Resveratrol inhibits nonalcoholic fatty liver disease in rats. Sep 10, 2008
Levels of TNF-alpha in serum, hepatic malondialdehyde (MDA), oxidative stress (superoxide dismutase, glutathione peroxidase, catalase and nitric oxide synthase) and biochemical parameters were measured ... This was accompanied by increased superoxide dismutase, glutathione peroxidase and catalase and decreased nitric oxide synthase in the liver of resveratrol group significantly (P<0. (BioMed Central)
Biodegradable Polymers Show Promise For Improving Treatment Of Acute Inflammatory Diseases Aug 25, 2008
One treatment is the delivery of superoxide dismutase, an enzyme that detoxifies superoxide ... Scanning electron microscope image of polyketal microparticles loaded with the therapeutic enzyme superoxide dismutase, which is used to treat acute liver failure. (Science Daily)
Transcriptional responses of Arabidopsis thaliana plants to As (V) stress Aug 7, 2008
e. coding for superoxide dismutases and peroxidases) play prominent roles in response to arsenate. The microarray experiment revealed induction of chloroplast Cu/Zn superoxide dismutase (SOD) (at2g28190), Cu/Zn SOD (at1g08830), as well as an SOD copper chaperone (at1g12520). (BioMed Central)
Protein Plays Jekyll And Hyde Role In Lou Gehrig's Disease Jul 31, 2008
Scientists discovered fifteen years ago that mutations in the gene that makes the protein, superoxide dismutase, are responsible for inherited ALS, but how these mutations cause ALS remain a mystery ... Agar's research demonstrated that fALS is caused by two synergistic properties of the protein superoxide dismutase, creating toxic levels of the protein in motor neurons ... "The protein superoxide dismutase, normally a useful antioxidant, goes from Dr. Jekyll to Mr. Hyde when it clumps up," said... (Science Daily)
Scientists ID 'Jekyll-Hyde' Protein in Lou Gehrig's Disease Jul 29, 2008
Gene mutations cause superoxide dismutase to clump up in motor neurons ... About 15 years ago, scientists found that mutations in the gene that makes the protein superoxide dismutase caused familial ALS, but just how these mutations cause ALS has remained a mystery ... In this new study, researchers found that fALS is caused by two properties of superoxide dismutase that create toxic levels of the protein in motor neurons. (Health-Finder)
Should Children Take Statins Jul 13, 2008
CoQ10 exerts an antioxidant influence at the cellular level by sparing glutathione and superoxide dismutase, thus protecting cells from cancer-promoting free radicals. Clearly, the issue of cholesterol management is not as straightforward as some would like it to be. (Suite101.com)
Genetics of ALS progression Jun 1, 2008
About 20% of these familial ALS cases are the result of an inherited genetic mutation on chromosome 21, in the gene encoding for the superoxide dismutase 1 (SOD1) enzyme. SOD1 is an antioxidant that protects the body from DNA damage caused by the accumulation of free radicals within cells. (EurekAlert!)
Effect of exercise therapy on lipid profile and oxidative stress indicators in patients with type 2 diabetes May 14, 2008
The oxidative stress indicators (malondialdehyde - MDA, protein oxidation - POX, phospholipase A2 - PLA2 activity) and oxidative status [superoxide dismutase (SOD) and catalase activities] were measured. Results. (BioMed Central)
Leaky blood vessels open up nerve cells to toxic assault in Lou Gehrig's disease Apr 8, 2008
The team studied mice with a mutation in a gene for superoxide dismutase 1 (SOD-1), which in healthy people and mice plays an important role keeping cells safe from damaging molecules known as free radicals. Scientists estimate that SOD-1 mutations play a role in a small number of cases of ALS overall in people, about one-quarter of the 10 percent or so of cases that are inherited. (EurekAlert!)
New Gene Responsible For Lou Gehrig's Disease Identified Apr 1, 2008
In 1993, Dr. Rouleau and his team also helped identify "superoxide dismutase" as the gene that causes the disease in 10 to 20 percent of all familial cases of ALS. This cornerstone study led to development of several mouse and rat models of ALS that closely resemble the motor neuron disorder observed in ALS patients. These models have been very useful to study molecular and cellular mechanisms of disease and to test treatments for ALS.. (Science Daily)
ALS Aggregates Are Composed Of Only One Protein Apr 1, 2008
31, 2008) Researchers have provided a big new clue to help combat amyotrophic lateral sclerosis (ALS), deciphering that the dense protein aggregates that contribute to the nerve decay of ALS are composed of just one protein: superoxide dismutase (SOD1). See also. (Science Daily)
Story ideas from the Journal of Biological Chemistry Mar 22, 2008
Researchers have provided a big new clue to help combat amyotrophic lateral sclerosis (ALS), deciphering that the dense protein aggregates that contribute to the nerve decay of ALS are composed of just one protein: superoxide dismutase (SOD1). While the aggregation of mutated SOD1, a protein that normally protects cells from free radical damage, is a tell-tale sign of familial ALS, the exact composition of these aggregates has been unclear. (EurekAlert!)
Potential New Weapon against Lou Gehrig's Disease Nov 30, 2007
In the 10 percent of inherited cases, a common mutation occurs in the gene superoxide dismutase 1 (SOD1), which is the gene that the Wake Forest team altered in its mouse model. Fifty days after the mice were born, one group was injected three times a week with Hsp70 and another received Riluzole, approved by the Food and Drug Administration to combat ALS.. (Scientific American)
Yoga can help heart failure patients Nov 7, 2007
The study found significant differences in levels of biological markers in the blood interleukin-6, C-reactive protein and extra-cellular superoxide dismutase between patients who completed the yoga therapy and those who received standard medical therapy. Patients on yoga therapy completed the regimen without complications. (MSNBC -- Health)
Amorfix Life Sciences develops two vaccines that extend life in Amyotrophic Lateral Sclerosis (ALS) animal model Oct 9, 2007
In March, Amorfix established a passive immunization approach in the same mouse model of ALS by injecting monoclonal antibodies that target the misfolded superoxide dismutase 1 (SOD1) protein. The paper entitled "Active and Passive Immunization of SOD1 Disease Specific Epitopes in a Mouse Model of Amyotrophic Lateral Sclerosis" will be presented by Dr. Neil Cashman, the Chief Scientific Officer of Amorfix. (Canada Newswire)
Nanotechnology Identifies Peptide 'Fingerprint' In Both Forms Of ALS Sep 17, 2007
The UB researchers identified that this unique, cross-linked species contains superoxide dismutase, a protein that had been previously linked to only the familial form of ALS.. "These results say that the mechanism in ALS involving superoxide dismutase is even more general," said Wood. (Science Daily)
Handicapping Tuberculosis May Be The Way To A Better Vaccine Aug 3, 2007
A weapon in TB's arsenal is an enzyme called superoxide dismutase A, or sodA. This enzyme helps TB cover its tracks, so the macrophage doesn't know it's infected. Jacobs and his team hypothesized that eliminating this enzyme's activity would give macrophages the opportunity to trigger apoptosis, thus prompting a more effective immune response. (Science Daily)
Amorfix acheives first milestone in therapeutic ALS partnership with Biogen Idec Jul 23, 2007
"We have successfully achieved the first of three predefined milestones for our therapeutic ALS program with Biogen Idec. The research is focused on the role of monoclonal antibodies targeted to misfolded superoxide dismutase 1 (SOD1) for the treatment of ALS," said Dr. George Adams, CEO of Amorfix Life Sciences. "Achieving this technical milestone provides additional validation of our general approach to treat all aggregated misfolded protein diseases." Amorfix has demonstrated that a targeted... (Canada Newswire)
New Clue Into How Diet And Exercise Enhance Longevity Jul 21, 2007
"It reduces the amount of insulin needed in the body to control blood glucose, and it promotes growth, survival and insulin secretion from pancreatic beta cells. In earlier work, the researchers had found that knocking out both copies of the Irs2 gene in mice reduces brain growth and produces diabetes due to pancreatic beta cell failure. However, in the new study, when the researchers knocked out only one copy of the gene, they found the mice lived 18 percent longer than normal mice. Because... (Science Daily)
Shielding The Brain From Too Much Insulin Can Prolong Life Jul 21, 2007
They were more active in old age, retained youthful metabolic cycles (burning sugar by day and fat by night) and retained protective levels of anti-oxidant enzymes such as superoxide dismutase, which protect against oxidative stress, or "biological rusting," in the brain and body. In contrast, the mice with normal insulin signaling had become more sedentary, had lost the metabolic rhythms of youth and had reduced anti-oxidant enzymes, leaving them vulnerable to cellular damage. (Science Daily)
Less Insulin In Brain Is Key To Long Life Jul 21, 2007
They were also more active than normal mice, and after eating, their brains had higher levels of a compound called superoxide dismutase, an antioxidant that protects cells from damage. "Diet, exercise and lower weight keep your peripheral tissues sensitive to insulin," White said. (Newsmax)
Molecular evolution of the reactive oxygen-generating NADPH oxidase (Nox/Duox) family of enzymes Jul 6, 2007
In contrast to ROS defense enzymes, such as superoxide dismutase and catalase that are present in prokaryotes, ROS-generating Nox/Duox orthologs only appeared later in evolution. Molecular taxonomy revealed seven distinct subfamilies of Noxes and Duoxes. (BioMed Central)
Enzyme Delivered In Smaller Package Protects Cells From Radiation Damage Jun 5, 2007
Based on previous studies showing that intravenous gene therapy delivery of the enzyme manganese superoxide dismutase (MnSOD) could protect mice from whole body irradiation, and in preparation for a potential clinical trial of systemic MnSOD in humans, the University of Pittsburgh and Stanford researchers, led by Joel S. Greenberger, M.D., professor and chair of the department of radiation oncology, University of Pittsburgh School of Medicine, delivered the human MnSOD enzyme into mouse... (Science Daily)
Levels of oxidative stress biomarkers in seminal plasma and their relationship with seminal parameters Jun 1, 2007
The aim of the present study was to assess seminal plasma levels of total antioxidant capacity (TAC), free 8-Isoprostane and activities of catalase and superoxide dismutase (SOD) in men with asthenozoospermia, asthenoteratozoospermia and oligoasthenoteratozoospermia compared with normozoospermic males. Methods. (BioMed Central)
New Insight Into Cause Of Lou Gehrig's Disease May 30, 2007
In a paper published in the June 1 issue of the Journal of Biological Chemistry, UK molecular and cellular biochemistry assistant professor Haining Zhu reports on how mutations in the gene that makes superoxide dismutase 1 (SOD1) slows down the intracellular transport of molecules in neurons. The results of the study by Zhu and his colleagues show that the defective transport of molecules is probably due to the aberrant interaction between the disease-causing SOD1 mutants and a motor complex... (Science Daily)
A close-up on pancreatic disease: How do we improve the odds? May 23, 2007
The team also assessed markers of oxidative stress [thiobarbituric acid reactive substances (TBARS), serum superoxide dismutase (s-SOD)] and antioxidant status [ferric reducing ability of plasma (FRAP), vitamins A, C and E, erythrocyte SOD (e-SOD), erythrocyte total glutathione (E-TGSH). According to the study results, antioxidant supplementation was effective in relieving pain related to CP, with reduced levels of oxidative stress and increases in antioxidant status. (EurekAlert!)
Scientists find elixir of eternal life May 4, 2007
Detailed work showed that the gene can boost levels of proteins called SODs (superoxide dismutase) which mop up free radicals, harmful chemicals linked with ageing. The researchers think that this may be a defence mechanism that helps the creatures tolerate starvation. (Telegraph.co.uk)
Amelioration of galactosamine-induced nephrotoxicity by a protein isolated from the leaves of the herb, Cajanus indicus L Apr 25, 2007
The activities of antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR) and glutathione-S-transferase (GST), levels of cellular metabolites, reduced glutathione (GSH), total thiols, oxidized glutathione (GSSG) and lipid peroxidation end products were determined to estimate the status of the antioxidative defense system. In addition, serum creatinine and urea nitrogen (UN) levels were also measured as a marker of nephrotoxicity. (BioMed Central)
Diseased Brain Cells More Involved In ALS-associated Motor Neuron Death Apr 18, 2007
D., co-director of the Center for Motor Neuron Biology and Disease, and his colleagues found that astrocytes expressing a mutated form of a gene, superoxide dismutase (SOD1), killed only the neurons that degenerate in ALS, not other types of neurons, and that this was due to a soluble toxic factor released by the astrocytes. If this toxic factor can be identified in future studies, this finding may offer novel strategies for ALS therapy. (Science Daily)
Study: astrocytes kill neurons in ALS Apr 17, 2007
The scientists found mutations in the gene for superoxide dismutase, or SOD1, cause some cases of ALS, in which progressive degeneration of motor neurons leads to paralysis and eventually death. Motor neurons degenerated and died when co-cultured with astrocytes expressing mutant SOD1, while mutant SOD1 in neurons, fibroblasts or microglia did not cause neuronal death. (United Press International)
Antioxidant Power Mar 23, 2007
The first source is the natural antioxidants your body produces like gluthathione, which protects cells from toxins and superoxide dismutase that breaks down superoxide into oxygen and hydrogen peroxide, which stops it from causing damage to cells. Another source of antioxidants is found in foods like fruits and leafy green vegetables. (Fox News)
Why Do Women Tend To Live Longer Than Men? Biologist's Model Offers New Ways To Study Gender Differences In Aging Feb 10, 2007
In 1999, Tower's graduate student, Jingtao Sun, showed that a gene for the antioxidant enzyme Cu/Zn-superoxide dismutase (SOD) led to a longer life span in male flies, but had a less dramatic impact in females ... In recent years, much of Tower's research on aging has focused on extending life span by manipulating genes that produce the cell's most powerful and ancient antioxidants -- the superoxidase dismutase (SOD) enzymes. (Science Daily)
Polymer Microparticles Show Promise As Ingenious New Druge Delivery System Jan 17, 2007
In a report scheduled for the Jan. 17 issue of ACS' Bioconjugate Chemistry, a bi-monthly journal, Georgia Tech's Niren Murthy and colleagues at Emory University School of Medicine describe successful cell culture experiments with microparticles encapsulating superoxide dismutase (SOD). That compound is getting wide attention as a potential treatment for inflammatory diseases because it scavenges reactive oxygen species. (Science Daily)
Antioxidant activity and hepatoprotective potential of agaro-oligosaccharides in vitro and in vivo Dec 2, 2006
In vivo studies of the antioxidant effects on tissue peroxidative damage induced by carbon tetrachloride in rat model indicated that agaro-oligosaccharides could elevate the activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and decrease the level of malondialdehyde (MDA), glutamate oxaloacetate transaminase (AST), glutamic pyruvic transaminase (ALT) significantly. At 400 mg/kg, MDA level reduced 44 % and 21 % in liver and heart, SOD and GSH-Px increased to highest in liver... (Nutrition Journal)
First international gene screen for typical ALS is on track Nov 29, 2006
In the decade since discovering the cause of some inherited forms of ALS-namely, a mutation producing a flawed version of the enzyme superoxide dismutase (SOD1)-a handful of other ALS-related mutations have been brought to light. The genetic underpinnings of sporadic ALS, however, are far less certain. (EurekAlert!)
Nanoparticle Shows Promise In Reducing Radiation Side Effects Nov 11, 2006
D., professor of radiation oncology at Jefferson Medical College of Thomas Jefferson University in Philadelphia and at Jefferson s Kimmel Cancer Center, and Ulrich Rodeck, M.D., professor of dermatology at Jefferson Medical College, compared DF-1 to two superoxidase dismutase mimetics, which are antioxidant drugs. They exposed zebrafish embryos to radiation with either DF-1 or a sod or amifostine. (Science Daily)
Intravenous Gene Therapy Protects Normal Tissue Of Mice During Whole-body Radiation Nov 10, 2006
In the study, mice were used to test the protective effects of manganese superoxide dismutase plasmid liposome (MnSOD-PL) gene therapy on the bone marrow during whole-body irradiation. The researchers found that in a control group of mice that received an initial 9 Gy dose of radiation there was 80 percent survival at 30 days compared to 93. (Science Daily)
New Process For Making Human Enzyme With Emerging Medical Uses Oct 27, 2006
The antioxidant enzyme superoxide dismutase (SOD) has attracted popular interest as a possible way of protecting tissues from damage that occurs in several major diseases. Demand for extracellular superoxide dismutase (ECSOD), the form of SOD that exists in blood and other body fluids, may increase in the future if further research confirms its potential value. (Science Daily)
Progression of Amyotrophic Lateral Sclerosis Oct 12, 2006
The only known genetic cause of the disease, which accounts for about 2% of cases, is a mutation in the gene encoding superoxide dismutase 1 (SOD1) protein. Therefore, the effect of mutant SOD1 has been intensely studied, with emphasis on the question of whether it causes cell-autonomous degeneration of motor neurons or, rather, compromises the function of other types of cells in the spinal cord (such as astrocytes and microglia), which, in turn, damages neurons. (New England Journal of Medicine)
Aqueous extract of Terminalia arjuna prevents carbon tetrachloride induced hepatic and renal disorders Sep 30, 2006
Antioxidant status in both the liver and kidney tissues were estimated by determining the activities of the antioxidative enzymes, superoxide dismutase (SOD), catalase (CAT) and glutathione-S-transferase (GST); as well as by determining the levels of thiobarbutaric acid reactive substances (TBARS) and reduced glutathione (GSH). In addition, free radical scavenging activity of the extract was determined from its DPPH radical quenching ability. (BioMed Central)
Breakthrough Offers New Tool For Studying Degenerative Disease Sep 29, 2006
Superoxide is efficiently removed by an enzyme, superoxide dismutase. Antioxidants in food, such as vitamin C and E, are also part of this process. (Science Daily)
Jumping Gene Could Provide Non-viral Alternative For Gene Therapy Sep 28, 2006
"One of our next goals is to use transposons to deliver a radio-protective gene, called manganese superoxide dismutase, to potentially protect normal tissue from radiation damage," Dr. Kaminski says. In cancer, he suspects gene therapy will focus on this type of modification of normal tissue for protective purposes as well as manipulating the immune response. (Science Daily)
Smokeless Tobacco Use Increases Cataract Risk Jul 26, 2006
Cadmium present in tobacco inactivates superoxide dismutase, an antioxidant, resulting in oxidant damage to the lens of the eye. SOURCE: British Journal of Ophthalmology, online July 12, 2006. (MEDLINEplus)
Antioxidants may slow vision loss Jul 20, 2006
Campochiaro and his team injected vitamin E, vitamin C, alpha-lipoic acid or an antioxidant similar to superoxide dismutase between the 18th and 35th day. In mice that received vitamin E or alpha-lipoic acid, 40 percent of the cones survived, about twice as many as in the control group or the groups treated with the other antioxidants, which had no identifiable effect. (EurekAlert!)
Mouse Study Shows Gene Therapy Provides Temporary Protection from Radiation Jun 5, 2006
Radiation oncologist Joel Greenberger of the University of Pittsburgh and his colleagues have been experimenting with a transgene--manganese superoxide dismutase plasmid liposome (MnSOD-PL)--that has shown the ability to protect cells from radiation in vitro. Tested in mice in specific organs, such as the lungs and bladder, the transgene conferred significant protection and is currently being tested in human lung cancer patients undergoing radiation therapy. (Scientific American)
The Da Vinci Code May 28, 2006
Just to sort out what you read at the desk, you want 1 shot of Chitinase, 1 shot of Dismutase and 1 shot of Catalase (1st, 2nd and 4th chemicals) and you'll have your mixture. Now look by a yellow toolbox and find the TOWEL. Combine the towel and the chemical. (IGN PS2)
Enzyme Defect Leads To Hyperinsulinism May 26, 2006
(August 17, 2005) -- A new study indicates that mutant Cu/Zn superoxide dismutase (SOD1) enzymes that are associated with an inherited form of Lou Gehrig's disease cause the protein to become sticky in tissues. Partial. (Science Daily)
News Tips from The Journal of Neuroscience Apr 18, 2006
CuZn superoxide dismutase (SOD1)mutations underlie some cases of familial amyotrophic lateral sclerosis (ALS) ... CuZn superoxide dismutase (SOD1)mutations underlie some cases of familial amyotrophic lateral sclerosis (ALS). (EurekAlert!)
New Family Of Biodegradable Polymers Shows Promise For Intracellular Drug Delivery Mar 31, 2006
One of the treatments is the delivery of superoxide dismutase, an enzyme that essentially detoxifies superoxide. Other applications include the use of polyketals in any type of protein-based vaccine, Murthy said, adding that researchers have not yet pursued this possibility. (Science Daily)
ActivBiotics, Inc. to Sponsor Satellite Symposium at 2006 ACC Meeting Mar 11, 2006
In additional to antibacterial programs, the Company has a second platform of anti-inflammatory oxygen free radical scavenging agents, which are small molecule mimetics of human superoxide dismutase. M-40403, the lead candidate among these, has been in Phase 2 trials. (PR Newswire)
MRI Drug May Improve Cancer-killing Ability Of Chemotherapy, Study Says Feb 17, 2006
Journal of the National Cancer Institute. " In an accompanying editorial, James H. Doroshow, M.D., of the National Cancer Institute, suggests that clinical trials may be the next approach for studies of drugs such as mangafodipir that affect oxidative stress in tumor cells. He writes, "Overall, this study contributes to our rapidly developing understanding of tumor cell [oxidation-reduction] balance and to the possibility that therapeutic approaches to the modulation of oxidant-mediated growth... (Science Daily)
