Insulin Resistance Stops Superoxide... Nov 21, 2009
Superoxide Dismutase Eliminates Superoxide. Superoxide in small amounts can be converted to hydrogen peroxide by the enzyme superoxide dismutase ... Mouse lines with more or less mitochondrial superoxide dismutase respond differently than normal mice to conditions that would otherwise affect superoxide levels. (Suite101.com)
Tiny particles can deliver antioxidant enzyme to injured heart cells Nov 16, 2009
The enzyme in the particles, called superoxide dismutase (SOD), soaks up toxic free radicals produced when cells are deprived of blood during a heart attack. Previously scientists have tried injecting SOD by itself into injured animals, but it doesn't seem to last long enough in the body to have any beneficial effects. (EurekAlert!)
Hydrogen Peroxide May Tell Time For Cells Nov 4, 2009
Tower and his team had noticed that overexpression of the enzyme, known as superoxide dismutase (SOD), boosted the activity level of fruit flies and even increased the life span of certain genetically engineered strains. Tower suspected that hydrogen peroxide was the key ingredient in SOD's action. (Science Daily)
Dysfunctional Protein Dynamics Behind Neurological Disease? Nov 3, 2009
It turns out that the protein superoxide dismutase interchanges between its normal structure and a misfolded form ... Transient structural distortion of metal-free Cu/Zn superoxide dismutase triggers aberrant oligomerization. (Science Daily)
Compound Shows Potential For Slowing Progression Of Lou Gehrig's Disease Oct 21, 2009
The research involved mice with a mutation in a gene known as superoxide dismutase 1 (SOD1), which plays an important role keeping cells safe from damaging molecules known as free radicals. While the cause of most cases of ALS is unknown, scientists do know that SOD1 plays a role in approximately 3 or 4 percent of cases providing an opportunity to study the disease's initial steps, which occur long before key nerve cells appear sick or die. (Science Daily)
Characterization of the oxidative stress stimulon and PerR regulon of Campylobacter jejuni Oct 19, 2009
Mutagenic and phenotypic studies of the superoxide dismutase SodB, the alkyl-hydroxyperoxidase AhpC, and the catalase KatA, revealed a role for these proteins in oxidative stress defense and chick gut colonization. Conclusion. (BioMed Central)
New research provides new insight into age-related muscle decline Sep 23, 2009
They started with fruit flies that lack mitochondrial superoxide dismutase enzyme (SOD), which provides the primary line of defense against ROS by capturing the superoxides and converting them to water. This lack of SOD caused the fruit flies to die within a day after hatching. (EurekAlert!)
Stressed? Eat Melon Sep 17, 2009
Melon contains an enzyme called superoxide dismutase (SOD) ... The 35 people in our study who received capsules containing superoxide dismutase showed improvement in several signs and symptoms of perceived stress and fatigue. (Newsmax)
Compound in melon 'may help reduce stress' Sep 16, 2009
The key ingredient is an enzyme called superoxide dismutase, thought to have beneficial antioxidant properties which prevent damage to the body's tissues. Volunteers given a capsule containing the enzyme reported fewer symptoms of stress and fatigue than those given a dummy capsule. (BBC News -- Health)
Antioxidant Ingredient Proven To Relieve Stress Sep 16, 2009
15, 2009) A dietary ingredient derived from a melon rich in antioxidant superoxide dismutase enzymes has been shown to relieve stress ... She said: "Several studies have shown that there is a link between psychological stress and intracellular oxidative stress. We wanted to test whether augmenting the body's ability to deal with oxidative species might help a person's ability to resist burnout. The 35 people in our study who received capsules containing superoxide dismutase showed improvement in... (Science Daily)
Delta-opioid receptors reduce oxidative injury Aug 26, 2009
We observed that, in a model of cerebral ischemia with middle cerebral artery occlusion, DOR activation increased the activity of major antioxidant enzymes, glutathione peroxidase and superoxide dismutase, and decreased malondialdehyde and nitric oxide levels in the cortex exposed to cerebral ischemia/reperfusion. In addition, DOR activation reduced caspase 3 expression, though it did not significantly affect the increase in interleukin (IL)1beta and tumor necrosis factor (TNF)alpha expression... (BioMed Central)
Selenium intake may worsen prostate cancer in some, study reports Jun 26, 2009
The variants are slightly different forms of a gene that instructs cells to make manganese superoxide dismutase (SOD2), an enzyme that protects the body against harmful oxygen compounds. The research findings suggest that "if you already have prostate cancer, it may be a bad thing to take selenium," says Philip Kantoff, MD, director of Dana-Farber's Lank Center for Genitourinary Oncology and senior author of the study that is published by the Journal of Clinical Oncology on its website now and... (EurekAlert!)
Does lung cancer get short shrift? Jun 21, 2009
He has found that doctors can counteract the toxicity of the treatment if patients swallow a substance that produces the enzyme manganese superoxide dismutase. Even if people have a hard time relinquishing their disdain for smokers, there are two other good reasons not to be dismissive toward lung cancer patients, the activists said. (Pittsburgh Post-Gazette, PA)
Finding Raises Hope for Treating ALS Jun 17, 2009
The Florida researchers examined the gene that produces superoxide dismutase 1, or SOD1, an enzyme that fights off free radicals -- molecules that damage the body's cells. People with the inherited version of ALS have been found to have one of the 146 known mutations in the SOD1 gene. (MEDLINEplus)
Today In the Kitchen: Aloe vera’s benefits May 15, 2009
It contains SOD (superoxide dismutase), an enzyme that helps protect cell membranes from free radical damage. As with all nutrients, those in natural food form are better than pills because the body can more readily absorb and utilize them. (Green Valley News & Sun, AZ)
UMMS researchers isolate first 'neuroprotective' gene in patients with amyotrophic lateral sclerosis May 12, 2009
In 1993, a team of researchers led by Dr. Brown discovered the first gene linked to familial ALS, a protein anti-oxidant known as superoxide dismutase, or SOD1. Earlier this year, Dr. Brown and his colleagues discovered a mutation in the FUS/TLS gene which is estimated to account for 5 percent of inherited ALS cases. (EurekAlert!)
Hans Selye Foundation Targets 2009 Stress Casualties: A Science-based Agenda for Coaches and Trainers Apr 30, 2009
Superoxide dismutase information and products. New Puppy. (Yahoo News -- Press Releases)
New study overturns orthodoxy on how macrophages kill bacteria Apr 28, 2009
Bacteria and animal cells contain special enzymes, called superoxide dismutases, which neutralize an important ROS, called superoxide ... To test this hypothesis, Slauch and graduate student Maureen Craig looked at the superoxide dismutases that are part of the bacterial defense against ROS. There are two such enzymes in the cytoplasm of S. typhimurium, called SodA and SodB, and another, SodC, in the periplasm, the space between the bacteria's inner and outer membranes ... These results suggest... (EurekAlert!)
Patricia Goodwin: Go with the grain Apr 3, 2009
This trace mineral helps produce a very important antioxidant enzyme called superoxide dismutase. Manganese also produces energy from protein and carbohydrates and is involved in the synthesis of fatty acids, which are important for a healthy nervous system. (Hamilton Wenham Chronicle, MA)
Changes In Gene May Stunt Lung Development In Children Apr 1, 2009
D., professor of occupational and environmental health at the University of Pittsburgh Graduate School of Public Health, and Holger Schulz, M.D., professor of medicine at the Institute of Lung Biology and Disease, German Research Center for Environmental Health, Munich, focused on a gene called superoxide dismutase 3 (SOD3), previously shown to protect the lungs from the effects of asbestos and oxidative stress ... Ganguly et al. Superoxide dismutase 3, extracellular (SOD3) variants and lung... (Science Daily)
Forget The Antioxidants? Researchers Cast Doubt On Role Of Free Radicals In Aging Feb 19, 2009
They progressively disabled five genes responsible for producing a group of proteins called superoxide dismutases (SODs), which detoxify one of the main ROS. Earlier studies seemed to show that decreased SOD production shortened an organism's lifespan, but Hekimi and Van Raamsdonk did not observe this ... Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans. (Science Daily)
