New Mechanism Identified for Beneficial Effects of Aspirin in Cardiovascular Disease Nov 20, 2009
20, 2006) A new study using ovarian cancer cell lines shows promise in treating the deadly disease by combining the chemotherapy drug cisplatin with an aspirin-like compound to make recurrent cancer cells less. . (Science Daily)
Why Certain Drug Combinations Backfire Nov 17, 2009
29, 2006) One of the most effective chemotherapy drugs against cancer is cisplatin because it attaches to cancer DNA and disrupts repair. However, it also kills healthy tissue. (Science Daily)
Drug Shrinks Lung Cancer Tumors In Mice Nov 12, 2009
11, 2009) A potential new drug for lung cancer has eliminated tumours in 50% of mice in a new study published November 10 in the journal Cancer Research. In the animals, the drug also stopped lung cancer tumours from growing and becoming resistant to treatment. (Science Daily)
Drug 'shrinks lung cancer tumour' Nov 11, 2009
" Initially, the new drug was tested on cells taken from human tumours. It stopped the cells proliferating, and neutralised their defences, allowing them to be killed off with standard chemotherapy. Follow-up tests on mice showed the drug was effective against tumour cells, both in isolation, and in combination with the standard chemotherapy agent, cisplatin. Dr Joanna Owens, of the charity Cancer Research UK, said: "It is encouraging to see potential new drugs for lung cancer in the initial... (BBC News -- Health)
Study of concurrent radiotherapy, chemotherapy shows promise in small cell lung cancer Nov 4, 2009
A previous phase III study conducted at M. D. Anderson and other sites through the North America Intergroup, showed accelerated fractionated radiotherapy (treatment in which radiation levels are increased over time) with concurrent VP-16 (etoposide) and cisplatin (platinum-based drugs) improved five-year survival rates. But this treatment often causes other side effects. (EurekAlert!)
Cisplatin versus Cisplatin plus Doxorubicin for Standard-Risk Hepatoblastoma Oct 22, 2009
After they received one cycle of cisplatin (80 mg per square meter of body-surface area per 24 hours), we randomly assigned patients to receive cisplatin (every 14 days) or cisplatin plus doxorubicin administered in three preoperative cycles and two postoperative cycles. The primary outcome was the rate of complete resection, and the trial was powered to test the noninferiority of cisplatin alone (<10% difference in the rate of complete resection) ... Results Between June 1998 and December 2006,... (New England Journal of Medicine)
Anti-angiogenesis Drugs and Mesothe... Oct 21, 2009
Research and trials using anti-angiogenesis drugs on several types of untreatable cancers have been ongoing, and Mesothelioma Web writes that "researchers are currently studying both natural and synthetic anti-angiogenesis inhibitors, and although many of these drugs are still available only in clinical trials, the first anti-angiogenesis drug, bevacizumab (Avastin), was approved by the Food and Drug Administration (in February, 2004) for use in the treatment of metastatic colon cancer. A Phase... (Suite101.com)
Metals could forge new cancer drug Oct 19, 2009
The compounds were also effective against ovarian cancer cells which are resistant to the drug Cisplatin, the most successful transition metal drug, which contains the metal platinum. Dr Patrick McGowan, one of the lead authors of the research from the School of Chemistry at the University of Leeds, explains: "Ruthenium and Osmium compounds are showing very high levels of activity against ovarian cancer, which is a significant step forward in the field of medicinal chemistry. Sabine H. van Rijt,... (EurekAlert!)
Treatment Not Testicular Cancer Poses Greatest Risk To Survivors' Long-term Health Oct 16, 2009
" Key findings from the review, which covered 40 studies published between 1990 and 2008, included: About 80 per cent of men who have one testicle removed continue to produce sperm, often at reduced levels, and although men are advised to freeze their semen before treatment, less than 10 per cent use their frozen samples later on. Pulmonary complications can arise in men who receive the drug bleomycin before larger surgical procedures, particularly if they are aged 40 or over. Radiotherapy can... (Science Daily)
DNA damage induced by cis- and carboplatin as indicator for in vitro sensitivity of ovarian carcinoma cells Oct 11, 2009
DNA damage after a one day treatment with cis- or carboplatin correlated well with the cytotoxic effects after a 7 day treatment (r = 0,942 for cisplatin r = 0. 971 for carboplatin). (BioMed Central)
New Mesothelioma Treatment Options Oct 2, 2009
The standard treatment approach for newly diagnosed mesothelioma patients is a combination of the chemotherapy drugs cisplatin or carboplatin and Altima ... Researchers are just beginning to study this drug in patients with advanced cancer, and they will attempt to learn how much of the CBP501 drug can be safely given to patients in combination with the standard chemotherapy drugs cisplatin and Altima. (Suite101.com)
Scientists Discover How Chemo Can Make Women Infertile Sep 30, 2009
Intriguingly, the scientists also found that another anti-cancer drug might counteract the negative effects of the chemotherapy drug cisplatin ... In particular, cisplatin, which was studied in this trial, causes specific types of chromosomal damage ... Cisplatin is primarily usually used to treat ovarian cancer, Attia noted. (MEDLINEplus)
OPAXIO(TM) Phase II Trial in Esophageal Cancer to be Presented in Proffered Session at the International Society of Gastrointestinal Oncology Annual Meeting Sep 24, 2009
SEATTLE, Sept. 24 /PRNewswire-FirstCall/ -- Cell Therapeutics, Inc. (CTI) (Nasdaq and MTA: CTIC) announced today that data from a Phase II study from Brown University of OPAXIO(TM) (paclitaxel poliglumex) combined with standard cisplatin and concurrent radiation in patients with advanced esophageal cancer will be presented by Dr. Howard Safran in an oral Proffered Papers session at the Annual Meeting of the International Society of Gastrointestinal Oncology in Philadelphia, Pennsylvania on... (PR Newswire)
Replication At DNA Damage Sites Highlights Fanconi Anemia And Breast Cancer Proteins Sep 12, 2009
He says DNA crosslinks are the most severe type of DNA damage; they're actually turned against cancer in certain drugs, including cisplatin. Answers have been elusive. (Science Daily)
Melanosome Dynamics And Sensitivity Of Melanoma Cells To Chemotherapy Sep 11, 2009
They also found that melanoma cells that survived cisplatin treatment had more stage II-III functional melanosomes also known as early melansomes because they have not initiated melanin synthesis than untreated melanoma cells. In addition, when melanosomes were reverted to relatively early stages, the melanoma cells became more resistant to cisplatin. (Science Daily)
Gene Assay To Help To Predict Lung Cancer Treatment Resistance Aug 28, 2009
The researchers tested docetaxel, cisplatin, gemcitabine and combinations of the agents on tumour cells taken from 49 fresh NSCLC samples. There were considerable differences between tumors in their sensitivity to individual agents and combinations, though the combination of cisplatin + gemcitabine was usually the most active. (Science Daily)
Hope for individualized lung chemotherapy Aug 27, 2009
For instance, docetaxel activity showed some dependence on the expression of drug pumps, while cisplatin activity showed some dependence on DNA repair enzyme expression. Activity of both drugs was influenced more strongly still by the expression of anti- and pro-apoptotic genes by the tumor for both docetaxel and cisplatin ... The doublet combinations of cisplatin with gemcitabine and cisplatin with docetaxel showed gene expression signatures incorporating resistance mechanisms for both agents. (BioMed Central)
Study Supports DNA Repair-blocker Research In Cancer Therapy Aug 21, 2009
To find out if this overlap might pose a problem for cdk-inhibitor therapy, the researchers disabled just one of the proteins -- cdk1 -- in cultured lung cancer cells and treated the cells with cisplatin, a DNA-damaging agent. Even though the partner cdk2 protein was still active, the cdk1-depleted cancer cells failed to stop, rest, and repair themselves; it was evident that they were now more vulnerable to death from the cisplatin ... (June 2, 2009) Researchers have now identified a way to... (Science Daily)
U.S. District Court Rules Against Lilly Regarding Gemzar Patent Aug 18, 2009
GEMZAR is indicated in combination with cisplatin (another type of chemotherapy) for the first-line treatment of patients with locally advanced (Stage IIIA or Stage IIIB) or metastatic (Stage IV or cancer that has spread) non-small cell lung cancer for whom surgery is not possible. GEMZAR in combination with paclitaxel is approved by the FDA for the first-line treatment of patients with metastatic breast cancer after they have received another type of chemotherapy called an anthracycline, unless... (PR Newswire)
Erbituxs marginal clinical benefit in lung cancer could prompt second look from regulators Aug 14, 2009
Additionally, it is not possible to administer cisplatin at the doses used in the FLEX trial, said Mencoboni ... Vinorelbine plus cisplatin is not the standard of care in the EU nor in the US, Novello said, adding that the drugs toxicity profile is important. (FT.com -- Markets)
Anti-psychotic Drugs Could Help Fight Cancer Aug 14, 2009
(June 2, 2009) Researchers have now identified a way to enhance the in vitro anticancer effects of the commonly used platinum-based drug cisplatin and hope that it might be possible to translate these data into the. (Aug. (Science Daily)
New Cancer Drug Delivery System Is Effective And Reversible Aug 11, 2009
The researchers then developed an effective method for attaching the aptamer to a liposome loaded with cisplatin, a drug that effectively kills cancer cells but has troublesome side effects when administered intravenously ... 5 percent of the breast cancer cells had died, while less than 12 percent of breast cancer cells treated with cisplatin alone had died ... "By labeling a liposome that contains cisplatin with a cancer cell-specific aptamer, we have shown delivery of the drugs to cancer... (Science Daily)
Antibody Linked To Chemotherapy Drug Inhibits Ovarian Cancer In Lab Aug 9, 2009
20, 2006) A new study using ovarian cancer cell lines shows promise in treating the deadly disease by combining the chemotherapy drug cisplatin with an aspirin-like compound to make recurrent cancer cells less. (Sep. (Science Daily)
Advanced targeted therapies effective as first-line treatment for lung cancer Aug 2, 2009
A RANDOMIZED PHASE III STUDY OF GEFITINIB VERSUS STANDARD CHEMOTHERAPY (GEMCITABINE PLUS CISPLATIN) AS A FIRST-LINE TREATMENT FOR NEVER-SMOKERS WITH ADVANCED OR METASTATIC ADENOCARCINOMA OF THE LUNG (ABSTRACT # PRS.4). Doctors are constantly on the look out for advancements to better treat and tailor cancer treatment to the individual. (EurekAlert!)
Nanoparticle-delivered 'suicide' genes slowed ovarian tumor growth Jul 30, 2009
Administration of nanoparticles to three different ovarian cancer mouse models prolonged lifespan by nearly four weeks and suppressed tumor growth more effectively, and with minimal non-specific cytotoxicity, than in mice treated with clinically relevant doses of cisplatin and paclitaxel. Edward Sausville, M.D., Ph. (EurekAlert!)
Genes Linked To Chemoresistance Identified Jul 22, 2009
Sarkar said that AEG-1 contributes to resistance to not only 5-FU, but also to other chemotherapeutics such as doxorubicin and cisplatin, although the molecular mechanism of resistance to the latter drugs is different from 5-FU. The team is currently conducting studies to further understand the molecular mechanisms by which AEG-1 induces resistance to chemotherapy so that this knowledge might be applied to develop strategies to maximize the efficacy of chemotherapeutics. Additionally, novel... (Science Daily)
New Information About DNA Repair Mechanism Could Lead To Better Cancer Drugs Jul 21, 2009
11, 2008) Scientists have identified a new mechanism that explains why some recurrent ovarian tumors become resistant to treatment with commonly used platinum-based chemotherapy drugs such as cisplatin and. . (Science Daily)
Mixed Results From Trials Of DHA In Alzheimer's Disease And Age-related Cognitive Decline Jul 17, 2009
5, 2009) Docosahexanoic acid, an omega-3 fatty acid found in fish oils, has been shown to reduce the size of tumors and enhance the positive effects of the chemotherapy drug cisplatin, while limiting its. . (Science Daily)
Erythropoietin overrides the triggering effect of DNA platination products in a mouse model of Cisplatin-induced neuropathy Jul 15, 2009
Cisplatin mediates its antineoplastic activity by formation of distinct DNA intrastrand cross links. The clinical efficacy and desirable dose escalations of cisplatin are restricted by the accumulation of DNA lesions in dorsal root ganglion (DRG) cells leading to sensory polyneuropathy (PNP) ... We investigated in a mouse model by which mechanism recombinant erythropoietin (rhEPO) protects the peripheral nervous system from structural and functional damage caused by cisplatin treatment with... (BioMed Central)
Wilmington audiologist warns against hearing loss for cancer patients Jun 30, 2009
Specifically, three chemotherapy drugs cisplatin, carboplatin, and mechlorethamine have been associated with hearing problems. In addition, other common drugs prescribed to cancer patients can impact inner ear health. (Wilmington Advocate, MA)
Voice Box Can Be Preserved, Even With The Largest Cancers, Study Suggests Jun 30, 2009
1, 2009) Patients with larynx cancer who received a three-drug combination of docetaxel, cisplatin and 5-fluorouracil during induction chemotherapy were more likely to retain larynx function than were. (May 16, 2005) Researchers from the University of Pennsylvania School of Medicine's Department of Otorhinolaryngology/Head and Neck Surgery, have completed two studies -- the most comprehensive and largest to date. (Science Daily)
Therapeutic Delivery Of A Gene To Dysfunctional Nerves Jun 27, 2009
These conditions, which are extremely painful, include shingles and can be caused by anticancer drugs such as cisplatin. In many sensory neuronopathies, the nerves that are dysfunctional are those in a region of the body known as the dorsal root ganglion (DRG), and these conditions are particularly difficult to treat. (Science Daily)
GEORGE B. KAUFFMAN: Chemical elements, then and now Jun 21, 2009
Former Bee reporter Jim Steinberg told me that treatment of his parotid gland's fourth-stage cancer with cisplatin, the world's most widely used anti-cancer drug, saved his life. The Institute for Scientific Information designated the synthesis of this platinum compound by my former Fresno State student Dwaine O. Cowan and me a "Citation Classic" -- "one of the most frequently cited works in its field.". (Fresno Bee -- Opinion)
Cancer patients should be wary Jun 17, 2009
Magnesium and thiazide (bad with cisplatin and similar cancer drugs). Red clover, dong quai, licorice (hormonal risk for women on aromatase inhibitors after breast cancer). (North County Times)
Most cancer patients seek natural remedies Jun 16, 2009
St. John's wort (lowers effectiveness of many medicines) Fish oil, garlic, ginger, gingko, feverfew (bleeding risk) Magnesium and thiazide (bad with cisplatin and similar cancer drugs) Red clover, dong quai, licorice (hormonal risk for women on aromatase inhibitors after breast cancer) Folic acid (interferes with the cancer drug methotrexate). Sources: Society for Integrative Oncology, American Dietetic Association, various federal agency Web sites, AP interviews. (MSNBC -- Health)
Enhancing The Effects Of Platinum-based Anti-cancer Drugs Jun 3, 2009
ScienceDaily (June 2, 2009) Researchers have now identified a way to enhance the in vitro anticancer effects of the commonly used platinum-based drug cisplatin and hope that it might be possible to translate these data into the development of a clinical strategy to enhance the anti-cancer effects of platinum-based drugs ... Daqing Li and colleagues, at the University of Pennsylvania School of Medicine, Philadelphia, have identified in vitro and in mice a way to enhance the anticancer effects of... (Science Daily)
Paclitaxel Poliglumex (OPAXIO(TM)) Added to Cisplatin and Radiation Produces 45% Pathologic Complete Remissions in Patients With Esophageal Cancer Jun 3, 2009
June 3 /PRNewswire-FirstCall/ -- Cell Therapeutics, Inc. ("CTI") (Nasdaq and MTA: CTIC) announced today that, in a study released from Brown University at the 2009 American Society for Clinical Oncology (ASCO) Annual Meeting, patients with cancer of the lower esophagus had evidence of a high pathological complete response ("CR") rate when given OPAXIO, a biologically enhanced paclitaxel, in addition to cisplatin and full-course radiotherapy ... Standard neoadjuvant treatment for esophageal... (PR Newswire)
Avastin Shows No Benefit Against Early Stage Colon Cancer Jun 2, 2009
Disappointing' results may yet be reversed with longer-term study, researchers say. Saturday, May 30, 2009. (MEDLINEplus)
Study Showed Lilly's GEMZAR(R) (gemcitabine HCl for injection) Improved Progression-Free Survival in Cervical Cancer Patients Jun 1, 2009
The current standard of care for women with locally advanced cervical cancer consists of the chemotherapy cisplatin and radiation (chemoradiation) ... Patients on arm A were treated with cisplatin (40 mg/m(2)) and gemcitabine (125 mg/m(2)) weekly for six doses along with concurrent external radiation (50 ... 8 Gy/day, 5 days per week), followed by brachytherapy (30-35 Gy) and then two adjuvant 21-day cycles of gemcitabine (1000 mg/m(2)) on days 1 and 8 plus cisplatin (50 mg/m(2)) on day 1. (PR Newswire)
Induction Chemotherapy Followed by ChemoRadiotherapy Increased Time-to-Treatment Failure Compared to ChemoRadiotherapy Alone in Patients With Unresectable Locally Advanced Head & Neck Cancer May 30, 2009
This study enrolled 439 patients with Locally Advanced Head and Neck Cancer with good performance status, who were randomly assigned to receive standard CRT (cisplatin and fractionated radiation) versus the same treatment preceded by IC, which consisted of cisplatin plus 5-fluorouracil (5-FU) with or without Taxotere(R) (docetaxel) Injection Concentrate. The study was designed to compare the results of those patients who received IC prior to CRT (sequential therapy) and patients who received CRT... (Canada Newswire)
Get a free hearing screening May 30 May 29, 2009
Frank Pantina, above, is a registered pharmacist and sole owner of Cross Bay Chemist, located at 158-14 Cross Bay Boulevard in Howard Beach (Queens Chronicle, NY)
Frank Pantina, above, is a registered pharmacist and sole owner of Cross Bay Chemist, located at 158-14 Cross Bay Boulevard in Howard Beach. (photo by Frank Pantina)"> May 29, 2009
Queens Chronicle - Get a free hearing screening May 30. Get a free hearing screening May 30 05/28/2009. (Queens Chronicle, NY)
Takeda to Acquire IDM Pharma, Adding MEPACT(R) (Mifamurtide), the First Treatment Approved for Osteosarcoma in More Than 20 Years, to Its Oncology Franchise May 18, 2009
The study evaluated patient outcomes with the addition of MEPACT to three- or four-drug adjuvant chemotherapy (cisplatin, doxorubicin, and methotrexate with or without ifosfamide). Results demonstrated that the addition of MEPACT to chemotherapy resulted in approximately a 30 percent decrease in the risk of death with 78 percent of patients surviving after six years of follow-up after treatment with MEPACT. MEPACT was well tolerated. (PR Newswire)
Bayer and Onyx Announce Nexavar Data Presentations at 45th American Society of Clinical Oncology Annual Meeting May 15, 2009
A Phase I Dose-Finding Study of Sorafenib in Combination with Capecitabine and Cisplatin as a First-Line Treatment in Patients with Advanced Gastric Cancer. Chul Kim, M.D., Yoon-Koo Kang, M.D., Asan Medical Center, Seoul, Republic of Korea. (PR Newswire)
Personalized therapy for Metastatic... May 14, 2009
Lung cancer patients with high expression of BRCA1 are sensitive to drugs like paclitaxel while patients with low BRCA1 are more sensitive to the cisplatin drug ... Patients with EGFR mutations received an Erlotinib chemotherapeutic treatment and those without EGFR mutations received a chemotherapeutic treatment containing or not cisplatin ... The cisplatin treatment was given based on their BRCA1 expression level. (Suite101.com)
The Recession's Impact: Closing The Clinic Apr 6, 2009
When I had cancer, the drug I was treated with - Cisplatin - had been on the market nearly 2 decades and it worked fine. It was indeed expensive - but only because it used platinum. (CBS News)
Omega-3 Kills Cancer Cells Apr 3, 2009
Docosahexanoic acid (DHA), an omega-3 fatty acid found in fish oils, has been shown to reduce the size of tumors and enhance the positive effects of the chemotherapy drug cisplatin, while limiting its harmful side effects ... Professor A. M. El-Mowafy led a team of researchers from Mansoura University, Egypt, who studied DHA's effects on solid tumors growing in mice, as well as investigating how this fatty acid interacts with cisplatin, a chemotherapy drug that is known to cause kidney damage... (Newsmax)
Fatty fish-oil may help reduce tumour Apr 2, 2009
A.M. El-Mowafy and colleagues from Mansoura University in Egypt looked at how an omega 3 fatty acid called docosahexanoic acid, or DHA, affected solid tumours growing in mice and how well it interacted with the chemotherapy drug cisplatin. "Our results suggest a new, fruitful drug regimen in the management of solid tumours based on combining cisplatin and possibly other chemotherapeutics with DHA," El-Mowafy said in a statement ... "DHA elicited prominent chemo-preventative effects on its own,... (India Times, India)
Three-drug Chemotherapy Combination Increases Organ Preservation In Patients With Larynx Cancer Apr 2, 2009
1, 2009) Patients with larynx cancer who received a three-drug combination of docetaxel, cisplatin and 5-fluorouracil (TPF) during induction chemotherapy were more likely to retain larynx function than were patients treated with cisplatin and 5-fluoruracil (PF) alone, according to data from a randomized controlled trial in the March 24 online issue of the Journal of the National Cancer Institute ... Randomized Trial of Induction Chemotherapy with Cisplatin and 5-fluorouracil with or Without... (Science Daily)
Drug Combo Helps Larynx Cancer Patients Preserve Voice Box Mar 27, 2009
Their study compared treatment with a combination of three drugs -- docetaxel, cisplatin and 5-fluoruracil (TPF) -- during induction chemotherapy, against a combination of cisplatin and 5-fluoruracil (PF). PF chemotherapy followed by radiation is commonly used as an alternative to surgery in the treatment of patients with locally advanced larynx (voice box) and hypopharynx cancer. (MEDLINEplus)
Twin Nanoparticle Shown Effective At Targeting, Killing Breast Cancer Cells Mar 15, 2009
The combination nanoparticle binds to the Her-2 tumor cell and unloads the cancer-fighting drug cisplatin directly into the infected cell ... On the other end, they attached cisplatin to the gold nanoparticle ... Once docked, the vehicle unloads its "passenger," the cisplatin, into the malignant cell. (Science Daily)
LegalView Updates Its Mesothelioma Information Portal With Information of Treatment Toxicity Level Testing Among Patients Mar 15, 2009
The study, out of Boston, is utilizing intraoperative intracavitary hyperthermic cisplatin perfusion along with amifostine, to assist in preventing cisplatin toxicity. The drug cisplatin is a common chemotherapy treatment administered to and used to treat the mesothelioma side effects. (Yahoo News -- Press Releases)
The high cost of cancer Mar 10, 2009
Although Chiappori rarely deals with treatment costs directly, he said, the standard treatment for small-cell lung cancer consists of radiation therapy and two anticancer drugs, etoposide and cisplatin, which are off patent and should be less expensive than newer, more targeted therapies. Both drugs work against the rapid cellular division that characterizes cancer cells as they whir out of control. (Florida Today)
