Triggers Found In Cells' Transition From Colitis To Cancer Oct 15, 2009
(May 26, 2009) Researchers have found that increased expression of a form of cytochrome P-450 is a key marker of inhibition of colitis in mice by caffeic acid, an anti-inflammatory antioxidant compound widely. . (Science Daily)
Ticagrelor — Is There Need for a New Player in the Antiplatelet-Therapy Field? Sep 10, 2009
The two-step activation process, involving a series of cytochrome P-450 (CYP) isoenzymes, is susceptible to the interference of genetic polymorphisms2 and drug drug interactions. 3 Patients with a poor response to clopidogrel have an increased risk of coronary thrombosis. (New England Journal of Medicine)
Cytochrome P-450 Polymorphisms and Response to Clopidogrel May 21, 2009
However, no direct evidence of the causal involvement of the cytochrome P-450 enzyme CYP2C19 in the biotransformation of clopidogrel to its active metabolite is presented. To test the hypothesis of Mega et al., we incubated clopidogrel, the inactive metabolic intermediate 2-oxo-clopidogrel,2 and the known CYP2C19 substrate omeprazole3. (New England Journal of Medicine)
A 9-Month-Old Boy with Seizures Apr 9, 2009
Phenytoin accelerates metabolism of 1,25-dihydroxyvitamin D because of induction of the cytochrome P-450 system, and it will lead to exacerbation of hypocalcemia and seizures. 2,3,4 Phenytoin also is implicated in end-organ resistance to the biologic effects of 1,25-dihydroxyvitamin D.4. (New England Journal of Medicine)
