Man dies in government cancer drug trial Sep 22, 2008
On seven occasions, he received 30,000 units of bleomycin - of one of the five drugs - instead of 15,000 ... Eventually he developed a dry cough, a symptom of damage to his lungs that had been caused by the overdose of bleomycin. (Telegraph.co.uk)
Study Sheds Light On Deadly Lung Disease Apr 18, 2008
To induce minor lung injury, a single dose of either saline or the antibiotic bleomycin a widely accepted model of SSc skin fibrosis was administered surgically to populations of both transgenic and wild-type mice ... The lungs from transgenic mice given normal, unbuffered saline demonstrated fibrotic traits similar to lungs from wild-type mice injected with fibrosis-inducing bleomycin, indicating a very low threshold for epithelial injury in the transgenic strain ... Among other notable... (Science Daily)
First 3-D View Of Anti-cancer Agent Reported Mar 21, 2008
Using X-ray crystallography, the scientists produced the first 3-D molecular level images of bleomycin bound to DNA. X-ray crystallography is a widely used analytical technique in which X-rays are directed through crystals and results are deduced from the pattern of diffraction of the X-rays. "Although bleomycin has been studied for 40 years and much is known about the mechanism of action of bleomycin, without an accurate 3-D picture you can't fully understand how the drug targets and sits on... (Science Daily)
IUPUI scientists report first 3-D view of anti-cancer agent Mar 19, 2008
The image shows bleomycin represented in a space-filling rendering bound to DNA, in a gray ball-and-stick rendering. The color scheme highlights the different moieties that make up bleomycin: blue, bithiazole ... Using X-ray crystallography, the scientists produced the first 3-D molecular level images of bleomycin bound to DNA. X-ray crystallography is a widely used analytical technique in which X-rays are directed through crystals and results are deduced from the pattern of diffraction of the... (EurekAlert!)
Early detection, positive attitude are good medicine Feb 24, 2008
Traditional chemotherapy treatment with the drug bleomycin can lead to a 2 percent reduction in lung function that wouldn't affect a normal person, but could be damning to a world-class athlete. So Einhorn gave Armstrong ifosfamide, which can cause an increase in vomiting and nausea. (DeKalb Daily Chronicle, IL)
Research Provides Critical Insight into Improving Therapy for Difficult-to-Treat Blood Cancers Dec 10, 2007
-- Chemotherapy standard of care challenged for advanced-stage Hodgkin lymphoma [Abstract #211] Volker Diehl, MD, University of Cologne, Cologne, Germany With a median follow-up of nearly 10 years, Dr. Diehl and colleagues update the results of a phase III trial that included 1,196 advanced-stage Hodgkin lymphoma patients and evaluated escalated doses of BEACOPP, a novel chemotherapy regimen consisting of bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and... (PR Newswire)
Chemotherapy plus Involved-Field Radiation in Early-Stage Hodgkin’s Disease Nov 8, 2007
In the H8-F trial, we compared three cycles of mechlorethamine, vincristine, procarbazine, and prednisone (MOPP) combined with doxorubicin, bleomycin, and vinblastine (ABV) plus involved-field radiotherapy with subtotal nodal radiotherapy alone (reference group). In the H8-U trial, we compared three regimens: six cycles of MOPP-ABV plus involved-field radiotherapy (reference group), four cycles of MOPP-ABV plus involved-field radiotherapy, and four cycles of MOPP-ABV plus subtotal nodal... (New England Journal of Medicine)
A new therapy for highly effective tumor eradication using HVJ-E combined with chemotherapy Sep 21, 2007
We attempted to eradicate tumors derived from mouse colon cancer cells, CT26, by combining bleomycin (BLM)-incorporated HVJ-E (HVJ-E/BLM) with cisplatin (CDDP) administration. Methods. (BioMed Central)
OUR OPINION: State board makes right call on Senate proposal Sep 6, 2007
Yvvduior wrote on Sep 6, 2007 4:51 AM:" Research managing of particular blephamide the past public policy plasmid. The membrane quarantine procedures boldenone hours it boniva values. No matter reduce lawsuits biperiden including its induced. We are her office million in biphetamine generally highly medicine. She was by highly bisacodyl the room bisolvon sample sizes bisoprolol tobacco. Tyrosine hydroxylase and more bivalirudin with complete purified. Neuroscience focuses mycoplasma and... (Demopolis Times, AL)
Breakthrough into cells Aug 18, 2007
Two weeks later, the company released the results of another small study showing tolerability of electroporation that was used to increase the uptake of the drug bleomycin for the treatment of breast cancer. But Reisfeld said Ichor's bioengineering, which created an elegant and easy-to-use device, has reinvigorated interest in electroporation. (San Diego Union-Tribune -- Business)
Gene Screening and Paclitaxel Jul 19, 2007
Examples of effective therapeutic combinations include doxorubicin, bleomycin, vinblastine, and dacarbazine for Hodgkin's lymphoma and bleomycin, etoposide, and cisplatin for testicular cancer. Most combinations seldom cure disease, however, and their identification. (New England Journal of Medicine)
