to get antiviral drugs (such as oseltamivir, zanamivir, amantadine, and rimantadine) later than others. "If you look at the timing of it, you'll see that patients in ICU or who died were not treated within two days," she says. (CNN)
New IV Drug Fights Flu as Well as Tamiflu Sep 17, 2009
The drug cocktail contains three drugs -- amantadine, ribavirin and Tamiflu -- that are already on the market. Alone, each has lost some of its punch against the flu because of the ability of the virus to mutate. (CBS News)
Tamiflu Saves Lives of Severely Ill Flu Patients Sep 15, 2009
Two older flu drugs, amantadine and rimantadine, now have very little effect against influenza viruses. (Reporting by Julie Steenhuysen in Chicago; Editing by Maggie Fox and Eric Beech). (MEDLINEplus)
H1N1 trials to use drug cocktail Sep 14, 2009
All three of the drugs amantadine, ribavirin and Tamiflu are already on the market ... Adamas sponsored the tests using a fixed-dose mix of amantadine and ribavirin and Roche's Tamiflu. (USA Today -- News)
In Vitro Study of Adamas Pharmaceuticals' Triple Combination Antiviral Drug Therapy Shows Activity Against Drug-Resistant Influenza Viruses Sep 14, 2009
Adamas' TCAD therapy consists of a proprietary fixed-dose combination drug product (amantadine and ribavirin), to be administered adjunctively with a neuraminidase inhibitor such as Tamiflu (oseltamivir phosphate, Roche). In this study, using a scientifically accepted in vitro infection model, researchers compared amantadine, ribavirin, and oseltamivir alone and in combination against influenza A viruses that are resistant to either oseltamivir or amantadine, including novel A/H1N1 ... "These... (PR Newswire)
* Scientists say dung of the devil may help battle H1N1 Sep 13, 2009
Extracts from the plants roots, bought from a Chinese herb shop in Taipei, were more potent against the (A)H1N1 virus in lab tests than was the prescription anti-viral medicine amantadine, a Kaohsiung Medical University research team wrote in a study scheduled for publication on Sept. 25 in the ACS Journal of Natural Products ... Researchers treated some virus-infected cells with compounds extracted from the devil dung plant and others with amantadine, a generic drug ... Current strains of... (Taipei Times, Taiwan -- World Business)
Experts Keep Wary Eye on Tamiflu-Resistant Swine Flu Jul 10, 2009
Strains of the "regular" seasonal flu often become resistant to antiviral drugs but, generally speaking, antiviral resistance is less common with Tamiflu and a related antiviral drug, Relenza, than it is with two other drugs, amantadine and rimantadine, which the U.S. Centers for Disease Control and Prevention has recommended against using for seasonal flu. Tamiflu is preferred over Relenza in general because it is easier to administer, Gaglani said. (MEDLINEplus)
U.S. experts concerned about effectiveness of Tamiflu Jul 9, 2009
Strains of the "regular" seasonal flu often become resistant to antiviral drugs but, generally speaking, antiviral resistance is less common with Tamiflu and a related antiviral drug, Relenza, than it is with two other drugs, amantadine and rimantadine, which the U.S. Centers for Disease Control and Prevention has recommended against using for seasonal flu. A man leaves a school, attended by children from the five new confirmed cases of influenza A (H1N1), after collecting a box of Tamiflu in... (Xinhuanet, China)
USU scientists studying swine flu May 21, 2009
The USU researchers, who were involved in the pre-clinical development of Tamiflu, are testing that drug, as well as two others amantadine and ribavirin against the virus, both individually and combined. We already know that the triple combination is highly effective, Smee said. (Logan Herald Journal, UT)
Gilead, Roche ready with swine flu treatments May 1, 2009
Swine influenza A viruses detected in the United States and Mexico appear resistant to two antiviral drugs amantadine and rimantadine but laboratory tests indicate the viruses are sensitive to Tamiflu, also known as oseltamivir, and Relenza, which is known as zanamivir. The Tamiflu oral antiviral, approved in the U.S. to treat and prevent influenza A and B virus infection in people age one or older, is sold by Ltd., which pays sales-related royalties to Gilead. (East Bay Business Times, CA)
State officials cautious about swine flu9:52 am | (No comments posted.) Apr 29, 2009
They said the H1N1 viruses are resistant to amantadine and rimantadine. The viruses contain a unique combination of gene segments that have not been reported previously among swine or human influenza viruses in the U.S. or elsewhere, the CDC statement said. (Watertown Public Opinion, SD)
More of this story Apr 29, 2009
The virus is reportedly susceptible to four prescription anti-viral drugs: Amantadine, Rimantadine, Oseltamivir and Zanamivir. CDC acting head Richard Besser reiterated the Obama administration s call for calm and taking precautions against the swine flu (H1N1), which the CDC reports has affected people in California, Kansas, New York, Ohio and Texas. (Westerly Sun, RI)
Q&A: SYMPTOMS, CARE Apr 29, 2009
A: This strain of swine flu does appear sensitive to the antiviral drugs Relenza and Tamiflu, but not to amantadine, or Symmetrel, and rimantadine, or Flumadine, Besser said. With normal seasonal flus, if taken within the first 48 hours after symptoms appear, antivirals can help people recover a day or two sooner. (USA Today)
U.S. Declares Public Health Emergency in Response to Swine Flu Apr 28, 2009
The viruses found in the United States are resistant to two antiviral medications -- amantadine and rimantadine -- but are susceptible to the antivirals oseltamivir (Tamiflu) and zanamivir (Relenza), Schuchat said. Schuchat said steps were already being taken to devise a vaccine against this strain of swine flu, although the process takes time. (MEDLINEplus)
Swine Flu FAQ Apr 28, 2009
The swine flu is resistant to two common drugs Amantadine and Rimantadine. The H1N1 swine flu viruses are very different from human H1N1 viruses. (The Star Online, Malaysia)
Is Swine Flu Really a Major Danger? Apr 28, 2009
This strain is resistant to the old antiviral drugs amantadine and rimantadine, but the same goes for most new influenza strains. Oseltamivir (Tamiflu) and zanamivir (Relenza) still work, though they need to be taken early in the course of the illness. (Suite101.com)
South Dakota officials concerned by swine flu1:36 pm | (No comments posted.) Apr 28, 2009
They said the H1N1 viruses are resistant to amantadine and rimantadine. South Dakota's state epidemiologist, Lon Kightlinger, and South Dakota Health Secretary Doneen Hollingsworth called a news conference for later Monday to discuss the situation. (Watertown Public Opinion, SD)
WHO Warns of Possible Pandemic as Mexico Seeks to Contain Swine Flu Apr 28, 2009
The viruses found in the United States are resistant to two antiviral medications -- amantadine and rimantadine -- but are susceptible to the antivirals oseltamivir (Tamiflu) and zanamivir (Relenza), Schuchat said. Swine flu is a respiratory disease of pigs caused by type A influenza. (MEDLINEplus)
Questions and answers about swine flu Apr 28, 2009
A: There are four different antiviral drugs that are licensed for use in the U.S. for the treatment of influenza: amantadine, rimantadine, oseltamivir and zanamivir. While most swine influenza viruses have been susceptible to all four drugs, the most recent swine influenza viruses isolated from humans are resistant to amantadine and rimantadine. (Honolulu Advertiser)
Swine Flu Could be the News Story of the Decade Apr 28, 2009
There are four different antiviral drugs that are licensed for use in the US for the treatment of influenza: amantadine, rimantadine, oseltamivir and zanamivir. While most swine influenza viruses have been susceptible to all four drugs, the most recent swine influenza viruses isolated from humans are resistant to amantadine and rimantadine. (Alva Review Courier, OK)
Swine flu threat calls for precaution, preparation Apr 28, 2009
It is resistant to the antiviral medications amantadine and rimantadine, though. The federal government has 50 million treatment courses of Tamiflu and Relenza in the nation's Strategic National Stockpile, Napolitano said. (USA Today -- Money)
Flu Strikes a Milder Blow This Season Apr 10, 2009
The drug Tamiflu (oseltamivir), routinely prescribed to people with the flu, is resistant to this year's H1N1 strain, and the H3N2 flu strain is resistant to two other antivirals, rimantadine (Flumadine) and amantadine (Symmetrel). Although 146 million doses of flu vaccine were distributed this season, the number of people who were actually vaccinated is unknown, Fry said. (MEDLINEplus)
Predictors and correlates for weight changes in patients co-treatedwith olanzapine and weight mitigating agents; a post-hoc analysis Mar 29, 2009
Included were 158 patients with schizophrenia or bipolar disorder and a body mass index (BMI) [greater than or equal to]25 kg/m2 who had received olanzapine treatment in combination with nizatidine (n=68), sibutramine (n=42), or amantadine (n=48). Individual patients were analyzed for categorical weight loss [greater than or equal to]2 kg and weight gain [greater than or equal to]1 kg. Variables that were evaluated as potential predictors of weight outcomes included baseline patient... (BioMed Central)
Drug-resistant flu strains throwing doctors a curve Mar 23, 2009
Amantadine and rimantadine: Effective only against H1N1. (Trade name for amantadine is Symmetrel and for rimantadine is Flumadine, but both are available as generics ... In recent years, because of rising concern about the potential for a flu pandemic, governments around the world have been stockpiling millions of doses of Tamiflu, along with smaller amounts of Relenza and older antivirals, amantadine and rimantadine. (USA Today -- News)
Resistance to Tamiflu Growing Mar 4, 2009
In 2006, the CDC issued a recommendation against using two other flu drugs, amantadine and rimantadine, owing to resistant strains of influenza B and H3. Those drugs work by a different mechanism than Tamiflu and the other drug in its class, Relenza (zanamivir). (MEDLINEplus)
Resistance to flu drug widespread in U.S.: study Mar 4, 2009
Flu already resists two older drugs, rimantadine and amantadine. There is no indication the two other types of season flu now circulating, H3N2 and influenza B, resist the effects of Tamiflu. (Yahoo News -- Top Stories)
Respiratory illnesses finally make way to area Feb 26, 2009
Favila prescribes Relenza alone or Tamiflu with Amantadine or Rimantadine. The doctor is in. (The Pantagraph newspaper)
