Kudzu Compound Could Help Alcoholics Quit Drinking Nov 18, 2009
The synthetic daidzin inhibits an enzyme called aldehyde dehydrogenase 2 (ALDH-2). This promotes the buildup of an organic compound called acetaldehyde. (W-USA News, DC)
Illegal Steroids Still for Sale Oct 23, 2009
A blood clot in the legs (deep vein thrombosis, or DVT)Kidney stonesErosion of the teeth (seen with long-term use of chewable vitamin C tablets)Worsening of sickle cell diseaseHemolysis (destruction of red blood cells) in people with glucose 6-phosphate dehydrogenase deficiencyIncreased aluminum absorption into the body (which can be especially dangerous for people with kidney disease)Signs of an allergic reaction, such as. An unexplained rashItchingHivesSwelling of the mouth or... (CBS News -- Evening News)
New Approach For The Treatment Of Malignant Brain Tumors Oct 3, 2009
With the aid of extensive molecular pathology studies of extirpated tumor tissue, the researchers identified a new prognosis factor called IDH1 mutation (gene mutation of isocitrate dehydrogenase). It is indicative, irrespective of the type of tissue of the anaplastic glioma and irrespective of treatment, of a better prognosis. (Science Daily)
Asparagus Could be New Hangover Cur... Aug 19, 2009
In addition, two key enzymes that metabolize ethanol alcohol dehydrogenase and aldehyde dehydrogenase were more than twice as effective in the presence of the asparagus leaf and shoot extracts. These results provide evidence of how the biological functions of asparagus can help alleviate alcohol hangover and protect liver cells, Dr Kim said. (Suite101.com)
Bayer Statement on U.S. Food and Drug Administration Advice for Patients: Serious Errors with Certain Blood Glucose Monitoring Test Strips Aug 14, 2009
TARRYTOWN, N.Y., Aug. 13 /PRNewswire/ -- Since 2006, Bayer Diabetes Care has not distributed test strips that use GDH-PQQ (glucose dehydrogenase pyrroloquinoline quinone) glucose monitoring technology for its blood glucose meters. As referenced in a U.S. Food and Drug Administration Advice for Diabetic Patients and their Caregivers issued today, blood glucose meters that use GDH-PQQ technology may "produce a falsely high (elevated) blood glucose result.". (PR Newswire)
Synthetic Derivative Of Kudzu Vine Can Reduce Drinking And Prevent Relapse Aug 14, 2009
Daidzin inhibits human aldehyde dehydrogenase 2 (ALDH-2), which metabolizes alcohol into acetaldehyde. Inhibiting ALDH-2 promotes the accumulation of acetaldehyde, which has aversive effects. (Science Daily)
Savient Pharmaceuticals Receives Complete Response Letter from U.S. Food and Drug Administration for KRYSTEXXA(TM) Aug 3, 2009
A Communication Plan directed to healthcare providers likely to prescribe KRYSTEXXA to support the dissemination of information about the risks of severe infusion reactions and possible anaphylaxis, the risk of severe adverse reactions in administering KRYSTEXXA to patients with glucose-6-phopshate dehydrogenase (G6PD) deficiency and major cardiovascular events, and. An Assessment Plan to monitor and assess the effectiveness of the Medication Guide and Communication Plan in communicating to... (PR Newswire)
Population Study of 1311 C/T polymorphism of Glucose 6 Phosphate Dehydrogenase gene in Pakistan- an analysis of 715 X-chromosomes Jul 30, 2009
Other articles by authors. Related articles/pages. (BioMed Central)
Gene Mutation Responsible For Hereditary Neuroendocrine Tumor Discovered Jul 24, 2009
Of the four familial PGL syndromes, three forms have previously been associated with mutations in genes of the succinate dehydrogenase (SDH) complex, an enzyme complex involved in the ability of cells to extract energy from nutrients ... 27, 2008) Individuals who have a germline mutation in the succinate dehydrogenase subunit B (SDHB) gene presented with familial renal cell cancer (RCC) or with bilateral RCC, according to an article in the. (Science Daily)
Genes And The Environment Interact To Influence Adolescent Alcohol Use Jul 21, 2009
3, 2009) The two genes that have the strongest associations with alcohol use and alcohol dependence are mitochondrial aldehyde dehydrogenase 2 and alcohol dehydrogenase IB. Mutations of these genes are. (Nov. (Science Daily)
Key To Maintaining Embryonic Stem Cells In Lab Jul 14, 2009
The gene controls the production of the threonine dehydrogenase (TDH) enzyme in mouse ES cells. This enzyme breaks down an amino acid called threonine into two products. (Science Daily)
Scientists sequence genome of the N2-fixing, soil-living bacterium Azotobacter vinelandii Jun 18, 2009
Genome analysis helped pinpoint the chromosomal location of the three known oxygen-sensitive nitrogenases, as well as the genes that code for other oxygen-sensitive enzymes such as carbon-monoxide dehydrogenase and a formate dehydrogenase. The sequence also provided important information on the genes that code for alginate, a polymer that further protects the organism from excess oxygen by forming a physical barrier around the bacterium. (EurekAlert!)
American Chemical Society's Weekly PressPac -- May 13, 2009 May 18, 2009
Interestingly, plants from contaminated fields produced one-third more of a protective protein called betaine aldehyde dehydrogenase the same protein known to protect human blood from radiation damage. ARTICLE #3 FOR IMMEDIATE RELEASE "Proteomic Analysis of Mature Soybean Seeds from the Chernobyl Area Suggest Plant Adaptation to the Contaminated Environment". (EurekAlert! -- Business News)
Alcohol flush 'shows cancer risk' Apr 14, 2009
Alcohol-induced flush is predominantly down to an inherited deficiency in an enzyme called aldehyde dehydrogenase 2 (ALDH2). Although this is widely known, few are aware of the accumulating evidence that ALDH2-deficient individuals are at much higher risk of oesophageal cancer from alcohol consumption, say the researchers. (BBC News -- UK)
Frogs reveal clues about the effects of alcohol during development Apr 6, 2009
The researchers, at the Hebrew University in Israel, found that shutting down a molecule needed to produce retinoic acid, called retinaldehyde dehydrogenase or RALDH2, increased sensitivity of developing embryos to low doses of alcohol ... The report, titled: Ethanol induces embryonic malformations by competing for the retinaldehyde dehydrogenase activity during vertebrate gastrulation is published in the May/June 2009 issue of the research journal, Disease Models nisms (DMM), published by The... (EurekAlert!)
Enzyme and vitamin define the yin and yang of asthma Mar 30, 2009
Mice that lack MMP7 were found to have higher production of retinal dehydrogenase, an enzyme that is responsible for synthesizing vitamin A in the lung. MMP7 deficient mice showed less lung inflammation when they are exposed to allergens than did mice who had enough MMP7. (EurekAlert!)
Flushing from Alcohol a Risk Factor for Esophageal Cancer Mar 26, 2009
Facial flushing, nausea and increased heart rate when drinking alcohol occurs in about a third of East Asians (Chinese, Japanese and Koreans), mainly due to an inherited deficiency in an enzyme called aldehyde dehydrogenase 2 (ALDH2). There is increasing evidence that people with this deficiency are at much higher risk for alcohol-related esophageal cancer (specifically squamous cell carcinoma) than people with fully active ALDH2, the experts wrote in an article in this week's issue of PLoS... (MEDLINEplus)
Alcohol-Induced Flushing a Cancer Risk Mar 25, 2009
This so-called "alcohol flushing response" is predominantly due to an inherited deficiency in an enzyme called aldehyde dehydrogenase 2 (ALDH2). Although clinicians and the East Asian public generally know about the alcohol flushing response, few are aware of the accumulating evidence that ALDH2-deficient individuals are at much higher risk of esophageal cancer (specifically squamous cell carcinoma) from alcohol consumption than individuals with fully active ALDH2. (Newsmax)
Facial flushing drinkers at higher cancer risk Mar 25, 2009
The study said about a third of East Asians -- Chinese, Japanese and Koreans -- have an enzyme deficiency called aldehyde dehydrogenase 2 that results in problems in metabolizing alcohol, accompanied by a flushing face, nausea and a rapid heartbeat. This trait puts them at higher risk of developing esophageal cancer, an especially deadly type with five-year survival rates of 12 to 31 percent. (Xinhuanet, China)
Licorice compound offers new cancer prevention strategy Mar 24, 2009
In the study published in the Journal of Clinical Investigation, Raymond Harris, M.D., Ming-Zhi Zhang, M.D., and colleagues show that inhibiting the enzyme 11 -hydroxysteroid dehydrogenase type 2 (11 HSD2) either by treatment with a natural compound found in licorice or by silencing the 11 HSD2 gene prevents colorectal cancer progression in mice predisposed to the disease. Colorectal cancer is the second leading cause of cancer deaths in the United States. (EurekAlert!)
The Dangers of Eating Too Much Lico... Mar 23, 2009
The active ingredient in licorice, glycyrrhentinic acid, inhibits renal 11 hydroxysteroid dehydrogenase causing stimulation of the mineral corticoid receptor by cortisol, leading to a hyperminerocoticoid state ... 11- hydroxysteroid dehydrogenase isozymes are mostly found in the liver and adipose tissue (type 1), and catalyse the conversion of cortisol to cortisone ... Glycyrrhetnic acid found in licorice inhibits renal 11 hydroxysteroid dehydrogenase allowing cortisol to stimulate... (Suite101.com)
Acetaldehyde In Alcohol: 'Hangover Chemical' May Be Overlooked Risk Factor For Cancer Mar 21, 2009
7, 2009) Chronic drinking is a known risk factor for colorectal cancer, possibly due to the creation of acetaldehyde by the alcohol dehydrogenase enzyme. New findings show that individuals with a polymorphism. (Science Daily)
An optimised system for refolding of human glucose 6-phosphate dehydrogenase Mar 12, 2009
Human glucose 6-phosphate dehydrogenase (G6PD), active in both dimer and tetramer forms, is the key entry enzyme in the pentose phosphate pathway (PPP), providing NADPH for biosynthesis and various other purposes, including protection against oxidative stress in erythrocytes. Accordingly haemolytic disease is a major consequence of G6PD deficiency mutations in man, and many severe disease phenotypes are attributed to G6PD folding problems. (BioMed Central)
High Novelty-seeking And Low Avoidance Of Harm Contribute To Alcohol Dependence Mar 5, 2009
Researchers examined a group of AD individuals with the inactive form of aldehyde dehydrogenase-2 (ALDH2) persons who would normally have a low incidence of alcoholism because the inactive form of ALDH2 causes flushing, nausea, and headaches ... A new study found that alcohol dehydrogenase 2 (ADH2) and aldehyde dehydrogenase 2 (ALDH2) genotypes are associated with esophageal cancer risk in ... 7, 2008) Certain genetic factors may both increase and protect against the risk of developing... (Science Daily)
New study shows how spikes in nitrite can have Mar 4, 2009
"The proteins we have implicated include some key proteins, such as mitochondrial aldehyde dehydrogenase, that have been shown by others to be critical to cardiac protection afforded by other agents and triggers," added Perlman. "This is exciting because it ties nitrite-triggered cardioprotection into the broader preconditioning field. Our study complements and extends other work, and identifies new players of potential importance for protection of the heart.". (EurekAlert!)
Newly Discovered Gene Could Be A Prime Target In The Most Lethal Brain Cancer Feb 20, 2009
Patients that have mutation of the genes, isocitrate dehydrogenase 1, gene 1 and 2 (IDH1 and IDH2), also had a longer survival time. Because the researchers found this genetic mutation in several different stages of glioma development, "the results suggested that the IDH mutations are the earliest genetic changes that start glioma progression," said Darell Bigner, M.D., Ph. (Science Daily)
Metabolic Enzymes as Oncogenes or Tumor Suppressors Feb 19, 2009
In this issue of the Journal, Yan and colleagues3 report that 70% or more of low-grade gliomas bear mutations in one of two NADP+-dependent isocitrate dehydrogenase enzymes (IDH1 and IDH2). . (New England Journal of Medicine)
IDH1 and IDH2 Mutations in Gliomas Feb 19, 2009
Background A recent genomewide mutational analysis of glioblastomas (World Health Organization [WHO] grade IV glioma) revealed somatic mutations of the isocitrate dehydrogenase 1 gene (IDH1) in a fraction of such tumors, most frequently in tumors that were known to have evolved from lower-grade gliomas (secondary glioblastomas) ... Conclusions Mutations of NADP+-dependent isocitrate dehydrogenases encoded by IDH1 and IDH2 occur in a majority of several types of malignant gliomas. (New England Journal of Medicine)
Discovery Fleshes Out Metabolism Of Key Environmental And Energy Bacteria Feb 12, 2009
"Since this is the first multi-protein lactate dehydrogenase found in bacteria, we had to prove that all three proteins worked together." ... Together, the three proteins make up an enzyme called L-lactate dehydrogenase ... Until this discovery, researchers had only found examples of L-lactate dehydrogenase made up of one protein, setting Shewanella's enzyme apart. (Science Daily)
