A flexible whole-genome microarray for transcriptomics in three-spine stickleback (Gasterosteus aculeatus) Sep 11, 2009
As expected, the highest proportions of functional categories belonged to those associated with metabolic functions: metabolic process, binding, catabolism, and organelles. Conclusions. (BioMed Central)
Cytokine-dependent and -independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling May 30, 2009
This approach revealed the induction of metabolic and signaling pathways involved in cell proliferation, amino acid catabolism and response to wounding as a common themes in T. cruzi-infected cells. In addition, the downregulation of genes involved in mitotic cell cycle and cell division predicted that T. cruzi infection may impede host cell cycle progression. (BioMed Central)
The cell nuclei of skeletal muscle cells are transcriptionally active in hibernating edible dormice Mar 15, 2009
These two factors would prevent muscle atrophy usually occurring in mammals after prolonged starvation and/or inactivity as a consequence of prevailing catabolism. Understanding the mechanisms responsible for skeletal muscle preservation in hibernators could pave the way to prevention and treatment of muscle wasting associated with pathological conditions or ageing as well as life in extreme environments, such as ocean deeps or spaceflights. (BioMed Central)
Tools for more accurate dosage of drugs against HIV/AIDS and malaria Mar 7, 2009
Further work involved using a model to describe how the catabolism of the anti-malarial drug artemisinin increases and the concentration of the drug decreases when patients take this drug. When artemisinin was given to 97 patients in Vietnam without other drugs, approximately 37% of them were affected by recrudescent malaria. (EurekAlert!)
