Cripto-1 overexpression is involved in the tumorigenesis of nasopharyngeal carcinoma Sep 6, 2009
After the inhibition of the endogenous Cripto-1, the growth, cell cycle and invasion of cells were detected by MTT, FACS and Boyden chamber assay respectively ... Inhibition of endogenous Cripto-1 by lentivirus-mediated RNAi silencing technique suppressed NPC cell growth and invasion in vitro. (BioMed Central)
Transplanted Human Stem Cells Prolong Survival In Mouse Model Of Rare Brain Disease Sep 5, 2009
"Early intervention with neural stem cell transplants into the brains of INCL patients may supply a continuous and long-lasting source of the missing PPT1 and provide some therapeutic benefit through protection of endogenous neurons," concludes Dr. Uchida. "These data support our rationale for continued development in humans and the potential for a medical breakthrough in this deadly disease." Notably, StemCells, Inc., recently reported positive results from the first Phase 1 clinical trials... (Science Daily)
New Information About How Fat Increases Blood Pressure Could Help Identify Those At Risk Sep 4, 2009
Medical College of Georgia researchers have found that deleting or mutating the gene PTP1B puts mice at risk for hypertension by interfering with an endogenous mechanism that should help prevent it. The findings are published in the Sept. 1 issue of the American Heart Association journal Circulation. (Science Daily)
Anadys Pharmaceuticals to Present at Two Upcoming Investor Conferences Sep 4, 2009
The Company is developing ANA598, a non-nucleoside polymerase inhibitor for the treatment of hepatitis C. The Company has also investigated the potential of ANA773, an oral, small-molecule inducer of endogenous interferons that acts via the Toll-like receptor 7, or TLR7, pathway in hepatitis C.. Safe Harbor Statement. (PR Newswire)
A New Molecule To Combat Diabetes And Obesity Sep 3, 2009
Earlier work from the same group showed that bile acids (endogenous molecules involved in digestion), via the activation of TGR5 in muscle and brown adipose tissue, are able to boost energy expenditure and to prevent or reverse diet-induced obesity in mice. In the present study, the group of Dr Kristina Schoonjans and Prof. (Science Daily)
It's Not All In Your Head: Descending Neural Mechanisms Of Placebo-induced Pain Control Aug 30, 2009
Endogenous opioids, which are naturally produced by the brain in small amounts and play a key role in the relief of pain and anxiety, have been implicated in placebo analgesia. Brain imaging studies have shown that placebo analgesia stimulates release of endogenous opioids from higher brain regions associated with pain modulation and is associated with a decrease in signals from pain-sensitive areas ... Most importantly, they also observed that, under placebo, cortical areas interacted with... (Science Daily)
Membrane tether keeps Golgi intact Aug 28, 2009
Mutants comprising the full-length protein but lacking one of the terminal motifs also associated with the cis-Golgi with distribution patterns similar to those of the corresponding terminal end whereas a mutant consisting in fused N- and C-terminal ends exhibits identical localisation as the endogenous protein. Conclusion. (BioMed Central)
Runners high can turn into a real addiction Aug 27, 2009
"These findings, in conjunction with results of studies demonstrating that intake of drugs of abuse and running activates the endogenous opioid and dopamine reward systems, suggest that it might be possible to substitute drug-taking behavior with naturally rewarding behavior," she writes. She also wants to do further research on understanding the neurophysiology of extreme eating and exercise disorders. (MSNBC -- Health)
Blossoms Of Maturity: Newly Discovered Signaling Pathway Ensures That Plants Remember To Flower Aug 26, 2009
Scientists at the Max Planck Institute for Developmental Biology have found the answer to this question: An endogenous mechanism allows them to flower in the absence of external influences such as long days ... miR156-regulated SPL transcription factors define an endogenous flowering pathway in Arabidopsis thaliana. (Science Daily)
Fourth Finger May Show If You Have What It Takes Aug 25, 2009
There are the flippant ones: Women who long for high-test jobs might do better to go herbal and hunt for supplements that allege to increase endogenous testosterone. They might start popping Estratest pills, a hormone therapy that includes testosterone, than making a donation in support of the Democrat-backed , union-sponsored legislation that the AFL-CIO promotes with the promise that it will boost pay for women. (Bloomberg -- Columnists)
NovaBay Pharmaceuticals to Present New Data on Lead Anti-Infective Compound at the 2009 ICAAC Annual Meeting Aug 22, 2009
Miscellaneous Abstract Number: E-1468 Location: Hall B Poster Title: Antimicrobial activity of endogenous and stabilized derivatives of N-chlorotaurines against representative microorganisms in the presence of human plasma, serum and albumin Date/Time: Monday September 14, from 11:15 am to 1:15 pm (Pacific Time) Session: 167-New Topical Antibacterial Agents Including Agents against C. difficile Abstract Number: F1-1526 Location: Hall B. "These findings support the compelling therapeutic profile... (PR Newswire)
Integrity deficit has its price Aug 20, 2009
Within commodities markets, with free supply of money, the cost of which declines in proportion to its abundance, both supply and demand are no longer merely endogenous (within the system) components of the market economy. Both supply and demand are highly vulnerable to exogenous (external) purposeful manipulation by five major groups of market participants. (Asia Times Online)
Chicken CR1 elements not repressed by Dicer Aug 20, 2009
Here, we describe how the loss of Dicer in chicken cells does not reactivate endogenous chicken CR1 retrotransposons with impaired RNAi machinery, suggesting that the control of chicken CR1 is independent of Dicer-induced RNAi silencing. In contrast, upon introduction of a functionally active human L1 retrotransposable element that contains an active 5' UTR promoter, the Dicer-deficient chicken cells show a strong increase in the accumulation of human L1 transcripts and retrotransposition... (BioMed Central)
Phospholipid and connexin association Aug 17, 2009
Endogenous phospholipids most tightly associated with purified connexin26 or connexin32 hemichannels or with junctional plaques in cell membranes, those likely to have structural and/or modulatory effects, were identified by tandem electrospray ionization-mass spectrometry using class-specific interpretative methods ... The results indicate that specific endogenous phospholipids are uniquely associated with either connexin26 or connexin32 channels, and some phospholipids are associated with both... (BioMed Central)
Discovery Brings Hope To Treatment Of Lymphatic Diseases Aug 15, 2009
This paper by Dr. Ambati and his coworkers represents another in a line of highly novel and important findings from their laboratory," said Patricia A. D Amore, Professor of Ophthalmology and Pathology, Harvard Medical School and Senior Scientist at the Schepens Eye Research Institute. "The report of the first endogenous inhibitor of lymphangiogenesis is an exciting development and holds great therapeutic promise for a number of pathologies in which lymphatic growth is a serious complication ...... (Science Daily)
The bill will fall duefor crisis failures Aug 13, 2009
Economic history has established that the credit system is inherently unstable and goes through endogenous and periodic crises. Banks emit liabilities, or money, and they jointly multiply this money through loans, commonly referred to as the creation of money by the banking system. (Asia Times Online)
What Do Babies Think About All Day? Aug 11, 2009
Adult attention is willful and endogenous. Although it can be captured by external eventswe will turn if we hear a loud noisewe also have control over what to think about and what to attend to. (Slate)
A Biochemical Way to Reduce Drug Side Effects? Aug 11, 2009
The pharmaceutical doppelgangers of such endogenous substances latch onto cell-surface receptor molecules exactly where the native substances bind ... And because the body has evolved to use the same chemicals for multiple purposes, one endogenous molecule often binds to a range of receptor subtypes, each responsible for different tasks so drugs intended to replicate the action of, say, a given neurotransmitter on just one subtype may end up affecting many subtypes, leading to side effects. (Scientific American)
Acute effect of electroacupuncture at the Zusanli acupoints on decreasing insulin resistance as shown by lowering plasma free fatty acid levels in steroid-background male rats Aug 2, 2009
In addition, plasma glucose and endogenous insulin levels were assayed to calculate the homeostasis model assessment (HOMA) index. Intravenous glucose tolerance test (IVGTT) was carried out to compare glucose tolerance. (BioMed Central)
Food Additive May One Day Help Control Blood Lipids And Reduce Disease Risk Aug 2, 2009
Chakravarthy MV, Lodhi IJ, Malapaka RV, Xu HE, Turk J, Semenkovich CF. Identification of a physiologically relevant endogenous ligand for PPAR%u03B1 in liver. Cell, 2009 DOI. (Science Daily)
Great Wall of confusion Aug 1, 2009
Tim Bond, of Barclays Capital, suggests they are unwilling to believe that the region is capable of endogenous growth. But the sceptics have an important case. (FT.com -- Markets)
Breakthrough In Transgenic Animal Production Enables Development Of New Human Disease Models Jul 25, 2009
"Inactivation of endogenous rat antibody expression is essential for human antibody expression in genetically engineered animals. To solve this problem, we used ZFN technology in an application that has the potential to revolutionize genetic engineering of animals.". "We have invested our time and resources to develop the CompoZr platform because we see enormous potential in a technology that can precisely manipulate the genome of living organisms," said Dr. David Smoller, President of... (Science Daily)
For the Heavy, Economic Woes Can Mean Weight Gain Jul 24, 2009
And eating causes the brain to release feel-good chemicals called endogenous opiates, he added, so certain people may rely on eating as a way to soothe themselves and release stress. "It appears to be a kind of comfort-eating thing as well as a cortisol thing.". (MEDLINEplus)
Potential New Drug Target For Diabetes And Alzheimer's Disease Jul 24, 2009
Furthermore, "the remarkable activity of this novel peptide proposes a new role for an emerging class of endogenous molecules derived from the mitochondria that have previously been overlooked and can potentially represent a different paradigm for drug development for a variety of diseases," says Dr. Pinchas Cohen, co-senior author, professor and chief of endocrinology at the Mattel Children's Hospital UCLA and co-director of the UCSD/UCLA Diabetes/Endocrinology Research Center at the David... (Science Daily)
Buttonwood: Cold comfort Jul 24, 2009
The endogenous factors (those originating within the system) seem so much more important. It was not a disease or a war or an election that plunged the economy into crisis, but a combination of bad lending decisions and the excessive leverage of banks at the heart of the financial system. (The Economist)
New Zealand researchers to implant pig cells in diabetics Jul 23, 2009
Elliott said Thursday that the risk of a pig endogenous retrovirus the porcine virus thought to be most contagious for humans infecting humans is largely "theoretical.". "There is no evidence of a risk" of retrovirus infection, he said. (Honolulu Advertiser)
Cystic Fibrosis - Liposomal Tobramycin Receives Second Orphan Drug Designation Within Weeks Jul 16, 2009
Axentis Pharma's Fluidosomes(TM) technology uses biocompatible lipids endogenous to the lung that are formulated into small liposomes. This nanocapsule platform offers wide-ranging potential for unmet medical needs, including chronic respiratory infections of the lung. (PR Newswire)
Active Ingredient In Cannabis Eliminates Morphine Dependence In Rats Jul 16, 2009
In addition, there is a correlation between such behavioral disturbances linked to dependence, and hypoactivity of the enkephalinergic system, the endogenous opioid system ... In the striatum, a region of the brain involved in drug dependence, the production of endogenous enkephalins was restored under THC, whereas it diminished in rats stressed from birth which had not received THC. ... The enkephalinergic system produces endogenous enkephalins, which are neurotransmitters that bind to the same... (Science Daily)
Tom Ricks: Obama's Faith-Based Pullout Jun 30, 2009
Tom, My opinion on this subject, after more than three years studying US military actions in Iraq and their interactions with the endogenous dynamics of conflicts since 2003 (my PhD dissertation), is that one has to make the distinction between military successes (retaking control of many parts of the country from AQI) and political semi-failures (this is more or less the same as your distinction between Tactical successes and Strategic failures) ... The US intervention and the toppling of... (Slate)
Car wash raises money for activist's funeral Jun 26, 2009
Place an obit: (559) 441-6228. Web Search powered by YAHOO. (Fresno Bee)
Tracking Down The Causes Of Multiple Sclerosis Jun 25, 2009
Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOGreactive transgenic T cells recruit endogenous MOG-specific B cells. Journal of Experimental Medicine, June 1st, 2009. (Science Daily)
The Promise of Low Dose Naltrexone ... Jun 23, 2009
This stimulates the body to produce more of its own endogenous opioids, resulting in powerful immunomodulatory and neuroprotective actions ... Unfortunately it also blocks the endogenous opioid peptides binding from these receptors, resulting in troublesome side effects. (Suite101.com)
Who’s to Blame for Waxman-Markey?, ctd. Jun 21, 2009
You can cite 60+ in the Senate but of course this is endogenous to what the Democrats themselves think public opinion will bear. There is a reason why the Democratic establishment does not, as Matt Yglesias so often recommends, abolish the 60+ requirement. (The American Conservative)
Small Molecules Mimic Natural Gene Regulators Jun 5, 2009
Amphipathic Small Molecules Mimic the Binding Mode and Function of Endogenous Transcription Factors. ACS Chemical Biology, 2009; DOI. (Science Daily)
C3 Polymorphisms and Outcomes of Renal Allografts Jun 4, 2009
Moreover, the C3 SS genotype can be either a protective factor1 or an exacerbating factor in the progression of endogenous kidney disease, and it varies according to the disorder. For example, the SS genotype is associated with accelerated progression of membranous nephropathy3 and. (New England Journal of Medicine)
The Vulnerable Cancer Cell: New Studies Reveal Broad, Hidden Network That Lets Tumors Thrive May 30, 2009
While the natural function of RNAi is to prevent viruses from replicating inside cells and to control endogenous gene expression, scientists discovered they could exploit the process to squelch individual gene products. To do so, they introduce a short segment of RNA that looks like one of the cell's normal genes. (Science Daily)
Heart Muscle Protein Can Replace Its Missing Skeletal Muscle Counterpart To Give Mice With Myopathy Long And Active Life May 28, 2009
Besides pondering that, Nowak and colleagues are also working out how to boost endogenous ACTC as a possible therapy for ACTA1-lacking patients. Journal reference: Nowak, K.J., et al. 2009. (Science Daily)
LXR Proteins: New Target In The War On Tuberculosis? May 17, 2009
27, 2006) In a new study, scientists at the Scripps Research Institute have described for the first time a glucose-activated sensor that acts as a switch to decrease production of endogenous glucose in the. (May 16, 2005) Researchers at the University of Pennsylvania School of Medicine have discovered that a molecule found in liver cells is an important link in explaining the relationship among diet, lipid levels in. (Science Daily)
TCF/beta-catenin plays an important role in HCCR-1 oncogene expression May 13, 2009
In addition, endogenous HCCR-1 expression was also increased by treatment with LiCl in HEK/293 and K562 cells. Finally, we also observed that the transcription factor, TCF, and its cofactor, beta-catenin, bound to the Tcf1 site. (BioMed Central)
Recent developments at Burnham Institute for Medical Research, May 2009 May 13, 2009
Post-doctoral fellow Benjamin Faustin, in Dr. John Reed's laboratory, in collaboration with Dr. Arnold Satterthwait and colleagues, studied how endogenous inhibitors of NLRs function in hopes of developing strategies for mimicking their actions ... The findings have resulted in several new drug screening assays, which the team hopes to put to use to identify chemicals that mimic the endogenous inhibitors of NLRs and thus suppress inflammation. (EurekAlert!)
Texas A&M meat science expert explains health advantages of high quality beef (2) May 10, 2009
Oleic acid comes from both endogenous synthesis and dietary fats, and the level can be manipulated. The scientific literature suggests that, you can't eat too much oleic acid, he said, adding that corn feeding increases it in beef. (Sioux Falls Tri-State Neighbor, SD)
Calorie restriction causes temporal changes in liver metabolism May 5, 2009
Researchers found that short-term CR caused a rapid decrease in IHTG content, an increase in hepatic insulin sensitivity and a decrease in endogenous glucose production rate, whereas longer-term CR and a moderate 7 percent weight loss improved skeletal muscle insulin sensitivity in conjunction with an increase in cellular insulin signaling. The effect of moderate CR in obese patients with either a low-fat or low-carbohydrate diet on metabolic function is a continuum, with differential effects on... (EurekAlert!)
Endometriosis Apr 30, 2009
We recently found that what was believed to be aromatase protein was mainly endogenous biotin labeling or iron deposits. 3 Using three different protocols. (New England Journal of Medicine)
Phillies reliever Romero sues supplement maker Apr 28, 2009
At various Web sites on the Internet, 6-OXO Extreme is touted as a product for "maximum testosterone production FOR HARDCORE USERS ONLY;" a "testosterone booster" that will "raise endogenous testosterone production;" and a supplement that "stimulates levels well into the supraphysiological range." 6-OXO also is marketed as an "aromatase inhibitor," which means it works to enhance natural production of testosterone. Aromatase inhibitors are banned by the World Anti-Doping Agency, but not in... (ESPN -- Baseball)
Biomarker Associated With Poor Outcome In Aggressive Childhood Cancer Apr 15, 2009
"Expression levels of ZNF423 could significantly affect responses to both endogenous and pharmacological concentrations of RA in cancer patients, which may in turn influence the outcome of neuroblastoma," offers Dr. Bernards. "Therefore, ZNF423 may be a useful biomarker for predicting responses to RA-based therapies, which are increasingly being used to treat neuroblastoma.". (Science Daily)
Supplements for Restless Legs Syndr... Apr 14, 2009
Not only does it increase brain levels of dopamine, but also those of endogenous opioids such as beta endorphin ... Walters AS, Ondo WG, Zhu W, Le W. Does the endogenous opiate system play a role in the Restless Legs Syndrome. (Suite101.com)
Hildreth: Why are we seeing so many symptoms of imbalance? Apr 11, 2009
It is the mixture of multiple exogenous estrogenic substances and their interactions with endogenous hormones or our naturally produced internal hormones that are most concerning. As grandparents, it is this type of information that we can pass on to our kids and our grandchildren that may save a lot of heartaches in the future. (Green Valley News & Sun, AZ)
Cancer Stem Cells Generated By Cancer Outgrowth Apr 6, 2009
"To our knowledge, this is the first example that silenced endogenous embryonic stem cell genes can be spontaneously reactivated in differentiated cells," says Dr. Dean. "We propose that the loss of cell contact inhibition when the RB1 pathway is inhibited leads to outgrowth into sphere-like structures, and these conditions in the advancing cancer trigger reprogramming of differentiated cells to cells with properties of cancer stem cells.". (Science Daily)
New Strategy Improves Stem Cell Recruitment, Heart Function And Survival After Heart Injury Apr 6, 2009
Because SDF-1 is inactivated by CD26/dipeptidylpeptidase IV (DPP-IV), endogenous stem cell localization to the heart is not optimal. The researchers used genetic or pharmacologic inhibitors of CD26/DPP-IV to slow degradation of SDF-1 in mice with surgically induced MI. They also treated the mice with granulocyte colony stimulating factor (GCSF), a commonly used drug that mobilizes multiple stem cell populations from the bone marrow to the blood. (Science Daily)
Ghanas Lactogen Banks: Apr 5, 2009
Notwithstanding the pressures of the surrounding environment (exogenous factors so to speak), a good chunk of the nasty spreads we have been discussing stem from factors internal to the banking system itself (so-called endogenous factors). We will argue that the high lending rates owe in part to lower than expected competition within the sector. (Ghana Web, Ghana)
Resolvins have the potential to resolve periodontal inflammation and restore tissue health Apr 5, 2009
The Resolvins are natural endogenous regulators of the immune system against inflammation. Compounds derived from EPA are designated Resolvins of the E series (RvE1), and those biosynthesized from DHA are denoted Resolvins of the D series (RvD). (EurekAlert!)
Drug Suppresses The Compulsion To Steal, Study Shows Apr 4, 2009
Naltrexone is a drug that blocks the effects of endogenous opiates that may be released during stealing; in other words, it blocks the part of the brain that feels pleasure with certain addictive behaviors. They found that after eight weeks of treatment, naltrexone was able to reduce the urges to steal and stealing behavior in people with kleptomania. (Science Daily)
Anti-Addiction Drug Quells Kleptomaniac Impulses Apr 3, 2009
Naltrexone blocks the effects of substances called endogenous opiates that the researchers suspect are released during stealing and which trigger the sense of pleasure in the brain. After eight weeks of treatment, the drug reduced the urges to steal and stealing behavior, the scientists report today in the journal Biological Psychiatry. (Fox News)
Japan in search of a grand strategy Mar 27, 2009
What this means is that development must aim to advance the freedom to choose and consolidate its infrastructure like hygiene, nutrition, medical care, education and gender equality on the basis of solid endogenous economic foundations ... As a matter of urgency, Japan should help the bottom billion people in the world with its self-sustainable course of endogenous human development. (Asia Times Online)
Paradigm Shift In Immune Response Regulation Mar 26, 2009
(June 17, 2008) A novel small molecule inhibitor reduced both endogenous and drug-induced resistance to chemotherapy in a mouse model of melanoma. The NF- B pathway is often active in human cancers and promotes. (Science Daily)
Naltrexone Can Help Heavy Social Drinkers Quit Smoking Mar 26, 2009
"Both nicotine and alcohol may stimulate brain reward pathways connected to endogenous opioids meaning the 'endorphins' which are feel-good brain chemicals as well as dopamine," she said. "An opioid blocker like naltrexone therefore may benefit persons who use both substances concurrently." She and her research team are trying to replicate these findings with a larger group of participants. (Science Daily)
Herpes: Scientists find cellular process that fights virus Mar 24, 2009
The paper, "Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection," published in Nature Immunology, was produced by Luc English, Magali Chemali, Johanne Duron, Christiane Rondeau, Annie Laplante, Diane Gingras, Roger Lippe and Michel Desjardins of the Universit de Montral in collaboration with Diane Alexander and David Leib of Washington University and Christopher Norbury of Pennsylvania State University. On the Web. (EurekAlert!)
Cold Sore Cure? New Way To Fight Herpes Virus Mar 24, 2009
Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection. Nature Immunology, 2009; DOI. (Science Daily)
Low To Moderate, Not Heavy, Drinking Releases 'Feel-good' Endorphins In The Brain Mar 21, 2009
One possibility is that alcohol may increase or decrease the release and the synthesis of endogenous opioid peptides endorphins, enkephalins and dynorphins in distinct brain regions important for drug addiction ... "Like morphine, endogenous opioid peptides can induce analgesia and a mild euphoric effect, reduce anxiety, and may lead to a general feeling of well being. Therefore, increased release of endogenous opioid peptides in response to drinking could be partially responsible for the mild... (Science Daily)
Anadys Pharmaceuticals to Present at the Cowen and Company Healthcare Conference Mar 13, 2009
For the treatment of chronic hepatitis C, the Company is developing two potentially complementary agents, ANA598, a non-nucleoside polymerase inhibitor and ANA773, an oral inducer of endogenous interferons that acts via the TLR7 pathway. The Company is also developing ANA773 for the treatment of cancer. (PR Newswire)
Causes of Itchy Palms and Soles Mar 7, 2009
Endogenous Causes for Itchy Palms and Soles. Systemic causes for itchy palms and soles. (Suite101.com)
Pioneering Diamyd(r) Study to Prevent Childhood Diabetes Approved Mar 4, 2009
Ina more recent Phase II study, Diamyd(r) treatment of children and adolescents with type 1 diabetes and a certain remaining endogenous insulin production lead to a clearly improved disease process. The results from this study were published in the New England Journal of Medicine in October 2008. (Primezone Releases)
How to Get Rid of Hand Eczema Mar 2, 2009
There are many different causes, both exogenous and endogenous, for hand eczema ... Endogenous Hand Eczema. (Suite101.com)
Scientists at CSHL discover mobile small RNAs that set up leaf patterning in plants Mar 1, 2009
These native, or endogenous, small RNAs are called trans-acting small interfering RNAs (ta-siRNAs). Like microRNAs and endogenous siRNAs present in other organisms, they regulate gene activity via a mechanism called RNA interference. (EurekAlert!)
Hormones May Help Shield Women from Parkinson's Feb 27, 2009
"These findings suggest that longer duration of exposure to the body's own [endogenous] hormones may help protect the brain cells that are affected by Parkinson's disease," study author Dr. Rachel Saunders-Pullman, of Albert Einstein College of Medicine in New York City, said in a news release from the American Academy of Neurology. Researchers have long believed a women's hormones may affect her chances of developing the disease. (MEDLINEplus)
