Eurand Enters Agreement With Daewoong Pharmaceutical Co. Ltd (South Korea) for Once-Daily Extended Release Muscle Relaxant Aug 1, 2008
The Company has partnered with several leading global pharmaceutical companies licensing its four primary technology platforms: Customized Drug Release, Bioavailability Enhancement, Taste Masking and ODTs, and Drug Conjugation ... Eurand's technology platforms include bioavailability enhancement of poorly soluble drugs, customized release, taste-masking/fast-dissolving formulations and drug conjugation. (Primezone Releases)
Merrion Pharmaceuticals plc Announces Commencement of Next Stage of Oral Drug Research Collaboration Programme With Novo Nordisk Jul 18, 2008
Merrion's patented drug delivery technologies increase bioavailability, by improving absorption in the gastrointestinal tract, of drugs that are otherwise poorly absorbed. This can provide substantial benefit in patient convenience and safety, and might also provide enhanced drug efficacy. (Primezone Releases)
Eurand Announces Conference Call On Second Quarter 2008 Financial Results Jul 18, 2008
Eurand's technology platforms include bioavailability enhancement of poorly soluble drugs, customized release, taste-masking/fast-dissolving formulations and drug conjugation. Eurand is a global company with facilities in the USA and Europe. (Primezone Releases)
Raptor Pharmaceuticals Enters Collaboration Agreement with UC San Diego in Liver Disease Jul 16, 2008
The University's clinical researchers have specific expertise in treating NASH patients, and have also worked extensively with Cysteamine. We are fortunate to work with this team to investigate our drug candidate's potential in this widespread liver disease. (Canada Newswire)
Artificial turf target of legal action Jun 25, 2008
"It's encapsulated to reduce any aspect of bioavailability." Bioavailability refers to the ability of a substance, like lead, to become biologically active when it's ingested, absorbed or inhaled. Health experts take seriously the health effects of lead exposure, particularly in children. (San Jose Mercury News)
New technology may prevent vitamin B12 deficient seniors and vegetarians from needing injections Jun 18, 2008
Currently, physicians rely on B12 shots for people with vitamin B12 deficiency because of the poor bioavailability of oral formulations. Past studies have shown that only approximately one percent of a vitamin B12 tablet gets absorbed in the bloodstream after traveling through the digestive track. (EurekAlert!)
TetraQ and Q-Pharm form strategic alliance Jun 17, 2008
A component of TetraQ's services includes bioanalytical services supporting clinical studies (including bioavailability/ bioequivalence and drug-drug interaction studies). Q-Pharm is a Phase 1 clinical trial provider, servicing the early phase trial requirements of the pharmaceutical and biotech industries in Australia and around the world. (EurekAlert! -- Business News)
No brain action for benfotiamine Jun 13, 2008
Lipid-soluble thiamine precursors have a much higher bioavailability than genuine thiamine and therefore are more suitable for therapeutic purposes. Benfotiamine (S-benzoylthiamine O-monophosphate), an amphiphilic S-acyl thiamine derivative, prevents the progression of diabetic complications, probably by increasing tissue levels of thiamine diphosphate and so enhancing transketolase activity. (BioMed Central)
Resveratrol: Thousands of Bottles of Wine, High-Dose Pills Not Required; Mega-doses May Induce Side Effects Jun 4, 2008
Longevinex' applied-for-patent (file # United States Patent Office 20050158376, filed Oct. 25, 2004) describes a nutraceutical matrix designed to enhance the absorption, bioavailability, and molecular stability of resveratrol in a manner similar to a proprietary resveratrol drug now undergoing human clinical investigation. For more information about Longevinex(R) visit. (PR Newswire)
'CURRENT BIOLOGY' STUDY: Sexual signal exaggeration affects physiological state in male barn swallows Jun 4, 2008
Testosterone increases bioavailability of carotenoids: Insights into the honesty of sexual signaling. Proc. (USA Today -- Tech)
XanGo Introduces 3SIXTY5 Whole Food Nutrition Multi-Vitamin May 31, 2008
"Our chelated approach with whole food is designed to ensure greater bioavailability - so you can better receive the benefits of a full spectrum of vitamins, minerals and essential fatty acids," he said. Each serving of 3SIXTY5 contains four layers of health protection. (Yahoo News -- Press Releases)
Arpida Enrols First Patients in "Intravenous-to-Oral" Switch Trial With Oral Iclaprim May 27, 2008
Dr Paul Hadvary, Head of Development of Arpida Ltd., commented: "Among the hospital anti-MRSA drugs that are currently in filing or late-stage development, only iclaprim shows oral bioavailability allowing clinical development and consequently offers the potential for intravenous-to-oral switch therapy. We consider the oral switch therapy to be an important option addressing an increasing therapeutic need. It allows patients to be sent home earlier, thereby increasing patient comfort, reducing... (PR Newswire)
Infinity Highlights Promising Preclinical Hedgehog Data and Announces First Quarter Financial Results May 5, 2008
As presented at AACR, preclinical studies evaluating IPI-926 in a novel mouse model of medulloblastoma demonstrated that the compound has excellent pharmaceutical properties in vivo, including oral bioavailability, potent inhibition of the Hedgehog pathway, long plasma and tumor half-life, and dose-dependent inhibition of tumor growth. Once-daily dose administration of IPI-926 in this model resulted in 100 percent survival while on treatment, and median overall survival of 48 days, or a... (Primezone Releases)
Apples may prevent hardening of arteries May 5, 2008
Kelly Decorde of the University of Montpelier in France, part of the European research team, said processing the fruit into juice has the potential to increase the bioavailability of the naturally-occurring compounds and anti-oxidants found in the whole fruit. The study, published in Molecular Nutrition and Food Research, said aortic plaque was evaluated to determine the effectiveness in decreasing plaque that is associated with atherosclerosis -- or "hardening" of the arteries caused by... (United Press International)
Apples, apple juice shown to prevent early atherosclerosis May 3, 2008
The researchers also observed that processing the fruit into juice has the potential to increase the bioavailability of the naturally-occurring compounds and antioxidants found in the whole fruit. Using a variety of established analytical techniques, aortic plaque was evaluated to determine the effectiveness in decreasing plaque that is associated with atherosclerosis. (EurekAlert!)
Researchers work to enhance nutritional value of foods Apr 20, 2008
At Ithaca, N.Y., ARS scientists are working with the Gates Foundation and the U.S. Agency for International Development to improve the iron content and bioavailability of maize, a staple crop for many African nations. GO FISH. (Yuma Daily Sun, AZ)
Synthetic Turf Council Offers Clarity & Context to Concerns About New Jersey Fields Apr 16, 2008
Lead chromate is a highly insoluble compound with extremely low bioavailability, which is diluted, extruded with resins and microencapsulated within the nylon fiber ... Extremely low bioavailability means that even if the compound were to be ingested, it is very difficult for the compound to be absorbed within the body ... The EPA soil safety standard does not take into consideration the extremely low bioavailability of compounds that are bound and encapsulated in plastics such as synthetic... (PR Newswire)
Tests find lead in artificial turf Apr 15, 2008
That testing, called bioavailability testing, will seek to determine if lead contained in the field's fibers is absorbed or rejected by the human body. CONTINUED 1. (NJ.com -- Times)
Poniard Pharmaceuticals' Oral Picoplatin Demonstrates Positive Bioavailability in Ongoing Phase 1 Trial Apr 14, 2008
and SAN DIEGO, April 13 /PRNewswire-FirstCall/ -- Poniard Pharmaceuticals, Inc. (Nasdaq: ), a biopharmaceutical company focused on oncology, today announced that an analysis of data from its ongoing Phase 1 clinical trial of an oral formulation of picoplatin in patients with solid tumors showed that picoplatin can achieve oral bioavailability of up to 44 percent in doses tested to date. These data are consistent with findings from preclinical oral bioavailability studies of picoplatin ... The... (PR Newswire)
Sludge Tested As Lead-Poisoning Fix Causes Stir Apr 14, 2008
Another study investigating whether sludge might inhibit the "bioavailability" of lead the rate it enters the bloodstream and circulates to organs and tissues was conducted on a vacant lot in East St. Louis next to an elementary school, all of whose 300 students were black and almost entirely from low-income families. In a newsletter, the EPA-funded Community Environmental Resource Program assured local residents it was all safe. (Fox News)
Multiple Presentations On Oncology Pipeline At the 2008 American Association for Cancer Research Annual Meeting Apr 14, 2008
Poster 1447 (Plasma pharmacokinetics, oral bioavailability, and interspecies scaling of the hypoxically activated prodrug, TH-302, in mice, rats, dogs and monkeys) demonstrated that TH-302 exhibits linear pharmacokinetics, excellent oral bioavailability and high clearance. We are extremely encouraged by the preclinical results we have seen with TH-302,'' said Charles Hart, Ph. (Primezone Releases)
Threshold Pharmaceuticals Announces Multiple Presentations On Oncology Pipeline At the 2008 American Association for Cancer Research Annual Meeting Apr 11, 2008
Poster 1447: Plasma pharmacokinetics, oral bioavailability, and interspecies scaling of the hypoxically activated prodrug, TH-302, in mice, rats, dogs and monkeys. The following presentation will take place on Monday, April 14 from 1:00pm to 5:00pm. (Primezone Releases)
Manufactured Buckyballs don't harm microbes that clean the environment Apr 9, 2008
Water solubility usually is directly related to the extent and rate at which cells could absorb a substance, called bioavailability, which is an important factor in a chemical's toxicity ... "Probably a lot of that is due to lack of bioavailability.". (EurekAlert!)
New Data On Infinity's Lead Anti-Cancer Candidates to be Presented At AACR Apr 7, 2008
When systemically administered in multiple preclinical animal models, IPI-926 has shown potent and selective inhibition of the Hedgehog pathway, anti-tumor activity, and attractive pharmacologic properties including oral bioavailability and extended half-life. About Infinity Pharmaceuticals, Inc.. (Primezone Releases)
Association of dopaminergic pathway gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetes Mar 23, 2008
Therefore, various genes involved in regulation of dopamine bioavailability could play a role in diabetic chronic renal insufficiency (CRI). We investigated the contribution of 12 polymorphisms from five Dopaminergic pathway genes to CRI among type-2 diabetic Asian Indian subjects. (BioMed Central)
Cytopia Nominates JAK2 Clinical Candidate for Myeloproliferative Disorders Mar 18, 2008
It also has excellent pharmacokinetics including oral bioavailability and in preclinical models has a promising safety profile. CYT387 has also recently shown efficacy in a well-validated in-vivo model of myeloproliferative disorders in studies in the laboratory of physician- scientist Michael Deininger MD PhD at Oregon Health ce University Cancer Institute, USA. Results showed a profound effects on abnormal blood counts and clinical symptoms of MPDs in mice that were dosed orally. (PR Newswire)
Baxter Presents Latest Clinical Trial Results of GAMMAGARD LIQUID Administered Subcutaneously Mar 17, 2008
The average bioavailability of the subcutaneously administered combination of GAMMAGARD LIQUID with Enhanze Technology was 92 percent of the traditional, monthly intravenous administration ... The trial also evaluated the effect of rHuPH20 on the bioavailability of GAMMAGARD LIQUID administered subcutaneously compared to intravenously ... The Phase III trial will evaluate the bioavailability of GAMMAGARD LIQUID after administration intravenously, subcutaneously or subcutaneously at an adapted... (PR Newswire)
Emisphere Technologies, Inc. Announces Conference Call for 2007 Fourth Quarter and Year End Financial Results Mar 15, 2008
Such molecules or compounds usually cannot be delivered by the oral route of administration or the benefits of these compounds are limited due to poor bioavailability, slow on-set of action or variable absorption. The eligen(R) Technology can be applied to the oral route of administration as well other delivery pathways, such as buccal, per rectum, pulmonary, intra-vaginal or transdermal. (PR Newswire)
Warnex Offers New Prostate Cancer Screening Service Mar 5, 2008
Warnex's bioanalytical services division specializes in bioequivalence and bioavailability studies for clinical trials. Warnex's medical laboratories division focuses on genetic and biochemical testing for the healthcare industry and has extensive expertise in genetic testing for human identification, molecular diagnostics, and pharmacogenetics. (CCNMatthews Press Releases)
Antihypertensive Effects of Dietary Factors Reinforced Feb 24, 2008
Personalize Your Medical News. PUTTING BREAKING MEDICAL NEWS INTO PRACTICE Sunday, February 24, 2008. (MedPage Today)
NexGenix Pharmaceuticals Presents Data on a Novel Small Molecule Inhibitor of Heat Shock Protein 90 (Hsp90) at the GTCbio Cancer Drugs Research & Development Conference Feb 23, 2008
"A number of analogs with activity similar to or better than NXD30001 have been synthesized and are being evaluated for oral bioavailability, tolerability, and efficacy," stated Allan Rubenstein, MD, CEO of NexGenix. "Our intent is to progress an i.v. formulation of NXD30001 into IND-enabling studies for breast cancer, and to develop an oral formulation from the series for neural tumors, such as those found in Neurofibromatosis Type 2, and for neurodegenerative disorders." About NexGenix... (PR Newswire)
Science Sinks Its Teeth Into 2500 Year-old Drug Problem Jan 19, 2008
Better bioavailability ... But passing the drug through the buccal (cheek) tissue also means much greater bioavailability ... Bioavailability refers to the body s capacity to absorb a substance. (Science Daily)
Heavy Metal Slips Down UK Air Quality Charts Jan 16, 2008
21, 2006) One of the most common bacteria in the Earth, Shewanella oneidensis MR-1, influences the mobility and bioavailability of iron and environmental contaminants like lead, cobalt and arsenic. (Feb. (Science Daily)
New Cranberry Hybrid High In Antioxidants Jan 8, 2008
Cranberries vary in antioxidant bioavailability based on the sugars their anthocyanins are bound to. (Credit: Photo by Keith Weller). (Science Daily)
January American Naturalist highlights Jan 5, 2008
"Plants may alter competition by modifying nutrient bioavailability in rhizosphere: a modeling approach" Xavier Raynaud (Universit Paris-Sud and Universit Pierre et Marie Curie-Paris), Benot Jaillard (Laboratoire de Biogochimie du Sol et de la Rhizosphre), and Paul W. Leadley (Universit Paris-Sud). Plants need nutrients such as Nitrogen and Phosphorus from the soil to grow. (EurekAlert!)
Anadys Pharmaceuticals Announces Positive Results for ANA598 in Animal Model of Chronic Hepatitis C Virus Infection Jan 4, 2008
The selection of ANA598 represented the culmination of a comprehensive structure-based drug design program directed towards NS5B. ANA598 was selected based on an optimized balance of preclinical properties, including intrinsic potency as an NS5B inhibitor, cellular activity in the replicon assay, oral bioavailability and early indicators of safety and tolerability. ANA598 is a low-nanomolar inhibitor of HCV genotype 1a and 1b replicons. (PR Newswire)
Alexza Announces Partnership With Endo for AZ-003 (Staccato(R) fentanyl) in North America Dec 28, 2007
These data suggest complete bioavailability of the inhaled dose. Mean peak arterial plasma concentrations were observed within 30 seconds for both administration routes. (PR Newswire)
Consumer Demand For Antioxidants Has Outpaced Scientific Knowledge Dec 20, 2007
Many past studies on the potential health benefits of these compounds have been done in animals and their exact effects in humans are uncertain, he notes, without adequate attention to bioavailability -- how much of a dose actually can be used by the body -- and how phytochemicals interact with prescription drugs ... "Commentary: Bioavailability of Flavonoids and Polyphenols -- Call to Arms". (Science Daily)
Eurand Completes New Drug Application for Zentase Dec 20, 2007
Also included in the NDA were results from a gastrointestinal (GI) bioavailability study of Zentase conducted in chronic pancreatitis patients in the U.S., which was completed in November 2007 ... Eurand's technology platforms include bioavailability enhancement of poorly soluble drugs, customized release, taste-masking/fast-dissolving formulations and drug conjugation. (Primezone Releases)
Mannkinds Technosphere inhalable insulin likely to fail; potential negative pulmonary effects cited, physicians say Dec 11, 2007
Regarding physician comments on the lower bioavailability of inhaled insulin, Mann said TI is almost four times greater than the bioavailability of Exubera or Eli Lillys AIR inhaled insulin system ... Still, it is known that inhaled insulin has lower bioavailability, so higher doses are required, physicians argued. (FT.com -- Markets)
Waterborne carbon increases threat of environmental mercury Dec 11, 2007
Because DOC is virtually ubiquitous in aqueous environments, its effect on mercury processing may be an important factor in determining mercury bioavailability. Moreau and his colleagues are now working to understand how DOC promotes methylation. (EurekAlert!)
Diet And Cancer Prevention: New Evidence For The Protective Effects Of Fruits And Veggies Dec 8, 2007
More than 70 percent of the ITCs present in the extracts were excreted into the urine as ITC equivalents (ITCs + DTCs) in 12 hours after a single oral dose, indicating high bioavailability and rapid urinary excretion. What is more striking, Zhang says, is that the concentrations of ITC equivalents in the urine of extracts-treated rats were two to three orders of magnitude higher than those in plasma, indicating that the bladder epithelium is most exposed to orally dosed ITCs. (Science Daily)
Between water and rock -- a new science Dec 1, 2007
And impact on bioavailability is still unknown. . (EurekAlert!)
Positive Outcome of Drug-Drug Interaction Trial With Intravenous Iclaprim Nov 21, 2007
An oral formulation of iclaprim has successfully completed three Phase I trials: an ADME study (absorption, distribution, metabolism and excretion) with radiolabelled compound, a Phase I bioavailability trial with a solution and one with a capsule formulation. Iclaprim could be offered not only as an intravenous therapy for hospital use in acute situations, but also as an oral formulation, allowing early patient discharge followed by outpatient treatment. (PR Newswire)
Is plasma vitamin C an appropriate biomarker of vitamin C intake? A systematic review and meta-analysis Nov 13, 2007
Our findings show that FFQ and DR/diary have a moderate relationship with plasma vitamin C. The correlation may be affected/influenced by the presence of external factors such as vitamin bioavailability, absorption condition, stress and food processing and storage time, or by error in reporting vitamin C intake. The complete article is available as a. (Nutrition Journal)
Infinity Announces Hedgehog Pathway Inhibitor Agreement With AstraZeneca Nov 12, 2007
I am tremendously enthusiastic about the preclinical data emerging on IPI-926, our lead Hedgehog candidate, including potent and selective inhibition of the pathway, oral bioavailability, and an extended half-life,'' added Julian Adams, Ph ... In preclinical studies, IPI-926 has shown potent and selective inhibition of the Hedgehog pathway and attractive pharmacological properties including oral bioavailability and extended half-life. (Primezone Releases)
Eurand Reports Third Quarter 2007 Key Achievements and Financial Results Nov 9, 2007
5 million milestone payment from GlaxoSmithKline's ("GSK") following the successful completion of a pivotal bioequivalence study of EUR-1048 - On track to complete bioavailability study of lead product candidate, Zentase (EUR-1008), in November 2007, with anticipated NDA submission before the end of 2007 - Commenced $5 ... Eurand expects to complete its gastrointestinal (GI) bioavailability study of Zentase before the end of November 2007 ... Eurand's technology platforms include customized drug... (Primezone Releases)
Epiphany Biosciences Has Initiated Enrollment in Shingles Study with Valomaciclovir (MIV-606, EBP-348) Licensed From Medivir Nov 8, 2007
Valomaciclovir is a highly potent anti-viral with enhanced delivery and bioavailability. The initiation of this dose-finding study is an important milestone in our development of valomaciclovir, said Fred Volinsky, MD, Chief Executive Officer. (BusinessWire)
Curry-derived molecules might be too spicy for colorectal cancers Nov 5, 2007
Unfortunately, natural curcumin has what researchers term low bioavailability -- the molecule quickly loses its anti-cancer attributes when ingested, Shibata says. With the aim of improving the therapeutic potential of curcumin, Shibata and his colleagues synthesized and tested 90 variations of the molecules structure. (EurekAlert!)
Cancer Targets On The Horizon: Emerging Therapies And Novel Targets Oct 27, 2007
"More importantly, this particular molecule isn't our final candidate, yet, as we are refining its chemical structure to improve bioavailability and increase potency," Kelland said. Nerve-sparing therapy with oncolytic herpes virus for cancers with neural invasion. (Science Daily)
Grape Consumption Improves Antioxidant Capacity in Humans Oct 13, 2007
The key is "bioavailability," the body's ability to process and use the antioxidants. "This research reinforced the fact that grapes are a great source of beneficial antioxidants that are bioavailable and able to improve antioxidant status in humans," said Kathleen Nave, president of the California Table Grape Commission. (PR Newswire)
Avicena to Present at 4th Annual BIO InvestorForum Conference Oct 9, 2007
D., will present an overview of the company and its clinical programs, including an update on activities to build its drug pipeline and investigate new delivery vehicles to enhance the bioavailability of its lead drug candidates. Dr. Tsao-Nivaggioli will be presenting on Thursday, October 11 at 10:30 a.m. (EDT) in the Twin Peaks North room. (PR Newswire)
Chemical Compound Found In Tree Bark Stimulates Growth, Survival Of Brain Cells Oct 6, 2007
"Humans actually have a naturally occurring molecule in the body, Nerve Growth Factor (NGF), which stimulates the growth and differentiation of certain types of nerve cells. However, NGF has poor pharmocokinetics and bioavailability when synthetically manufactured and used therapeutically, and it is also expensive to produce," according to Dr. Keqiang Ye, associate professor of pathology and laboratory medicine at Emory University. "Previous research had focused on copying the chemical structure... (Science Daily)
Poorly Waged Patent Battle Becomes International Controversy Oct 3, 2007
Novartis claims that the beta crystalline form of imatinib mesylate, covered by its 1998 Indian patent application, provides 30 percent more bioavailability than the 1993 compound; in other words, it is more easily absorbed by the body. Section 3(d) adds another hurdle to patentability as defined elsewhere in the world, says Novartis' Shahani. (Law.com)
Eurand to Present At the UBS Global Life Sciences Conference Sep 18, 2007
Eurand's technology platforms include bioavailability enhancement of poorly soluble drugs, customized release, taste-making/fast-dissolving formulations and drug conjugation. Eurand is a global company with facilities in the USA and Europe. (Primezone Releases)
Taxol bristle ball: a wrench in the works for cancer Sep 13, 2007
"We looked for an approach that would clear the major hurdles people have encountered -- solubility, drug efficacy, bioavailability and uniform dispersion -- and our initial results look very promising.". The research is available online and will appear in the Sept. 19 issue of the Journal of the American Chemical Society (J. Am. (EurekAlert!)
Jamieson unveils Resveratrol Red Wine Extract, a made-in-Canada toast to good heart health Sep 10, 2007
The patented Phytosome complex greatly enhances the bioavailability of the OPCs. Resveravine is standardized to contain transresveratrol, which is more bioavailable than the CIS form of this nutrient. (Canada Newswire)
Chelsea Therapeutics Resolves Bioavailability Issue and Reports Greater Than 10-Fold Improvement in Relative Bioavailability of New CH-1504 Formulation Sep 10, 2007
CHARLOTTE, N.C., Sept. 10, 2007 (PRIME NEWSWIRE) -- Chelsea Therapeutics International, Ltd. (NasdaqCM: - ) reported results from its human bioequivalence study quantifying the improvements in relative bioavailability demonstrated by the disodium salt formulation of CH-1504 and identifying the doses to be used in a Phase II evaluation in the treatment of rheumatoid arthritis ... 4-fold improvement in relative bioavailability, as measured by area under the curve (AUC). (Primezone Releases)
Exelixis Reports Encouraging Interim Data From a Phase 2 Trial of XL647 as First-Line Therapy for Non-Small Cell Lung Cancer Sep 5, 2007
The compound has been optimized for high potency and oral bioavailability (using in vivo systems), demonstrates excellent activity in target-specific cellular functional assays and has shown sustained inhibition of target RTKs preclinically in vivo following a single oral dose. Two phase 2 trials in patients with NSCLC are ongoing. (PR Newswire)
Is Soy Milk Good for You? Aug 29, 2007
Beverages fortified with calcium carbonate, however, have been shown to be just as bioavailable (bioavailability is the extent to which the body can use a dietary source) as the calcium from cow s milk (Zhao al. 2005) ... Zhao Y, Martin BR, Weaver CM. Calcium bioavailability of calcium carbonate fortified soymilk is equivalent to cow's milk in young women. (Suite101.com)
EPA takes closer look at St. Joe Park Aug 23, 2007
Studies to determine the bioavailability of ingested chat and tailings from the mining waste sites have been conducted here by EPA. Lead from the chat and tailings had a 20 percent availability rate. Regular soil contaminated with lead, composited from area yards, was 40 percent. (Park Hills Daily Journal, MO)
Bioengineering To Prevent Iron Deficiency? Aug 14, 2007
Dietary iron bioavailability (the measure of iron which can be absorbed from food) is low in populations consuming monotonous plant-based diets with little meat ie ... They conclude: Selective plant breeding and genetic engineering are promising new approaches to improve dietary iron bioavailability, however a major challenge is to show that they can increase iron content to nutritionally useful levels and that the additional iron is bioavailable. (Science Daily)
LifeCycle Pharma and Sciele Pharma Announce FDA Approval of New Formulation of Fenofibrate in 120 mg. and 40 mg. Dosage Strengths Aug 13, 2007
This fenofibrate utilizes LifeCycle Pharma's Meltdose(R) technology which is designed to provide enhanced absorption and greater bioavailability. Under the terms of the agreement with Sciele, LifeCycle Pharma has already received an up-front payment of $5 million, and will receive a further $4 million milestone payment now that this fenofibrate product has received FDA approval. (Canada Newswire)
Biovail Reports Second-Quarter 2007 Financial Results Aug 8, 2007
The issue raised by the FDA in its letter related to the design of the pharmacokinetic studies required to support the NDA. Biovail's NDA included a single-dose, fed and fasted bioavailability study; a single-dose, dose-proportionality study; and a multiple-dose, bioequivalence (BE) study comparing BVF-033 to bupropion hydrochloride. The FDA contends that a single-dose, comparative BE study should have been conducted instead of the multiple-dose BE study in Biovail's NDA. Biovail believes the... (Canada Newswire)
Goats' Milk Is More Beneficial To Health Than Cows' Milk, Study Suggests Aug 1, 2007
This project, conducted by Doctor Javier D;az Castro and directed by professors Margarita S;nchez Campos, M Inmaculada L;pez Aliaga and M Jos; Mu;oz Alf;rez, focuses on the comparison between the nutritional properties of goat milk and cow milk, both with normal calcium content and calcium enriched, against the bioavailability of iron, calcium, phosphorus and magnesium ... Due to the higher bioavailability of iron, calcium, phosphorus and magnesium, the restoration of altered haematological... (Science Daily)
