Therapeutic Value of Reishi Nov 1, 2009
Reishi inhibits platelet aggregation, a property that is probably due to its adenosine content. (Hobbs C. Medicinal Mushrooms. (Suite101.com)
How Are Nutrients Incorporated Into... Oct 30, 2009
Catabolic reactions involve breaking down molecules like glucose and fatty acids into usable forms of energy like adenosine triphosphate (ATP). In contrast, anabolic reactions involve the construction of more complex molecules from simpler ones. (Suite101.com)
Painful erection may soon be history Oct 27, 2009
A research team from United States and China suggests adenosine deaminase enzyme therapy could successfully prevent or treat penile fibrosis in men with priapism ... "Hopefully this discovery can yield new drugs that relieve the excitatory signals sent by adenosine so that these men to get some relief," Weissmann added ... During the study researchers used two priapism animal models to determine the role of increased adenosine in penile fibrosis. (India Times, India)
That '4 hour erection': new discovery may help prevent a complication of priapism Oct 27, 2009
New research in the FASEB Journal suggests adenosine deaminase enzyme therapy could successfully prevent or treat penile fibrosis in men with priapism ... That's because researchers from the United States and China show that the enzyme adenosine deaminase may prevent priapism from progressing to penile fibrosis, a condition associated with the build up of scar tissue and eventual impotence ... Adenosine deaminase, which breaks down adenosine, is already used in humans as a treatment for a rare... (EurekAlert!)
Bedtime story was court order Oct 24, 2009
Instead of rushing into the HealthPoint gym, clashing with each other in workouts, the Celtics are rolling over and allowing adenosine to dissipate, cognitive functions to rejuvenate, protein synthesis to generate. I love it, guard Eddie House said. (Boston Globe)
What is in Chocolate? Oct 24, 2009
com by Josh Clark, Caffeine affects dopamine and adenosine receptors in the brain; causing the brain to release chemicals that produce a pleasure response. According to an article in MensHealth. (Suite101.com)
SCID Kids Leading Healthy, Normal Lives 25 Years After 'Bubble Boy' Oct 14, 2009
In addition, about 10 percent had some sort of developmental delay and about 20 percent had attention deficit disorder, often due to the lack of an enzyme called adenosine deaminase, one of the causes of SCID. Other conditions appearing in a minority of the patients include diarrhea, rashes and HPV infection. Some of the conditions appeared more frequently in certain SCID subtypes than others. (Science Daily)
Breast Milk Should Be Drunk At The Same Time Of Day That It Is Expressed Oct 3, 2009
The scientists looked for three nucleotides in breast milk (adenosine, guanosine and uridine), which excite or relax the central nervous system, promoting restfulness and sleep, and observed how these varied throughout a 24-hour period. The milk, collected from 30 women living in Extremadura, was expressed over a 24-hour period, with six to eight daily samples. (Science Daily)
Eloise Giblett; research kept donated blood safe Sep 26, 2009
Before the emergence of AIDS, Dr. Giblett discovered the first known immunodeficiency disease, called adenosine deaminase deficiency. An inherited metabolic disorder, it is caused by a lack of the ADA enzyme, preventing the normal maturation of lymphocytes, a component of the human immune system, and making the body more vulnerable to disease. (Boston Globe)
Link Between Protein And Lung Disease Found Sep 17, 2009
The study stems from research in Blackburn's laboratory involving a signaling molecule named adenosine, which can orchestrate the process of inflammation in wound healing. Adenosine can also activate a cell surface receptor associated with COPD named A2B and produce osteopontin ... The study is titled "Adenosine and osteopontin contribute to the development of chronic obstructive pulmonary disease." Other contributors from the Department of Biochemistry and Molecular Biology were graduate... (Science Daily)
Comprehensive Cardiac CT Scan May Give Clearer Picture Of Significant Heart Disease Sep 16, 2009
Participants first had a cardiac CT taken while receiving an infusion of adenosine, which produces physiologic stress symptoms such as elevated heart rate and blood pressure. When vital signs returned to normal several minutes after the adenosine infusion, a resting cardiac CT was taken. (Science Daily)
Second-hand Smoking Results In Liver Disease Sep 14, 2009
In their study, the researchers focused on two key regulators of lipid (fat) metabolism that are found in many human cells as well: SREBP (sterol regulatory element-binding protein) that stimulates synthesis of fatty acids in the liver, and AMPK (adenosine monophosphate kinase) that turns SREBP on and off. They found that second-hand smoke exposure inhibits AMPK activity, which, in turn, causes an increase in activity of SREBP. When SREBP is more active, more fatty acids get synthesized. (Science Daily)
Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes Sep 10, 2009
Background Ticagrelor is an oral, reversible, direct-acting inhibitor of the adenosine diphosphate receptor P2Y12 that has a more rapid onset and more pronounced platelet inhibition than clopidogrel. Methods In this multicenter, double-blind, randomized trial, we compared ticagrelor (180-mg loading dose, 90 mg twice daily thereafter) and clopidogrel (300-to-600-mg loading dose, 75 mg daily thereafter) for the prevention of cardiovascular events in 18,624 patients admitted to the hospital with an... (New England Journal of Medicine)
Ticagrelor — Is There Need for a New Player in the Antiplatelet-Therapy Field? Sep 10, 2009
The thienopyridine clopidogrel, which irreversibly blocks the adenosine diphosphate (ADP) receptor P2Y12 on platelets, has become an essential component of therapy in patients with acute coronary syndromes, because it significantly improves the outcomes. 1 However, clopidogrel has at least three drawbacks: delayed onset of action, large interindividual variability in platelet response, and irreversibility of its inhibitory effect on platelets (Figure 1). (New England Journal of Medicine)
Prasugrel in Clinical Practice Sep 3, 2009
The new drug is the latest addition to a class of agents that inhibit the platelet adenosine diphosphate (ADP) receptor, preventing initial platelet activation and consequent platelet aggregation a mechanism that has represented a major advance in the treatment of atherothrombotic diseases. 1 Indeed, the use of the thienopyridine ticlopidine in combination with aspirin to inhibit platelet aggregation facilitated the widespread use of coronary-artery stenting. (New England Journal of Medicine)
Regulation of cerebrospinal fluid production by caffeine consumption Sep 3, 2009
In contrast to the chronic effects, acute treatment with caffeine decreased the production of CSF, suggesting 'effect inversion' associated with caffeine, which was mediated by increased expression of the A1 adenosine receptor, in the choroid plexus of rats chronically treated with caffeine. The involvement of the A1 adenosine receptor in the effect inversion of caffeine was further supported by the induction of ventriculomegaly and Na+, K+-ATPase, in A1 agonist-treated rats ... The results of... (BioMed Central)
Video: Phase III Head to Head Trial Showed Ticagrelor Reduced Cardiovascular Death and Heart Attacks Over Clopidogrel in Acute Coronary Syndromes Patients Aug 30, 2009
Ticagrelor (BRILINTA(TM)) is an investigational oral antiplatelet treatment for ACS. BRILINTA (ticagrelor) is the first reversibly binding oral adenosine diphosphate (ADP) receptor antagonist. It selectively inhibits P2Y12, a key target receptor for ADP. ADP receptor blockade inhibits the action of platelets in the blood, reducing recurrent thrombotic events. (PR Newswire)
Blood Not So Simple: Controversial Hemoglobin Substitutes on Life Support Aug 29, 2009
Congressman steps in HemoBioTech, one of the few companies that is still in business since the 2008 FDA meeting, may have an ally in , who earlier this month wrote an open letter to fellow House of Representatives members encouraging them to support funding for a "promising, cost-effective" blood substitute using hemoglobin modified with adenosine. "Fully 10 percent of [HIV and AIDS] infections and deaths can be prevented with a viable blood substitute that can deliver oxygen throughout the body... (Scientific American)
Parkinson's Disease: When Cells Run Out Of Fuel Aug 26, 2009
The relevance of mitochondria to the loss of neurons seems plausible after all, mitochondria supply the cells with energy in form of adenosine triphosphate and play a substantial role in the regulation of cell death ... Loss of Parkin or PINK1 function impairs the morphology and activity of mitochondria, which then produce less adenosine triphosphate. (Science Daily)
Click to read: Does Blue Food Dye Prevent Paralysis? Jul 29, 2009
Ashton explained that, when a spinal cord injury occurs, a molecule called adenosine triphosphate, also known as ATP, is released in high amounts. The ATP molecules then bind to receptors that trigger irreversible cell death, which then leads to swelling. (CBS News -- Early Show)
Psychotherapy Of Depression Changes Biological Parameters? Jul 7, 2009
The cyclic adenosine monophosphate response element-binding proteins (CREB) and their interaction with brain-derived neurotrophic factor (BDNF) are essential elements in signal transduction pathways important for cellular resilience and neuroplasticity. They play a decisive role in the concept of altered neuroplasticity in major depression. (Science Daily)
Opinion: Taking a jog with a cup of coffee Jul 5, 2009
The drugs primary use is as an adenosine inhibitor. Adenosine is a nucleoside that fronts your bodys neurological urge to sleep ... Prolonged consumption leads to an expanded amount of adenosine receptors in the brain the bodys way of overcoming the pesky caffeine thats blocking its efforts to tell you to go to sleep and it can gradually become more difficult to receive the beneficiary side effects of the drug over time as the brain becomes partially immune. (Carlisle Sentinel, PA)
Protein Regulates Movement Of Mitochondria In Brain Cells Jun 17, 2009
Mitochondria are cellular power plants that generate most of the cell's supply of adenosine triphosphate (ATP), which is used as a source of chemical energy. While mitochondria are present in all of the body's cells, some cells because of their size and purpose need to transport mitochondria to distant sites within the cell to maintain proper function. (Science Daily)
Better treatment selection and improved therapies -- key to improving prognosis in acute HF May 31, 2009
Many new agents are currently under development, said Professor Metra, which include adenosine type 1 receptors antagonists to enhance the diuretic effects of furosemide and increase renal blood flow, new vasodilators with different mechanisms of action, and new inotropic agents. "Better treatment selection and the development of new agents give us some hope that we will finally be able to improve the symptoms and prognosis of such a large patient population as that suffering from acute heart... (EurekAlert!)
Serial Monitoring With ImmuKnow(R) is Useful in the Risk Assessment of Kidney Transplant Recipients May 31, 2009
It measures the concentration of adenosine triphosphate (ATP) released from CD4 cells following cell stimulation. The ImmuKnow test is a qualitative assay and does not directly quantify the level of immunosuppression. (PR Newswire)
Phosphate Balance In Higher Organisms Elucidated May 18, 2009
The enzyme investigated - VTC (vacuolar transporter chaperone) - makes use of the universal energy carrier ATP (adenosine triphosphate) within cells for the gradual synthesis of phosphate chains. A depot, which the organism can resort to under stress conditions, is thus created. (Science Daily)
How to Build Nanotech Motors May 7, 2009
All these motors, as well as those that power muscle contractions and the corkscrew motion of bacterial flagella, are based on the same principle: they convert chemical energy usually stored as adenosine triphosphate, or ATP into mechanical energy. And all exploit catalysts, compounds able to facilitate chemical reactions such as the breakdown of ATP. Researchers are now making exciting progress toward building arti-ficial nanomotors by applying similar principles. (Scientific American)
New Insight Into An Old Reaction: Adenylylation Regulates Cell Signaling Apr 18, 2009
"Although Fic domains are found in proteins from bacteria to humans, their activity has remained unknown until recently, when Yarbrough et al. (Science, 2009, v. 323, p. 269) reported a Fic domain containing protein that catalyzed an adenosine monophosphate (AMP) modification on threonine residues of Rho GTPases," explains Dr. Dixon. Rho GTPases regulate multiple key signaling pathways in mammalian cells. (Science Daily)
Some Orthodontic Appliances Are More Prone To Bacteria Apr 17, 2009
The OHSU team also found that a biochemical technique measuring ATP- (adenosine triphosphate-) driven bioluminescence could be a useful chair-side tool in the rapid quantification of oral bacteria and in the assessment of oral hygiene during orthodontic treatment. See also. (Science Daily)
Wrinkle Cream Is Next To Godliness Apr 16, 2009
Easeamine, and the Carmelites' path toward selling it, started in an unlikely place: a lab at the University of Massachusetts Medical School, where Dr. James Dobson Jr. has spent years studying a biological substance known as adenosine. While researching how the heart ages, Dobson and colleague Michael Ethier discovered several years ago that adenosine a natural substance that's plentiful in older hearts triggers the skin's dermis to produce more elastin and collagen. (San Francisco Chronicle -- Weird News)
OHSU School of Dentistry finds some orthodontic appliances are more prone to bacteria Apr 15, 2009
The OHSU team also found that a biochemical technique measuring ATP- (adenosine triphosphate-) driven bioluminescence could be a useful chair-side tool in the rapid quantification of oral bacteria and in the assessment of oral hygiene during orthodontic treatment. The findings are published in the April 2009 issue of the American Journal of Orthodontics and Dentofacial Orthopedics, one of the leading peer-reviewed orthodontia journals. (EurekAlert!)
New Therapeutic Strategy Could Target Toxic Protein In Most Patients With Huntington's Disease Apr 13, 2009
The genetic code is written with four letters, A, C, T, and G, which stand for the four nucleotides, adenosine, cytidine, thymidine, and guanosine. The pattern of these nucleotides dictates which protein is encoded by a given gene. (Science Daily)
Prune Juice Not Necessary: New Research Should Make Bowel Movements Easier Apr 12, 2009
The research involved two groups of mice, focusing on a type of receptor also present on human nerves in the gut (a type of adenosine receptor). The first group of mice had normal adenosine receptors on these nerves and normal bowel movements ... The second group of mice completely lacked these adenosine receptors and showed familiar signs of constipation. (Science Daily)
Caffeine May Lessen Exercisers' Muscle Pain Apr 10, 2009
In theory, caffeine may limit muscle pain by blocking the activity of a chemical called adenosine. Adenosine is released as part of the inflammatory response to injury and can activate pain receptors in body cells. (MEDLINEplus)
Coffee can lessen the pain of exercise, new research finds Apr 1, 2009
Caffeine works on a system in and spinal cord (the adenosine neuromodulatory system) that is heavily involved in , says University of Illinois kinesiology and community health professor Robert Motl. And since caffeine blocks adenosine, the biochemical that plays an important role in energy transfer and thus , he speculated that it could reduce pain. (MSNBC -- Health)
Caffeine Reduces Pain During Exercise Apr 1, 2009
Tuesday, March 31, 2009. SIGN UP FOR FREE NEWS ALERTS. (Newsmax)
A little java makes it easier to jive, researcher says Apr 1, 2009
Early in his research, he became aware that "caffeine works on the adenosine neuromodulatory system in the brain and spinal cord, and this system is heavily involved in nociception and pain processing." Since Motl knew caffeine blocks adenosine from working, he speculated that it could reduce pain. A number of studies by the U. of I. professor support that conclusion, including investigations considering such variables as exercise intensity, dose of caffeine, anxiety sensitivity and gender. (EurekAlert!)
To Fight Drug Addiction, Researchers Target The Brain With Nanoparticles Mar 26, 2009
(May 15, 2008) Researchers have identified a factor that may contribute towards the development of heroin addiction by manipulating the adenosine A2A receptor, which plays a major role in the brain's 'reward. (Sep. (Science Daily)
Avalon to appeal Nasdaq delisting Mar 18, 2009
Clinical Data (NASDAQ: CLDA) paid $11 million to acquire Adenosine Therapeutics LLC and has been spending money on development of its experimental antidepressant drug. Avalon has said it will keep its operations and remaining staff in Germantown after the merger. (Washington Business Journal, DC)
Hildreth on Health: Who is depressed and why? Mar 1, 2009
Natural components that may be added to either supporting the utilization of existing neurotransmitters or aiding in natural production of deficient neurotransmitters may be SAM-e, a natural substance that the body can produce from the essential amino acid methionine and adenosine triphosphate that is found in all cells of the body. St. Johns wort is an herb that some of you may be familiar with. (Green Valley News & Sun, AZ)
UT Southwestern researchers identify molecule that helps the sleep-deprived to mentally rebound Feb 24, 2009
Working with mice, they found that a molecule called an adenosine receptor is necessary for sleep-restricted animals to attain adequate levels of slow-wave activity in the brain once normal sleep resumes ... "We need to have our adenosine receptors intact to do that." ... Adenosine receptors on nerve cells, including brain cells, are akin to docking points for the molecule adenosine. (EurekAlert!)
JCI online early table of contents: Feb. 16, 2009 Feb 17, 2009
METABOLIC DISEASE: Adenosine signaling links alcohol and liver disease ... However, Bruce Cronstein and colleagues, at New York University School of Medicine, New York, have now established that adenosine, which is a product of the breakdown of ethanol (the alcoholic component of alcoholic beverages), has a central role in alcohol-induced fatty liver in mice ... Further analysis revealed that adenosine mediated its effects in mice via two proteins, the adenosine A1 and A2B receptors. (EurekAlert!)
Fight winter energy drain with lifestyle changes Feb 11, 2009
Caffeine also has been shown to block adenosine receptors; getting enough adenosine during the daytime is a trigger for getting to sleep at night. If you drink a cup of coffee at noon, a quarter cup s worth could still be in your system by midnight. (La Crosse Tribune, WI)
Coffee Drinkers Show Lower Dementia Risk Feb 8, 2009
For its part, caffeine may have a protective effect on brain cells because it blocks receptors for a chemical called adenosine, which has depressant effects in the central nervous system. More research is needed to determine whether coffee is truly protective, but for now, Eskelinen said, "those people who have been drinking coffee can still do so in good conscience.". (MEDLINEplus)
Performance Lab Feb 8, 2009
Many athletic events involve short bursts of maximal effort utilizing ATP (adenosine triphosphate) and CP (creatine phosphate) as energy. The availability of ATP and CP stores and the ability to rapidly breakdown glycogen is difficult to measure directly. (Airforcesports.com)
