Adherex Announces Phase III Trial With STS in Collaboration With the Children's Oncology Group Mar 26, 2008
Eniluracil, an oral dihydropyrimidine dehydrogenase (DPD) inhibitor, is being developed to improve the tolerability and effectiveness of 5-fluorouracil (5-FU), one of the most widely used oncology drugs in the world. ADH-1 is a biotechnology compound which selectively targets N-cadherin, a protein present on certain tumor cells and the blood vessels of solid tumors. (CCNMatthews Press Releases)
Raptor Pharmaceuticals Corp. Enters Agreements to Advance Clinical Pipeline Mar 19, 2008
In addition to our ongoing clinical trial in cystinosis, we look forward to initiating a clinical trial of DR Cysteamine in NASH patients in 2008 (Canada Newswire)
Novel Mechanism That Regulates Carbon Dioxide Fixation In Plants Discovered Mar 6, 2008
There is a special relationship between two enzymes that are involved in the Calvin cycle -- phosphoribulokinase (PRK) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH). When light levels decrease, the two enzymes tend to stick together and therefore cannot function, thus slowing the Calvin cycle. (Science Daily)
Regular Drinking Raises Blood Pressure, Meta-Analysis Affirms Mar 5, 2008
" While the aldehyde dehydrogenase 2 (ALDH2) genotype is not associated with confounding factors, people who inherit two copies of the ALDH2 *2*2 variant tend to drink little because their body does not efficiently metabolize alcohol and they become flushed and nauseated after drinking, the researchers said. The meta-analysis included 10 studies reporting on associations between ALDH2 and hypertension or blood pressure. Most were cross-sectional; all were population-based. The studies were... (MedPage Today)
More on Medium-Chain Acyl-Coenzyme A Dehydrogenase Deficiencyin a Neonate Feb 7, 2008
NEJM -- More on Medium-Chain Acyl-Coenzyme A Dehydrogenase Deficiency in a Neonate ... More on Medium-Chain Acyl-Coenzyme A Dehydrogenase Deficiency in a Neonate ... 25 issue)1 report a severe neonatal presentation of medium-chain acyl coenzyme A dehydrogenase (MCAD) deficiency and suggest that newborn screening results should be communicated by 72 hours of age. (New England Journal of Medicine)
Identification of a subunit of NADH-dehydrogenase as a p49/STRAP-binding protein Jan 30, 2008
In the present study, we report that NDUFAB1, a nuclear encoded subunit of NADH dehydrogenase, represented the majority of the cDNA clones that interacted with p49/STRAP in multiple screenings using the yeast two-hybrid system. The p49/STRAP and NDUFAB1proteins interacted and colocalized with each other in the cell. (BioMed Central)
Gene Therapy Can Reduce Long-term Drinking Among Rodents Jan 8, 2008
7, 2008) Just as the risk of developing alcoholism is strongly influenced by genetic factors, mutations in gene coding -- such as the aldehyde dehydrogenase (ALDH2*2) allele -- also appear to protect against the risk ... "These individuals carry a genetic mutation that inactivates the aldehyde dehydrogenase-2 enzyme, which is needed to eliminate products of alcohol metabolism. When they drink, they experience nausea, facial redness and a pounding heart." Israel, past president of the U.S.... (Science Daily)
Xeloda(R), Taxotere(R) and Herceptin(R) Combination Study Suggests Clinical Benefit in Invasive Breast Cancer with Shortened Treatment Cycle Dec 16, 2007
Xeloda is contraindicated in patients who have a known hypersensitivity to 5-fluorouracil, and in patients with known dihydropyrimidine dehydrogenase (DPD) deficiency. Xeloda is contraindicated in patients with severe renal impairment. (PR Newswire)
New Marker To Identify Cancer Stem Cells Discovered Dec 13, 2007
In the new study, published in the November issue of Cell Stem Cell, the researchers found that cells from normal and cancerous breast tissue that had high levels of the enzyme aldehyde dehydrogenase activity, or ALDH, acted like breast stem cells. Further, of 577 human breast cancer tissue samples studied, those that expressed the specific form ALDH1 had the worst outcomes, suggesting this easily detected marker could be used to assess prognosis. (Science Daily)
Newsweek: Stifferconsequencesfor women drinkers Nov 26, 2007
Comment: This article seems to confuse anti diuretic hormone and alcohol dehydrogenase ... Alcohol dehydrogenase is an enzyme found in the digestive tract that does aid in the breakdown of alcohol, and women produce much much lower levels of alcohol dehydrogenase then men do, leading to smaller break down of the molecule and higher diffusion rates of alcohol into a womens blood stream. (MSNBC -- Health)
3-D Model Of Esophageal Cancer Created Nov 21, 2007
A new study found that alcohol dehydrogenase 2 (ADH2) and aldehyde dehydrogenase 2 (ALDH2) genotypes are associated with esophageal cancer risk in. (May 31, 2006) Two new Mayo Clinic studies draw attention to the risk factors and possible genetic basis for Barrett's esophagus and esophageal cancer (adenocarcinoma). (Science Daily)
Adherex and the International Childhood Liver Tumour Strategy Group (SIOPEL) Announce the Launch of a Phase III Trial of STS Oct 30, 2007
Eniluracil, an oral dihydropyrimidine dehydrogenase (DPD) inhibitor, was previously under development by GlaxoSmithKline for oncology indications. ADH-1, our lead biotechnology compound, selectively targets N-cadherin, a protein present on certain tumor cells and established blood vessels that feed solid tumors. (CCNMatthews Press Releases)
Medium Chain Acyl–Coenzyme A Dehydrogenase Deficiency in a Neonate Oct 25, 2007
NEJM -- Medium Chain Acyl-Coenzyme A Dehydrogenase Deficiency in a Neonate ... Medium Chain Acyl Coenzyme A Dehydrogenase Deficiency in a Neonate ... To the Editor: Medium-chain acyl coenzyme A dehydrogenase (MCAD) deficiency is the most frequently diagnosed defect in mitochondrial beta-oxidation, with a prevalence of 1 case per 15,000 persons in the United States. (New England Journal of Medicine)
Bennu Pharmaceuticals Inc. Oct 23, 2007
It is meant as a treatment for aldehyde dehydrogenase deficiency, which is a genetic metabolic disorder. Raptor will continue to handle early research and development, while Bennu will pick up drugs in the middle of their clinical development and move them through the pipeline. (San Francisco Business Times, CA)
Raptor Pharmaceuticals Acquires Initial Clinical Program Establishes Subsidiary to Develop Clinical Phase Drugs Oct 22, 2007
Bennu will focus initially on a product targeting aldehyde dehydrogenase ("ALDH2") deficiency, a genetic metabolic disorder ... Bennu's initial clinical program includes the treatment of aldehyde dehydrogenase ("ALDH2") deficiency. (Canada Newswire)
Screening for Metabolic Disorder Cost Effective Sep 28, 2007
MCADD, or medium chain acyl-CoA dehydrogenase deficiency, is an inherited disorder caused by the lack of an enzyme needed to convert fat to energy. If not detected early, the disorder results in death rates as high as 26 percent. (MEDLINEplus)
Antibiotics share killing mechanism Sep 7, 2007
R.B. Helling and J.S. Kukora, "Nalidixic acd-resistant mutants of Escherichia coli deficient in isocitrate dehydrogenase," Journal of Bacteriology, March 1971. M.J. Gruer et al., "Construction and properties of aconitase mutants of Escherichia coli," Microbiology, June 1997. (The Scientist)
Sony powers Walkman with sugar bio battery Aug 25, 2007
The battery casing is made from vegetable-based polylactate plastic while the enzymes used are glucose dehydrogenase and diaphorase. The enzymes digest the glucose and release hydrogen ions, along with free electrons. (TG Daily)
Reversing The Signs Of Alzheimer's Aug 7, 2007
The amyloid protein inflicts damage by interacting with an enzyme called ABAD (Amyloid Beta Alcohol Dehydrogenase) and releasing toxic substances which kill brain cells. Dr Gunn-Moore's research initially focussed on developing the three-dimensional shape of ABAD and understanding how amyloid attaches itself to the structure. (Science Daily)
Weight Gain May Be Rooted in Liver Enzyme Defect Aug 4, 2007
The reduction in fat burning capacity is tied to a lack of two liver enzymes -- CD36 and acyl-coenzyme A dehydrogenase, the researchers said. CD36 is responsible for transferring fat into liver cells while the second enzyme begins the oxidation process. (Health-Finder)
Metabolic Defect In Liver Can Lead To Obesity Jul 27, 2007
One, CD36, is responsible for transferring fat fuels into liver cells, while the second enzyme, acyl-coenzyme A dehydrogenase, begins the oxidation process in mitochondria. When fed a high-fat diet, the obesity-prone rats overate and became obese, gaining 36% more weight than resistant animals. (Science Daily)
Step closer to 'Holy Grail' cure for Alzheimer's Jul 24, 2007
The amyloid latches on to an enzyme called Amyloid Beta Alcohol Dehydrogenase (ABAD) and switches it off. The researchers at St Andrews developed a three-dimensional shape of ABAD to understand how amyloid attaches itself. (Telegraph.co.uk)
Alzheimer's hope as Scots researchers find way to reverse disease Jul 24, 2007
The amyloid protein causes damage by interacting with an enzyme called amyloid beta alcohol dehydrogenase (ABAD) and releasing toxic substances which kill brain cells. Researchers at St Andrews initially focused on developing the three-dimensional shape of ABAD and understanding how amyloid attached itself to the structure. (Scotsman)
People Get Drunk Faster After Bariatric Surgery, New Study Jun 17, 2007
In particular, the authors point to the decrease in dehydrogenase, the enzyme that metabolizes alcohol and is mostly found in the liver and the stomach. Another possible area to be concerned about, said Morton, is that the social relaxation they experience when drinking alcohol also happens inside the post- operative patient's body. (Medical News Today)
ASBS: Alcohol Effects Altered after Bariatric Surgery Jun 16, 2007
All of the factors involved in alcohol metabolism -- weight, liver function, food intake, and production of the enzyme alcohol dehydrogenase -- are "profoundly altered" by gastric bypass surgery, he said. But only one prior study from Sweden had looked at the issue, and only in 11 women. (MedPage Today)
Bariatric Surgery Can Make People More Sensitive To Alcohol, Surgeon Finds Jun 16, 2007
Gastric bypass alters a number of physiological functions in the body that may explain this change, in particular a decrease in the enzyme alcohol dehydrogenase, which is most responsible for alcohol metabolism and is also most present in the liver and the stomach. Another cause for concern, Morton pointed out, is that not only do patients get more relaxed socially from drinking alcohol, but this relaxation also happens inside the body. (Science Daily)
Patients' prescription for doctors: a dose of respect Jun 16, 2007
In particular, he said, the enzyme alcohol dehydrogenase, which is most responsible for alcohol metabolism, is markedly reduced after the operation. "Patients have to be careful with alcohol because they'll become tipsy a lot easier," Dr. Morton said, adding that the high number of calories in alcohol is another good reason to abstain. (Globe and Mail)
S-1, a Novel Oral Fluoropyrimidine, When Combined With Cisplatin, Demonstrates Significant Improvement in Overall Survival of Advanced Gastric Cancer Patients Over S-1 Alone Jun 4, 2007
About S-1 S-1 is a novel oral fluoropyrimidine that combines 3 pharmacological agents: Tegafur, which is a pro-drug of 5 fluorouracil; gimeracil (5-chloro- 2,4 dihydropyridine, CDHP) which inhibits dihydropyrimidine dehydrogenase (DPD) enzyme; and oteracil (potassium oxonate, Oxo) a gastrointestinal side effects corrector. S-1 is currently marketed in Japan for the treatment of gastric, colorectal, head and neck, non-small cell lung, metastatic breast and pancreas cancers. (PR Newswire)
Adherex to Present ADH-1 and Eniluracil Data at 2007 ASCO Meeting Jun 4, 2007
"Elucidating the mechanisms responsible for the previous failure of phase III clinical trials with eniluracil (EU) and development of a novel scheduling approach to optimize the efficacy of EU/5-fluorouracil (5-FU) combination therapy." Poster Number B13, Abstract No. 2557 by V. Guarcello, J. Fourie, M.J. Lawton, W.P. Peters, M.J. Heslin and R.B. Diasio to be presented today from 8:00 AM to 12:00 PM. As previously hypothesized by Adherex, this study demonstrates, that eniluracil produces... (CCNMatthews Press Releases)
Avalon Pharmaceuticals Closes $20 Million in Private Placement of Common Stock and Warrants to Institutional Investors May 30, 2007
About AVN944 AVN944 is an oral small molecule drug candidate that inhibits inosine monophospate dehydrogenase (IMPDH), an enzyme that is critical for cells to be able to synthesize guanosine triphosphate (GTP), a molecule required for DNA synthesis and cellular signaling. Avalon filed an IND with the FDA in August 2005 and initiated U.S. Phase I clinical trials in January 2006 for use of AVN944 for the treatment of hematological cancers. (PR Newswire)
QLT USA, Inc. files Aczone(TM) labeling supplement for removal of blood screening requirement May 29, 2007
VANCOUVER, May 29 /PRNewswire-FirstCall/ - QLT Inc. (NASDAQ: QLTI; TSX: QLT) announced today that QLT USA, Inc. submitted a labeling supplement (sNDA) for Aczone(TM) to the U.S. Food and Drug Administration (FDA) to request the removal of the gluceose-6-phosphate dehydrogenase (G6PD) screening and blood monitoring requirements from its current label. The sNDA is primarily based on the Phase IV clinical trial completed in 56 safety-evaluable G6PD-deficient patients (see related press-release... (PR Newswire)
Pregnant women are told: Don't drink at all May 26, 2007
STING'S HEALING REMEDY. On the eve of their reunion tour, Sting reveals why the Police ended their feuding. (Daily Mail)
Great Bugs of Fire - Volcano Loving Bugs May 19, 2007
An enzyme, alcohol dehydrogenase (ADH), is derived from a member of the archaea called Sulfolobus solfataricus. It works under some of nature's harshest volcanic conditions: It can survive to 88 deg. (FirstScience.com)
Hearts of male and female rainbow trout are different Apr 30, 2007
The researchers examined if two regulatory molecules found in the fish heart -- citrate (an acid which inhibits the glycolytic metabolic pathway) and pyruvate dehydrogenase (PDH), the enzyme allowing carbohydrates to be oxidized -- differ between the sexes. The researchers hypothesized that male hearts would have higher citrate levels and females would benefit more from the stimulation of PDH than males. (EurekAlert!)
Party-goers strive to get rid of 'glow' Apr 26, 2007
In most people, an enzyme known as aldehyde dehydrogenase 2 (ALDH2) breaks down acetaldehyde. Some Asian-Americans, however, have a deficiency in the enzyme, which causes them to break down acetaldehyde at a much slower rate. (AZCentral -- Entertainment)
Moonlighting Enzyme Linked To Neurodegenerative Disease Apr 26, 2007
A new Mayo Clinic study published in the April issue of the Proceedings of the National Academy of Sciences (PNAS) shows that mutations in a moonlighting enzyme, dihydrolipoamide dehydrogenase (DLD), are responsible for decreasing the enzyme's primary role as a metabolizer, while increasing its role in breaking down frataxin, its second job. Moonlighting proteins and enzymes are molecules that perform two or more different functions. (Science Daily)
Lessening Hot Flashes: Exploring The Role Of Genes, Obesity And Alcohol Apr 26, 2007
The research team identified a second polymorphism, in a gene encoding an enzyme, 3-beta-hydroxysteroid dehydrogenase, which also is associated with an increase in hot flashes. People typically didn t think of hot flashes as having a genetic component, Flaws said. (Science Daily)
Supervised multivariate analysis of sequence groups to identify specificity determining residues Apr 24, 2007
Two of these test cases, the Lactate/Malate dehydrogenase family and Nucleotidyl Cyclases, consist of two functional groups. The other family, Serine Proteases consists of three groups. (BioMed Central)
Elite corps of doctors, nurses address CCC Mar 31, 2007
Ethanol perturbs Aldehyde dehydrogenase enzyme mRNA expression in medaka embryo by Dr. Asok Dasmahapatra from the National Center for Natural Product Research, and Health Ahead/Heart Smart by Dr. Gerald Berenson of Tulane University. Poster exhibits will be include presenters from 11:30 a.m. to 1 p.m. Scheduled are exhibits on the Persistence of Antiobiotic Resistant Enteric Bacteria in Freshwater Wetland Environments by Andrekeus Lee of the University of Mississippi; the Differences in the... (Clarksdale Press Register, MS)
Rare alleles for poison protection in Africa Mar 22, 2007
Sequence variation in human succinate dehydrogenase genes: evidence for long-term balancing selection on SDHA Bora E Baysal , Elizabeth C Lawrence and Robert E Ferrell ... SDHA encodes the major catalytical subunit (flavoprotein, Fp) of succinate dehydrogenase enzyme complex (SDH; mitochondrial complex II). (BioMed Central)
News tips from the Journal of Neuroscience Mar 21, 2007
The authors visualized SCb transport in live hippocampal neurons transfected with combinations of three fluorescently tagged SCb proteins: -synuclein, synapsin-I, and glyceraldehyde-3-phosphate dehydrogenase, as well as the FC protein synaptophysin. A direct comparison of -synuclein and synaptophysin transport revealed that SCb transport was much slower overall, but it had a herky-jerky quality, and its instantaneous velocity was surprisingly comparable with FC. Like SCa transport, the... (EurekAlert!)
Seeking the Connections: Alcoholism and Our Genes Mar 19, 2007
By the 1980s investigators traced the reaction to an enzyme involved in alcohol metabolism, aldehyde dehydrogenase, and eventually to the gene that encodes it, ALDH1. The enzyme breaks down acetaldehyde, but slight variations in the gene's DNA code in these subjects caused the enzyme to work more slowly. (Scientific American)
G6PD Deficiency Is Associated With Significant Protection Against Severe, Life-threatening Malaria Mar 14, 2007
A case-control study in two populations in Mali, West Africa has shown that glucose-6-phosphate dehydrogenase (G6PD) deficiency is associated with significant protection against severe, life-threatening malaria. Researchers from the US National Institute of Allergy and Infectious Diseases and the University of Bamako, Mali, led by Thomas E. Wellems, report the findings this week in the journal PLoS Medicine. (Science Daily)
1 fight won, but war rages Feb 20, 2007
citation needed] At the level of the citric acid cycle, arsenic inhibits succinate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. (Pensacola News Journal)
Avalon Pharmaceuticals Announces Positive Interim Results for AVN944 Phase I Trial Dec 14, 2006
"The fact that we have not seen any drug-related serious adverse events, combined with several indications of biological drug effects and disease stabilization in multiple patients indicates that there will likely be a good therapeutic window from which to establish an effective treatment protocol. Based on pre-clinical data and the positive trends that we have seen thus far in the Phase I, we believe that the immediately upcoming dose levels in the Phase I trial should provide sufficient... (PR Newswire)
'Smart women' program launched Nov 8, 2006
Women process alcohol differently than men because they have less of the enzyme alcohol dehydrogenase, LaSalle said. "Basically, women do not break down alcohol as fast as men when it's consumed," she said. (Daily Collegian, PA)
New Evidence On Why Alcohol Consumption Is A Risk Factor For Cancer Nov 1, 2006
They found that those patients with a variation in the aldehyde dehydrogenase gene also had increased amounts of the kind of DNA damage that can lead to cancer ... Individuals with the gene variant produce little aldehyde dehydrogenase and high levels of acetaldehyde build up in their blood after alcohol consumption. (Science Daily)
The Straight Dope® Oct 20, 2006
When the liver processes ethanol, the enzyme alcohol dehydrogenase first converts it to acetaldehyde. In most people a second enzyme, aldehyde dehydrogenase (ALDH), quickly converts the acetaldehyde to harmless acetate. (City Pages)
Popular Anti-Aging Supplement Found Useless Oct 19, 2006
By Judith Groch, Senior Writer, MedPage Today Reviewed by October 18, 2006. Oct. 18 -- The widely used anti-aging supplement DHEA (dehydroepiandrosterone) has no beneficial effect on body composition, physical performance, insulin sensitivity, or quality of life, according to Mayo Clinic researchers. (MedPage Today)
Plasma membrane calcium ATPase (PMCA4): A housekeeper for RT-PCR relative quantification of polytopic membrane proteins Sep 18, 2006
No one gene has emerged as a universal reference gene, and much debate surrounds some of the more commonly used reference genes, such as glyceraldehyde-3-phosphate dehydrogenase (GAPDH). At this time, no gene encoding for a plasma membrane protein serves as a reference gene, and relative quantification of plasma membrane proteins is performed with genes encoding soluble proteins, which differ greatly in quantity and in targeting and trafficking from plasma membrane proteins. (BioMed Central)
Alcoholism an illness that can be inherited Sep 10, 2006
Experts have found there are at least two known groups of gene mutations, called alcohol dehydrogenase and aldehyde dehydrogenase, that affect how people metabolise alcohol. The Queensland Institute of Medical Research's Professor Nick Martin said its evidence showed the genes were also important in people of European extraction. (Sydney Morning Herald -- Australia)
Gene-on-gene interactions may influence risk for developing alcoholism Aug 28, 2006
One variant of the alcohol dehydrogenase gene can influence alcohol response among some Caucasians ... One variant of the alcohol dehydrogenase (ADH) gene the ADH1B genotype appears to be able to influence level of response (LR) to alcohol among non-Asians ... One group of mutations is in an enzyme called aldehyde dehydrogenase (ALDH) and the other group is in the ADH enzyme. (EurekAlert!)
Inherited Metabolic Disorder More Common Than Thought Aug 24, 2006
People with SCADD (short-chain acyl-coenzyme A dehydrogenase deficiency) aren't able to oxidize fatty acids because a certain enzyme is missing or not functioning properly. This can result in developmental delay, low blood sugar levels (hypoglycemia), and epilepsy, according to background information in the study. (MEDLINEplus)
Development and evaluation of different normalization strategies for gene expression studies in Candida albicans biofilms by real-time PCR Aug 5, 2006
The eight genes tested in this study are ranked according to their expression stability (from most stable to least stable) as follows: ACT1 (beta-actin)/PMA1 (adenosine triphosphatase), RIP (ubiquinol cytochrome-c reductase complex component), RPP2B (cytosolic ribosomal acidic protein P2B), LSC2 (succinyl-CoA synthetase beta-subunit fragment), IMH3 (inosine-5'-monophosphate dehydrogenase fragment), CPA1 (carbamoyl-phosphate synthethase small subunit) and GAPDH (glyceraldehyde-3-phosphate... (BioMed Central)
US Patent Granted for 4SC's Clinical Project Jul 27, 2006
DHODH inhibitors DHODH inhibitors block the protein DHODH (dehydro-orotate dehydrogenase), which plays an important role in the biosynthesis of pyrimidines, and thus the proliferation of rapidly dividing cells, especially of lymphocytes, a key cell in the immune response of the body. 4SC AG has already been successful in advancing one DHODH inhibitor, a substance named SC12267, from research into clinical development. (PR Newswire)
Newborn blood test offers hope after pilot study Jul 25, 2006
The disease, Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCADD), affects around 70 babies born each year and prevents them from accessing fat stores in the body. It can result in sudden illness or death if not recognised early, but can be treated with a careful diet. (Guardian Unlimited -- UK)
Duke scientists find way to grow stem cells in laboratory Jul 23, 2006
In their study, the investigators discovered that an enzyme, aldehyde dehydrogenase (ALDH), stimulates blood stem cells to mature and transform into blood or immune cells, a process called differentiation. They inhibited this enzyme in stem cell cultures and successfully increased the number of stem cells 3. (Herald Sun)
Twins Study Spots Three Rheumatoid Arthritis Genes Jul 14, 2006
The other over-expressed genes were 11B-hydroxysteroid dehydrogenase type 2 (11B-HSD2) -- a steroid pathway enzyme linked to inflammation and bone erosion -- and cysteine-rich, angiogenic inducer 61 (Cyr61), which plays a role in the formation of new blood vessels. The study was published in the July issue of the journal Arthritis atism. (MEDLINEplus)
Newborns Tested for Genetic Diseases Jul 12, 2006
Back then, there was no real way to detect the disorder, known as medium chain Acyl-Co-A dehydrogenase deficiency, or MCADD for short. But today, the technology now exists to screen for MCADD and other similar genetic disorders using just a few drops of blood taken from a newborn baby. (ABC News)
Expression of target and reference genes in Daphnia magna exposed to ibuprofen Jul 8, 2006
As a robust approach, we used a combination normalisation factor (NF), calculated using the geNorm application, based on the geometric mean of three selected reference genes: glyceraldehyde-3-phosphate dehydrogenase, ubiquitin conjugating enzyme and actin. The effects of normalisation are illustrated using as target gene leukotriene B4 12-hydroxydehydrogenase (Ltb4dh), which was up-regulated following 24 h exposure to 63-81 mg IB/l. (BioMed Central)
New genes implicated in rheumatoid arthritis Jun 27, 2006
The second most significantly over-expressed gene was 11-hydroxysteroid dehydrogenase type 2 (11-HSD2), a steroid pathway enzyme linked to inflammation and bone erosion. This gene was also found over-expressed in the synovial tissue of OA patients. (EurekAlert!)
Personality and parents' alcoholism interact to influence a person's risk of becoming an alcoholic Jun 26, 2006
"This indicates that family history by itself is only one of many variables in the 'equation' predicting alcoholism. Some variables increase the probability of alcoholism in offspring, such as exposure to heavy drinking, or antisocial behavior in parents or offspring, whereas others decrease this risk, such as warm parent-child relationships and certain forms of the alcohol dehydrogenase gene. This study suggests that an individual's personality influences how he or she responds to familial... (EurekAlert!)
- Johnjoe McFadden Jun 6, 2006
David Leys, Nigel Scrutton, Michael Sutcliffe and colleagues at Manchester University, together with Adrian Mulholland at Bristol, have just published a paper in the journal Science that claims that an enzyme called aromatic amine dehydrogenase (AADH) accelerates its chemical reaction by bringing the substrate particles so close to the enzyme that the fog of particle positions overlaps, allowing a proton to "quantum tunnel" from substrate to enzyme. That biochemical reactions involve quantum... (Guardian Unlimited)
Data to be presented on Adherex's Eniluracil at ASCO 2006 Annual Meeting Jun 5, 2006
D., Adherex's Chairman and CEO, said, "Thus far, every aspect of our hypothesis for why GSK's Phase III trials failed has turned out to be correct. In our Phase I trial, we have already demonstrated that a dose of eniluracil one-tenth of that used by GSK effectively inhibits dihydropyrimidine dehydrogenase (DPD) for 48-72 hours. We have been able to increase the dose of 5-FU by 20-fold over the dose used by GSK and believe we are close to identifying the optimal dose. And, as was demonstrated in... (CCNMatthews Press Releases)
Enzyme defect leads to hyperinsulinism May 25, 2006
Bethesda, MD A recent study in the Journal of Biological Chemistry confirms that mutations in an enzyme called glutamate dehydrogenase can cause congenital hyperinsulinism ... One of these genes codes for an enzyme called glutamate dehydrogenase ... This enzyme is stimulated by the amino acid leucine, meaning that protein meals that contain leucine lead to activation of glutamate dehydrogenase, which in turn triggers the release of insulin from pancreatic cells. (EurekAlert!)
