The effect of psychological stress on iron absorption in rats Nov 13, 2009
In present study, we used communication box to create psychological stress model and investigated the iron apparent absorption, iron accumulation in the apical poles of villous enterocytes and protein expressions of ferroportin 1 (FPN1), ferritin, divalent metal transporter 1 (DMT1) ... The expression of intestinal FPN1 in 3 d and 7 d PS groups was lower than that of control, while the change of intestinal ferritin was opposite. (BioMed Central)
Figuring Out Ferroportin Nov 5, 2009
When evaluating a patient with anemia in whom inflammation is present, the physician typically observes the mean corpuscular volume and then requests biochemical analyses to determine the serum iron and ferritin levels, total iron-binding capacity, and transferrin saturation (calculated as serum iron level divided by the total iron-binding capacity, expressed as a percentage). If the transferrin saturation is less than 10% and the ferritin level is less than 30 ng per milliliter, iron deficiency... (New England Journal of Medicine)
Parkinson’s Disease: Iron Accumulation To The Point Of Demise Sep 7, 2009
They have managed to make a first-time decisive observation, namely to provide evidence of ferritin in the neuromelanin granules in the affected brain cells. Ferritin is an iron depot protein that had only been proven in the supporting cells of the brain to date, but not in neurons ... For the first time, they were now able to supply evidence of ferritin in the neuromelanin granules using a combination of diverse techniques (one-dimensional SDS gel electrophoresis, targeted mass spectrometry,... (Science Daily)
Genetically Modified Rice Aug 30, 2009
They manipulated the gene expression of two genes in the rice allowing the rice to accumulate more iron in the kernel, thus increasing the iron content six-fold (J. Wirth et al. Rice endosperm iron biofortification by targeted and synergistic action of nico-tianamine synthase and ferritin. Plant Biotechnology Journal Vol 7 631 -644 ). (Suite101.com)
Combating Iron Deficiency: Rice With Six Times More Iron Than Polished Rice Kernels Developed Jul 23, 2009
The rice plants express the two genes to produce the enzyme nicotianamin syn-thase, which mobilizes iron, and the protein ferritin, which stores iron ... Ferritin acts as a storage depot for iron in both plants and humans ... The researchers controlled the genes introduced in such a way that nicotianamin synthase is expressed throughout the rice plant, but ferritin only in the rice kernel. (Science Daily)
Can your bikini line predict fertility troubles? Jun 29, 2009
Your next step: Have your bloods ferritin levels tested. You may need to eat more iron-rich foods such as salmon and spinach, but dont take an iron supplement without your docs say-so. (MSNBC -- Health)
Centocor Ortho Biotech Data to be Presented at American Society of Clinical Oncology (ASCO) Annual Meeting May 29, 2009
Prior to and regularly during PROCRIT therapy monitor iron status; transferrin saturation should be greater than or equal to 20% and ferritin should be greater than or equal to 100 ng/mL. During therapy absolute or functional iron deficiency may develop and all patients will eventually require supplemental iron to adequately support erythropoiesis stimulated by PROCRIT.. Treatment of patients with grossly elevated serum erythropoietin levels (e. (PR Newswire)
Iron deficit can cause restless legs May 15, 2009
If you start iron pills due to ferritin levels below 50, check levels every three months to prevent iron overload and stop pills at a level of 50 or iron saturations above 50 percent. Eighty percent of those with RLS also have periodic leg movements of sleep, or PLMS. However, PLMS also may be caused by other things besides RLS, such as sleep apnea and various antidepressant and anti-psychotic drugs. (Honolulu Advertiser)
Hospital, officials ask judge today to dismiss neurosurgeons' lawsuit Apr 19, 2009
Disgusted Wyomingite wrote on Apr 17, 2009 6:05 PM:" To No Steve: Right on!!! I went to Sage Medical after our regular doctorretired. I had a blood test for Ferritin andCholestral , despite having a bloodtest from Blue Envelope . The bill wasover $400.00. I hate to see what it wouldbe if I had to have X-Rays as well.Even with "health insurance" I wouldhate to have anything "major happen"to me: pneumonia, heart attack, stroke,etc. Despite having a "college degree",I was not good enough to work... (Casper Star-Tribune, WY)
Supplements for Restless Legs Syndr... Apr 14, 2009
Iron deficiency anemia has been implicated as a possible cause of RLS. One should have their hemoglobin and preferably ferritin levels checked before considering iron supplementation, as excess iron is harmful. In studies many of those with low or low normal ferritin levels have benefited from iron supplements. (Suite101.com)
New Model For Drug Discovery With Fluorescent Anesthetic Demonstrated Apr 9, 2009
The authors identified 1-AMA in a screen for compounds that bind to a cavity in horse spleen apoferritin, HSAF, that Eckenhoff and co-workers have shown to bind clinical anesthetics. Researchers noticed a resemblance in the crystal structure of the apoferritin protein to that of the transmembrane region of the superfamily of ligand-gated channels that includes the GABA receptor ... Because 1-AMA competes with other anesthetics to bind to apoferritin, researchers surmised that the protein likely... (Science Daily)
Blood protein may hold key to stopping tumor growth in cancer patients Apr 1, 2009
Researchers found that a protein called ferritin binds to and cripples the ability of another blood protein, called HKa, to shut down blood vessel growth ... The finding led researchers to the hypothesis that if they can somehow prevent the binding of ferritin and HKa, it will allow HKa to prevent new blood vessel growth and therefore block the growth of tumors ... It is therefore possible that by increasing the binding of ferritin to HKa, one could increase the rate at which a serious wound... (EurekAlert!)
Iron is involved in prion disease-associated neuronal demise Mar 14, 2009
The group concludes that ferritin, a major iron storage protein, co-aggregates with PrP-scrapie in diseased brains and sequesters bound iron in the complex, creating a state of apparent iron deficiency. The brain cells respond to this condition by increasing their level of iron uptake, thus creating a vicious cycle of increased iron uptake in the presence of increased iron. (EurekAlert!)
YOU Docs: Weighing in on successful diets Mar 3, 2009
I just had a blood test and was told that my ferritin is high. What is ferritin, and what does having too much mean ... Think of ferritin as overdraft protection for your body's iron savings account. (Athens Banner-Herald)
Iron Overload: An Important Co-factor In The Development Of Liver Disease In Alcoholics Feb 25, 2009
5, 2007) A small protein or heptapeptide could be used to accelerate the removal of iron from ferritin, according to new research. The results of this study may help scientists develop new medications that. (Science Daily)
