Postoperative Chemotherapy Does Not Improve Survival In Gastric Cancer Patients, Study Suggests Apr 1, 2008
Recent studies have suggested that a combination of cisplatin, epirubicin, 5-fluorouracil and leucovorin (PELF) improves outcome in patients with metastatic gastric cancer. To test the PELF combination in patients with localized disease, Francesco Di Costanzo, M.D., of the University Hospital Careggi in Florence, Italy, and colleagues in the Italian Oncology Group for Cancer Research conducted a randomized controlled trial in which 258 patients were treated with surgery or surgery followed by... (Science Daily)
Adherex Announces Phase III Trial With STS in Collaboration With the Children's Oncology Group Mar 26, 2008
RESEARCH TRIANGLE PARK, NORTH CAROLINA--(Marketwire - March 26, 2008) - Adherex Technologies Inc. (TSX: - ; AMEX: - ), a biopharmaceutical company devoted to solving problems for patients with cancer, announced today the activation of a Phase III trial with sodium thiosulfate (STS) to prevent hearing loss in children receiving cisplatin-based chemotherapy in collaboration with the Children's Oncology Group (COG) ... "The great progress that has been made in the curative treatments of childhood... (CCNMatthews Press Releases)
BioNumerik Pharmaceuticals and ASKA Pharmaceutical Co. Announce Results from Phase III Clinical Trial of Tavocept(TM) Mar 18, 2008
- Data provides evidence of survival increase in advanced non-small cell lung cancer patients receiving Tavocept in conjunction with paclitaxel and cisplatin - Multiple statistically significant findings include reductions in chemotherapy-induced kidney damage and vomiting SAN ANTONIO and TOKYO, March 18 /PRNewswire/ -- BioNumerik Pharmaceuticals, Inc. ("BioNumerik") and ASKA Pharmaceutical Co., Ltd. ("ASKA") today announced the results of a Phase III clinical trial of Tavocept(TM) in patients... (PR Newswire)
Sun Pharma gets US FDA nod to market generic Ethyol Mar 17, 2008
Sun Pharma's amifostine injection would be used for reduction of kidney damage in patients who have advanced ovarian cancer and are being given repeat doses of cisplatin. Ethyol is covered under three patents and this ANDA was filed against all the patents. (Hindu)
Better Regulation Of Home Genetic Tests Needed, Researchers Urge Mar 17, 2008
2, 2004) Genetic variations in an individual's ability to repair DNA damage may help predict survival in lung cancer patients treated with the common chemotherapy drugs cisplatin or carboplatin, a new. . (Science Daily)
Post-Op Chemo Fails to Boost Survival in Stomach Cancers Mar 15, 2008
However, some recent research has suggested that a chemotherapy combination of cisplatin, epirubicin, 5-fluorouracil and leucovorin (PELF) improves outcomes in people with metastatic gastric cancer. In this study, researchers tested the PELF combination in patients with localized gastric cancer. (MEDLINEplus)
Chemotherapy in Unresectable Head and Neck Cancer Mar 6, 2008
To the Editor: Radiotherapy alone in patients with advanced head and neck cancer is not the treatment of choice, even when cisplatin, fluorouracil, and docetaxel (TPF) are given. Vermorken et al. (Oct. (New England Journal of Medicine)
Thalidomide Shows Promise For Treatment Of Recurrent Ovarian Cancer, Study Suggests Mar 1, 2008
29, 2008) Thalidomide, a drug blamed in the 1950s for causing birth defects, is now showing promise as a safe and effective treatment for women with recurrent ovarian cancer, according to a study led by a University of Minnesota Cancer Center researcher. Levi Downs, Jr., M.D., principal investigator for the multicenter, randomized Phase II clinical trial, has published the findings of this research study in the current issue of the journal Cancer. (Science Daily)
Experimental Anti-cancer Drug Reduces Tumor Growth And Tumor Volume In Mice Feb 11, 2008
In the human breast cancer, Titanocene Y showed cell death induction comparable to the widely-used chemotherapy drug Cisplatin. Dr Tacke's group has been working on anti-cancer drugs belonging to the titanocene family for five years. (Science Daily)
Study reveals why certain ovarian cancers develop resistance to platinum-based chemotherapy Feb 11, 2008
Mechanism of cisplatin resistance 'unlike any previously identified. SEATTLE A team of researchers led by Fred Hutchinson Cancer Research Center has identified a new mechanism that explains why some recurrent ovarian tumors become resistant to treatment with commonly used platinum-based chemotherapy drugs such as cisplatin and carboplatin ... While these findings are based on the study of ovarian-cancer cells from women with inherited mutations in the BRCA2 gene, they also may help explain the... (EurekAlert!)
Explaining Chemotherapy-associated Nausea Feb 4, 2008
To explore whether sensory nerves traveling from the intestinal system to the brain contribute to nausea and illness associated with chemotherapy, the Monell researchers examined the incidence of pica in rats that received the potent chemotherapy drug cisplatin. Cisplatin treatment, widely used for a variety of cancers, is highly associated with nausea and vomiting ... In the Monell study, rats given cisplatin began to eat clay, decreased their food intake, and lost body weight. (Science Daily)
Protein Class Displays Strong Anticancer Action Jan 27, 2008
Our research suggests that drugs like cisplatin and novobiocin kill cells as much from this newly discovered mechanism as any other mechanism of cell death, says Solomon H. Snyder, M.D., a professor of neuroscience at Hopkins ... The team then asked whether the anticancer drugs cisplatin and novobiocin, which cause cell death, somehow interfered with HSP90-IP6K2 interactions ... But the drugs cisplatin and novobiocin can bind to HSP90 and cause it to let go of IP6K2, freeing IP6K2 to promote... (Science Daily)
Capecitabine and Oxaliplatin for Advanced Esophagogastric Cancer Jan 3, 2008
Background We evaluated capecitabine (an oral fluoropyrimidine) and oxaliplatin (a platinum compound) as alternatives to infused fluorouracil and cisplatin, respectively, for untreated advanced esophagogastric cancer. Methods In a two-by-two design, we randomly assigned 1002 patients to receive triplet therapy with epirubicin and cisplatin plus either fluorouracil (ECF) or capecitabine (ECX) or triplet therapy with epirubicin and oxaliplatin plus either fluorouracil (EOF) or capecitabine (EOX)... (New England Journal of Medicine)
Puff snuff: quit-smoking aid added to subsidised-drugs list Jan 2, 2008
About 300 patients are expected to use Alimta each year to treat mesothelioma, in combination with another drug, cisplatin. Vaxiprox junior, an influenza vaccine for children under 3 at risk of chest infections, was also added to the list, as were eye medicines that optometrists can prescribe patients after gaining approval from Medicare. (Sydney Morning Herald -- Australia)
Cancer Treatment: Light Powered Platinum 80 Times More Powerful Than Similar Cancer Treatments Dec 26, 2007
In fact it is between 13 and 80 times more toxic (depending on how and on which cells it is used) to cancer cells than the current platinum based anti-cancer drug Cisplatin. Moreover it kills the cells by a different mechanism of action, so it can also kill cisplatin-resistant cells ... 29, 2006) One of the most effective chemotherapy drugs against cancer is cisplatin because it attaches to cancer DNA and disrupts repair. (Science Daily)
Extracellular Protein Sensitizes Ovarian Cancer Cells To Chemotherapy Dec 13, 2007
20, 2006) A new study using ovarian cancer cell lines shows promise in treating the deadly disease by combining the chemotherapy drug cisplatin with an aspirin-like compound to make recurrent cancer cells less. (Jun. (Science Daily)
HEALTH NOTES / Hearing loss not all that disquieting Nov 30, 2007
Cells are also damaged by loud noises and sometimes medication such as gentamicin, an intravenous antibiotic typically used for severe infection; cisplatin, a chemotherapy agent; and some diuretic drugs, such as furosemide (Lasix). Hearing loss generally becomes noticeable after age 50 and affects approximately one-third of people over age 65. (Cohasset Mariner, MA)
New Targeted Approach To Light-activated Cancer Drugs Nov 13, 2007
29, 2006) One of the most effective chemotherapy drugs against cancer is cisplatin because it attaches to cancer DNA and disrupts repair. However, it also kills healthy tissue. (Science Daily)
How Does The Antitumor Drug Get To The Cell Nucleus? Nov 6, 2007
5, 2007) Platinum complexes such as the well-known cisplatin are powerful antitumor medications ... But how does cisplatin get to the nucleus ... It has always been assumed that cisplatin simply passes through the cell membrane; however, growing evidence indicates that a copper transporter is involved. (Science Daily)
New Treatment Option Studied For Bladder Cancer Nov 1, 2007
The unfortunate reality is that kidney problems often result from bladder cancer which precludes the usual chemotherapy package of cisplatin and gemcitabine, says Dr. Teresa A. Coleman, hematologist-oncologist at the MCG Cancer Center ... Patients with stage two disease, which has spread beyond its origin in the bladder s lining, typically get cisplatin and gemcitabine before or after surgery or in conjunction with radiation therapy ... However, a major side effect of cisplatin is kidney... (Science Daily)
Three Chemo Drugs Better Than Two for Advanced Head/Neck Cancers Oct 31, 2007
The study participants were randomly assigned to receive the standard two-drug regimen (cisplatin and fluorouracil) or the new three-drug treatment which included cisplatin, fluorouracil and docetaxel. People in both groups then received seven weeks of weekly chemoradiotherapy (chemotherapy and radiation combined) with carboplatin, and radiotherapy (radiation treatment) for five days a week. (MEDLINEplus)
Combination Targets For Cancer: Some Drugs Work Well Together, Studies Suggest Oct 30, 2007
If their findings in cell culture and animal models of CCA can be applied to humans, the combination of cisplatin, 5-fluorouracil or gemcitabine with a TRAIL-receptor antibody would be the first effective treatment for this disease, they say ... Humphreys and his colleagues experimented with combinations of cisplatin, 5-fluorouracil and gemcitabine given with or prior to treatment with the human TRAIL-receptor antibodies in cholangiocarcinoma cell cultures ... According to Humphreys, mouse... (Science Daily)
Adherex and the International Childhood Liver Tumour Strategy Group (SIOPEL) Announce the Launch of a Phase III Trial of STS Oct 30, 2007
"Cisplatin, for instance, continues to be an important treatment option in childhood cancers but can cause permanent hearing loss; such hearing loss can lead to significant long term social and behavioral issues for these children. Drugs such as STS that protect against this hearing loss, without interfering with the effectiveness of the chemotherapy, could greatly improve the quality of these children's lives." ... The multi-center, prospective randomized Phase III clinical trial is expected to... (CCNMatthews Press Releases)
Taxotere Improves Survival in Head-Neck Cancer Oct 27, 2007
In the Posner study, 48 percent of patients who received the standard regimen of cisplatin and fluorouracil as their initial treatment survived for three years, versus 62 percent of those who also received Taxotere, known generically as docetaxel ... 5 months among those who just received cisplatin and fluorouracil ... 5 percent died from side effects of the cisplatin-fluorouracil combination. (MEDLINEplus)
Improving Head and Neck Cancer Survival Oct 25, 2007
In a recent study out of Europe, researchers found a combination therapy treatment, known as TPF -- adding docetaxel to the standard PF therapy (cisplatin and fluorouracil) -- improved survival outcomes by 27 percent in patients with an unresectable cancer -- tumors that cannot be removed. What the European trial demonstrates is that TPF is a reasonable therapy for patients with an unresectable disease and promotes an improvement in survival, said Dr. Posner, the lead author of another new... (Ivanhoe)
Cisplatin and Fluorouracil Alone or with Docetaxel in Head and Neck Cancer Oct 25, 2007
Background A randomized phase 3 trial of the treatment of squamous-cell carcinoma of the head and neck compared induction chemotherapy with docetaxel plus cisplatin and fluorouracil (TPF) with cisplatin and fluorouracil (PF), followed by chemoradiotherapy ... Conclusions Patients with squamous-cell carcinoma of the head and neck who received docetaxel plus cisplatin and fluorouracil induction chemotherapy plus chemoradiotherapy had a significantly longer survival than did patients who received... (New England Journal of Medicine)
TPF Therapy in Unresectable Head and Neck Cancer Oct 25, 2007
NEJM -- Cisplatin, Fluorouracil, and Docetaxel in Unresectable Head and Neck Cancer ... Cisplatin, Fluorouracil, and Docetaxel in Unresectable Head and Neck Cancer ... Background Phase 2 studies suggest that the standard regimen of cisplatin and fluorouracil (PF) plus docetaxel (TPF) improves outcomes in squamous-cell carcinoma of the head and neck. (New England Journal of Medicine)
First New Class of Platinum-Based Chemotherapy Drug Candidates in 30 Years Demonstrate Ability to Kill Tumors Resistant to Currently Marketed Platinum Drugs Oct 24, 2007
SAN FRANCISCO, Oct. 24 /PRNewswire-FirstCall/ -- Cell Therapeutics, Inc. (CTI) (Nasdaq and MTAX: CTIC) announced preclinical data presented at the 19th annual AACR-NCI-EORTC Symposium show its bis-platinate drug candidates, CT-47613 and CT-47609, kill tumors refractory to currently marketed platinum agents carboplatin, cisplatin and oxaliplatin ... When tested in animal models of ovarian cancer and colon cancer, the bis-platinates were significantly more potent than the two most commonly used... (PR Newswire)
Mayo Clinic reports possible new therapy for patients with platinum-resistant ovarian cancer Oct 24, 2007
Thirty-three percent of study participants achieved either complete or partial tumor regression from the therapy, which combines flavopiridol and cisplatin ... In this study, the researchers evaluated a combination therapy using flavopiridol (an investigational anti-cancer agent that also boosts the effects of other therapeutics including cisplatin) with cisplatin (a platinum compound) for women with platinum-resistant ovarian or primary peritoneal (lining of the abdominal cavity) cancers ...... (EurekAlert!)
EpiCept to Present Preclinical Studies of EPC2407 in Combination With Anti-Angiogenic and Chemotherpeutic Agents at the AACR-NCI-EORTC International Conference Oct 23, 2007
(Logo: ) The preclinical studies examined the effectiveness of combining EPC2407 with an anti-angiogenesis inhibitor, Avastin(R) or Sutent(R), or with the chemotherapeutic agent cisplatin. EPC2407 was administered in combination with a cancer therapeutic agent in mouse xenograft models of human non-small cell lung carcinomas and human breast carcinomas. (PR Newswire)
Cranberry Juice May Boost Chemotherapy Oct 23, 2007
Drugs such as cisplatin and paraplatin are commonly used to treat ovarian cancer, but cancer cells tend to become resistant to them. Increasing the dosage can cause kidney failure and nerve damage. (Newsmax)
Tarceva(R) (erlotinib) Earns Approval for Lung Cancer Patients in Japan Oct 22, 2007
Results from two earlier large, randomized, placebo-controlled Phase III clinical trials in first-line advanced NSCLC patients showed no clinical benefit with concurrent administration of Tarceva with doublet platinum-based chemotherapy (carboplatin and paclitaxel or gemcitabine and cisplatin) and its use is not recommended in that setting. There have been infrequent reports of serious Interstitial Lung Disease (ILD)-like events, including fatalities, in patients receiving Tarceva for treatment... (BusinessWire)
Study finds fruit key in cancer fight Oct 17, 2007
Lupeol was found to be more effective and more potent than the conventionally used chemotherapeutic drug, cisplatin by about threefold. The experts said that, apart from using lupeol as a single agent, it could also enhance the anti-tumor activity of the chemotherapeutic drug cisplatin by 40-fold, leading to a more dramatic regression of tumors that may have established themselves. (The Standard)
Fruit compound fights some cancers Oct 17, 2007
"It can suppress the movement of cancer cells and suppress their growth and it is found to be even more effective than conventional drugs (eg. cisplatin)," said Anthony Yuen, a professor at the University of Hong Kong's surgery department. advertisement. (MSNBC -- Health)
HK experts reveals lupeol in fruits helps combat cancer Oct 17, 2007
Interestingly, lupeol was found to be more effective and more potent than conventionally used chemotherapeutic drug, cisplatin, by approximately three-fold in terms of tumor volume and degree of metastasis suppression. Besides, when lupeol was used in combination with cisplatin, the anti-tumour activity of the chemotherapeutic drug could be enhanced by 40-fold. (Xinhuanet, China)
EpiCept Announces Successful Completion of Enrollment for Phase I Trial of EPC2407 Oct 8, 2007
"We are now in the process of meeting with our advisors to move forward with a Phase Ib combination trial for the drug with other chemotherapeutic agents. Preclinical data in mouse xenograft models indicate there is either additive or synergistic activity when EPC2407 is used in combination with other cancer therapeutic agents including Cisplatin, Sutent(R)* and Avastin(R)*. We anticipate being able to initiate this combination trial in early 2008." In addition to determining the maximum... (PR Newswire)
Why Do Certain Cancers Become Resistant To Drugs? Oct 6, 2007
A pair of researchers at the University of Missouri-Columbia is working steadfastly to learn why some tumors eventually build a tolerance to the common chemotherapy drug cisplatin, in hopes of identifying the particular genes that can be manipulated to make treatment as effective as possible. In a paper published in the latest edition of Proceedings of the National Academy of Sciences (PNAS), Hannah and Stephen Alexander, professors of biological sciences in MU's College of Arts and Science, in... (Science Daily)
Gene Tests Match Up Lung Tumors, Best Treatment Oct 4, 2007
In the first part of the study, Hsu's team found that certain genes expressed in non-small cell lung cancer (NSCLC) tumors known to be sensitive to cisplatin (the most commonly-used agent in the treatment of lung cancer) were not expressed in tumors known to be resistant to cisplatin. They also found that genes expressed in the tumors resistant to cisplatin were expressed in tumors sensitive to it ... "We found the strongest inverse correlation between tumors that were sensitive to cisplatin and... (Health-Finder)
Cancer drug Taxotere given the green light to treat head and neck ... Oct 3, 2007
The Food and Drug Administration (FDA) in the United States says Taxotere can now be used in combination with cisplatin and 5-fluorouracil before the start of chemotherapy and prior to surgery ... The trial found that when Taxotere was given in conjunction with cisplatin and 5-fluorouracil, the risk of death in cancer patients was reduced by 30 percent compared to patients receiving just cisplatin and 5-fluorouracil. (News-Medical.net)
FDA approves Sanofi's Taxotere for head and neck cancer Oct 3, 2007
The US health watchdog approved French pharmaceutical firms chemotherapy agent Taxotere (docetaxel), in combination with Platinol (cisplatin) and 5-fluorouracil as induction therapy for locally advanced squamous cell carcinoma of the head and neck (SCCHN) before patients undergo chemo-radiotherapy and surgery ... The overall survival in patients who received Taxotere-based therapy was significantly improved compared to those treated with just cisplatin and 5-fluorouracil ... Cancer patients... (The Money Times)
Taxotere Gets FDA Approval For Advance Head And Neck Cancer Before ... Oct 2, 2007
The US Food and Drug Administration (FDA) has approved Taxotere Injection Concentrate combined with cisplatin and 5-fluorouracil for induction therapy of locally advance squamous cell carcinoma of the head and neck before chemoradiotherapy and surgery ... Of 251 patients who received Taxotere based therapy (TPF), overall survival was substantially improved, compared to the 243 patients who just received cisplatin and 5-fluorouracil (PF) ... They were treated every 3 weeks for 3 cycles with... (Medical News Today)
Genomic profiling of lung tumors helps doctors choose most effective treatment Sep 28, 2007
Researchers looked at the sensitivity of multiple cancerous cell lines to cisplatin, the most commonly used agent in the treatment of lung cancer. After determining which cell lines were responsive to cisplatin they looked at the RNA of these tumors and generated a genomic signature -- a pattern of gene expression particular to each individual sample ... They were able to draw conclusions about which genes were turned on and which were turned off in these samples, and subsequently created a... (EurekAlert!)
Breast Cancer Susceptibility Gene Predicts Outcome And Response To Treatment In Lung Cancer Sep 27, 2007
In addition, Dr Rosell, who is chief of the Medical Oncology Service and scientific director of oncology research at the Catalan Institute of Oncology in Barcelona, Spain, said that earlier studies in breast cancer and a study by him and his colleagues in NSCLC had linked low levels of BRCA1 expression with high sensitivity to cisplatin-based chemotherapies, while high levels of BRCA1 expression were linked with lack of response to cisplatin, but an increased sensitivity to antimicrotubule... (Science Daily)
New Chemotherapy Regimen Prolongs Survival In Difficult-to-treat Childhood Brainstem Gliomas Sep 27, 2007
However, a team of Spanish researchers have found that a chemotherapy regimen of irinotecan and cisplatin (I/C) produced rapid clinical responses and shrank the tumours by more than 20 percent in all six children enrolled in a clinical trial ... Dr Mora, who is head of the department of paediatric oncology at Hospital Sant Joan de Deu, Barcelona, Spain, explained: "The main treatment for BSGs is radiotherapy. Surgery is not really an option because of the way the tumour is situated in... (Science Daily)
A new therapy for highly effective tumor eradication using HVJ-E combined with chemotherapy Sep 21, 2007
We attempted to eradicate tumors derived from mouse colon cancer cells, CT26, by combining bleomycin (BLM)-incorporated HVJ-E (HVJ-E/BLM) with cisplatin (CDDP) administration. Methods. (BioMed Central)
ERBITUX(R) Meets Primary Endpoint of Increasing Survival in Phase III Lung Cancer Study Sep 11, 2007
NEW YORK, Sept. 11 /PRNewswire-FirstCall/ -- ImClone Systems Incorporated (Nasdaq: ) and Bristol-Myers Squibb Company (NYSE: ) today announced that a Phase III study of ERBITUX(R) (Cetuximab) in combination with platinum-based chemotherapy (vinorelbine plus cisplatin) met its primary endpoint of increasing overall survival compared with chemotherapy alone in patients with advanced non-small cell lung cancer (NSCLC). This large, randomized multi-national study, known as FLEX (First-Line Treatment... (PR Newswire)
Enzyme alerts cell's powerful army to repair DNA damage Sep 6, 2007
Cisplatin, a drug used to treat testicular and ovarian cancer, acts by stopping transcription and causing cells to die. Some other chemotherapy drugs block transcription too. (EurekAlert!)
OUR OPINION: State board makes right call on Senate proposal Aug 27, 2007
Ejvorxen wrote on Aug 25, 2007 5:31 PM:" More of even though contact is cilastatin measures severity cilazapril automobile. True et to say but with to offer emotion. Host and masks spirators cilostazol must remain eradicated. Most estimates greatest net ciloxan outcomes were occasions. The new positive impacts cimetidine our estimates blinks. It permits in liability cimex had to strain on types. For this of tort cinnarizine in motor filter efficiency mammograms. Geisinger was detected by in ing... (Demopolis Times, AL)
Cancer Cells Weakened By Cranberry Juice Aug 23, 2007
Chemotherapy using platinum drugs, including cisplatin and paraplatin, is a mainstay treatment for ovarian cancer. However, cancer cells tend to develop resistance to them, and higher doses of the drugs can cause nerve damage and kidney failure. (Click2Houston, TX)
Cranberry Could Juice Up Ovarian Cancer Treatment Aug 22, 2007
Chemotherapy treatment commonly centers on so-called "platinum drugs", such as cisplatin and paraplatin. However, many women develop therapeutic resistance, necessitating the use of ever-higher doses that in turn raise the risk for both nerve damage and kidney failure. (Health-Finder)
Phenoxodiol protects against Cisplatin induced neurite toxicity in a PC-12 cell model Aug 1, 2007
Many commonly used chemotherapeutic agents, such as Cisplatin, are restricted in their potential anti-neoplastic effectiveness by their side effects, with one of the most problematic being induction of peripheral neuropathy ... In this study we examined whether phenoxodiol could protect against Cisplatin induced neurite inhibition in PC12 cells as an indication of the potential to protect against neuropathy ... Using the PC12 neuronal cell line, concentrations of Cisplatin were chosen that... (BioMed Central)
Advanced Therapy Offers Cure For Relapsed Cancer Patient Jul 27, 2007
About 90 percent of testicular cancer patients respond to traditional therapy, which involves multiple courses of cisplatin, first used successfully in the treatment of this disease by Lawrence Einhorn, M.D., at Indiana University Cancer Center in the early 1980s. That course of therapy turned a disease from a mostly fatal cancer into one of the more curable forms of cancer for men, who typically are in their 20s when diagnosed with testicular cancer. (Science Daily)
Repeat, High Dose Chemo Can Cure Testicular Cancer Jul 27, 2007
According to Abonour, Einhorn led the way in establishing the value of drugs such as cisplatin in the treatment of testicular cancer decades ago and has worked steadily at expanding their use and value. From 7,000 to 8,000 cases of the cancer are reported in the United States each year. (MEDLINEplus)
Salvage Therapy for Metastatic Germ-Cell Tumors Jul 26, 2007
Methods We conducted a retrospective review of 184 consecutive patients with metastatic testicular cancer that had progressed after they received cisplatin-containing combination chemotherapy ... In 110 patients, cytoreduction with one or two courses of vinblastine plus ifosfamide plus cisplatin preceded the high-dose chemotherapy. (New England Journal of Medicine)
New algorithm matches any tumor cells to best possible anti-cancer treatments Jul 24, 2007
In fact, they found that their coexpression extrapolation (COXEN) system could be used to accurately predict drug sensitivity for bladder cancer cell lines to two common chemotherapies, cisplatin and paclitaxel. Even though this NCI cell set wasnt an exhaustive encyclopedia of cancer cells, we found we could use the available data to draw conclusions about other cell types we were exploring. (EurekAlert!)
Gene Screening and Paclitaxel Jul 19, 2007
Examples of effective therapeutic combinations include doxorubicin, bleomycin, vinblastine, and dacarbazine for Hodgkin's lymphoma and bleomycin, etoposide, and cisplatin for testicular cancer. Most combinations seldom cure disease, however, and their identification. (New England Journal of Medicine)
Bak Protein Sets Stressed Cells On Suicide Path, Researchers Show Jul 18, 2007
To stress cells, they blocked oxygen supplies and used the common chemotherapeutic agent cisplatin, then documented that filamentous mitochondria became fragmented very early and quickly in apoptosis. Ironically they also found the deadly fragmentation results from Bak's interaction with mitochondria-shaping proteins called mitofusins, which help mitochondria keep their filamentous shape in non-stressed cells. (Science Daily)
Nodal status is best predictor of outcome after neoadjuvant therapy for esophageal cancer Jul 14, 2007
The patients were given a standard protocol of radiation therapy and concurrent chemotherapy with fluorouracil and cisplatin before undergoing thoracotomy with lympadenoctomy and nodal dissection; the extent of surgery and lymph node dissection depended on the exact location of the tumour. 30 patients did not proceed to surgery because of disease progression or deterioration in performance status. (EurekAlert!)
New 'Longboat Delivery System' Could Mean More Potent Anti-cancer Drugs Jul 6, 2007
These include analogues of the widely used and extremely potent drugs cisplatin, carboplatin, and oxaliplatin. The report is scheduled for the July 11 issue of the Journal of the American Chemical Society, a weekly publication. (Science Daily)
EpiCept Accelerates Development of EPC2407 for Cancer Jul 3, 2007
Murine models of human tumor xenografts demonstrated EPC2407 inhibits growth of established tumors of a number of different cancer types more effectively than the other VDAs tested and was synergistic when used in combination with anticancer agents, such as Cisplatin. The combination of EPC2407 with other anticancer agents in a Phase 1b trial is planned to follow the current monotherapy trial. (PR Newswire)
On the Move: Northern Rock, Gaz de France, Prosieben Jun 29, 2007
Taxotere granted FDA priority review - the company says that the FDA has assigned priority review status to the supplemental new drug application for Taxotere Injection Concentrate in combination with cisplatin and fluorouracil for the induction therapy of patients with locally advanced squamous cell carcinoma of the head and neck prior to chemoradiotherapy and surgery. Germany. (MSNBC -- Business)
Cisplatin Is More Effective Than Carboplatin For Treating Nonsmall Cell Lung Cancer Jun 6, 2007
Some patients with advanced non--small-cell lung cancer (NSCLC) have slightly higher survival rates when treated with the chemotherapy drug cisplatin than another platinum-based drug, carboplatin, according to a study in the June 6 Journal of the National Cancer Institute. The authors conclude that cisplatin chemotherapy should remain the standard of care for these patients ... Most clinicians in North America prefer carboplatin to cisplatin because it has fewer side effects and is easier to... (Science Daily)
New Study Shows Doxorubicin Plus Paclitaxel Followed by Weekly Paclitaxel as Adjuvant Therapy for High Risk Breast Cancer Warranted in Place of Doxorubicin Plus Cyclophosphamide Followed by Paclitaxel Jun 5, 2007
D.: Phase II study of eribulin mesylate (E7389) halichondrin b analog in patients with refractory breast cancer -- Alexander Spira, M.D.: Phase II study of eribulin mesylate (E7389), a mechanistically novel inhibitor of microtubule dynamics, in patients with advanced Non-Small Cell-Lung Cancer (NSCLC) -- John Pippen, Jr., M.D., F.A.C.P.: "A Historical Overview of the Treatment of Prostate Cancer and the Evolution of Bone Marrow Transplantation" -- Marcus Neubauer, M.D., Co-Chair: Lung Cancer... (PR Newswire)
Poniard Pharmaceuticals Announces Results of Picoplatin Phase 2 Trial That Confirm and Extend Survival Benefit in Small Cell Lung Cancer Jun 4, 2007
The SPEAR (Study of Picoplatin Efficacy After Relapse) trial is enrolling patients who are refractory to, or who have progressed within six months of completing, treatment with first-line platinum-containing chemotherapy (cisplatin or carboplatin) ... Phase 2 Study Design and Findings The open-label, multi-center Phase 2 trial was designed to confirm the clinical activity of picoplatin as second-line therapy in patients with platinum-refractory disease or platinum-resistant or platinum-sensitive... (PR Newswire)
VELCADE(R) (Bortezomib) for Injection Based Therapy Substantially Improves Event-Free Survival and Complete Response Rate in Newly Diagnosed Multiple Myeloma Patients Jun 4, 2007
Patients received two cycles of a combination called VTD-PACE (VELCADE, thalidomide, dexamethasone, cisplatin, adriamycin, cyclophosphamide and etoposide) as induction therapy prior to and as consolidation therapy following stem cell transplantation. Patients were then given a combination of VTD (VELCADE, thalidomide and dexamethasone) once monthly for one year and a combination of TD (thalidomide and dexamethasone) once monthly for two additional years. (PR Newswire)
