Protective effect of transgenic expression of porcine heat shock protein 70 on hypothalamic ischemic and oxidative damage in a mouse model of heatstroke Sep 3, 2009
g., glutathione peroxidase and glutathione reductase), ATP, and HSP72 expression. Conclusion. (BioMed Central)
Delta-opioid receptors reduce oxidative injury Aug 26, 2009
We observed that, in a model of cerebral ischemia with middle cerebral artery occlusion, DOR activation increased the activity of major antioxidant enzymes, glutathione peroxidase and superoxide dismutase, and decreased malondialdehyde and nitric oxide levels in the cortex exposed to cerebral ischemia/reperfusion. In addition, DOR activation reduced caspase 3 expression, though it did not significantly affect the increase in interleukin (IL)1beta and tumor necrosis factor (TNF)alpha expression... (BioMed Central)
Sound Pharmaceuticals Receives an Office of Naval Research Award for Its Hearing Loss Research and Development Aug 20, 2009
SPI-1005, an oral form of a glutathione peroxidase mimic, is currently being tested in a Ph-II clinical trial aimed to protect and treat blast exposed active duty personnel in the Dept. of Defense. This contract marks the third award from the ONR to SPI since 2005, bringing the total level of ONR funding to $5 million. (PR Newswire)
Medicinal Plant, St John's Wort, May Reduce Neuronal Degeneration Caused By Parkinson's Disease May 14, 2009
The evaluation of antioxidant enzymes levels, superoxide dismutases, catalase, and glutathione peroxidase, conclude that administration both St John's wort extracts can prevent the increase of the three enzymes, reducing them significantly. St John's wort reduces the exacerbated production of Reactive oxygen species produced in the presence of Rotenone, as well as the damage that the free radicals cause dopaminergic neurons in the substantia nigra, avoiding the action of apoptosis. (Science Daily)
Antioxidant Supplements in Cancer T... May 3, 2009
glutathione peroxidase. superoxide dismutase. (Suite101.com)
Melatonin May Be Served As Potential Anti-fibrotic Drug Apr 8, 2009
Hepatic oxidative stress markers were evaluated by changes in the amount of lipid peroxides, measured as malondialdehyde (MDA) and glutathione peroxidase (GPx) in liver homogenates. Serum hyaluronic acid (HA), laminin (LN), and procollagen 3 N-terminal peptide (P3NP) were determined as serum markers of hepatic fibrogenesis. (Science Daily)
Modular evolution of glutathione peroxidase genes in association with different biochemical properties of their encoded proteins in invertebrate animals Apr 6, 2009
Phospholipid hydroperoxide glutathione peroxidases (PHGPx), the most abundant isoforms of GPx families, interfere directly with hydroperoxidation of lipids. Biochemical properties of these proteins vary along with their donor organisms, which has complicated the phylogenetic classification of diverse PHGPx-like proteins. (BioMed Central)
Risk of Thyroid Disease in Relative... Mar 8, 2009
TPO (thyroid peroxidase) antibody levels. Subjects were also tested for the presence and levels of Yersinia enterocolitica antibodies ( which show past gastrointestinal infection with this bacteria). (Suite101.com)
