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    Nicotine Replacement Drug's Bad Trip  Aug 27, 2008
    The drug works as a partial agonist, meaning it binds to the receptor, producing moderate stimulation intended to stave off nicotine withdrawal ... In cell studies, varenicline also acts as a potent full agonist for another receptor subtype called alpha7 that is associated with some of the positive cognitive effects of nicotine, such as enhanced focus. (Scientific American)

    Potential Diabetes Treatment Selectively Kills Autoimmune Cells From Human Patients  Aug 27, 2008
    Since TNF interacts with immune cells through two different receptors TNFR1 and TNFR2, which activate different signaling pathways the researchers next tested several TNF agonists, substances that mimic the molecule's actions. One of those TNF agonists acts through TNFR1, which is expressed on all T cells, and three act through TNFR2, only found on subpopulations of T cells ... While neither the TNFR1 agonist nor two of the three substances that activate the TNFR2 pathway had any significant... (Science Daily)

    Drug Combo Cuts COPD Lung Function Loss  Aug 19, 2008
    According to the second August issue of American Journal of Respiratory and Critical Care Medicine, a combination of salmeterol, a -agonist, and fluticasone propiniate, an inhaled cortical steroid, proved a successful therapy in a randomized, double-blind, placebo-controlled trial conducted in 42 countries. "Pharmacotherapy with salmeterol plus fluticasone propionate, or the components, reduces the rate of decline on [lung function] in patients with moderate to severe COPD, thus slowing disease... (MEDLINEplus)

    Hope for patients with COPD  Aug 16, 2008
    The Toward a Revolution in COPD Health (TORCH) study investigated the effects of combined salmeterol, a -agonist, and fluticasone propiniate, an inhaled cortical steroid, either alone or in combination, on mortality, exacerbations, health-related quality of life and rate of decline in lung function as measure by forced expiratory volume in one second (FEV1) in patients with COPD.. The results are published in the second issue for August of the American Journal of Respiratory and Critical Care... (EurekAlert!)

    Chemokine Therapeutics Announces Second Quarter 2007 Financial and Operating Results  Aug 11, 2008
    - Issuance of U.S. patent "CXC Chemokine Receptor 4 Agonist Peptides". - Positive breast cancer data presented at Joint Metastasis Research Society - American Association for Cancer Research Conference. (CCNMatthews Press Releases)

    TorreyPines Therapeutics Announces Management Change and Second Quarter 2008 Financial Results  Aug 9, 2008
    "We are currently preparing for our end of Phase II meeting with the FDA on September 29th during which we will discuss our proposed Phase III migraine program for tezampanel. In addition, we are continuing to advance NGX426, the oral version of tezampanel, having initiated a Phase I clinical trial to evaluate its analgesic effect. We anticipate announcing results from this Phase I trial by the end of the year, as well as announcing results from an ongoing Phase II clinical trial of our lead... (PR Newswire)

    Anadys Pharmaceuticals to Present at the Bank of America 2008 Specialty Pharmaceuticals Conference  Aug 2, 2008
    For the treatment of chronic hepatitis C, the Company is developing ANA598, a non-nucleoside polymerase inhibitor, and ANA773, an oral TLR7 agonist prodrug. The Company is also developing ANA773 for the treatment of cancer. (PR Newswire)

    Cannabis-Linked Cell Receptor Might Help Prevent Colon Cancer  Aug 1, 2008
    "Potential application of cannabinoids as anti-tumor drugs is an exciting prospect, because cannabinoid agonists (synthetic molecules that mimic the action of natural molecules) are being evaluated now to treat the side effects of chemotherapy and radiation therapy," DuBois said. "Turning CB1 back on and than treating with a cannabinoid agonist could provide a new approach to colorectal cancer treatment or prevention.". (Health-Finder)

    Possible Cause of Postpartum Depression Pinpointed  Aug 1, 2008
    Treatment with THIP (Gaboxadol), a GABA receptor agonist originally intended to treat sleep disorders, ameliorated these effects in mice containing decreased levels of GABA receptors. "Our thinking is that postpartum depression, and maybe premenstrual syndrome and premenstrual dysphoric disorder, may be due to impaired trafficking of these [GABA] receptors to the [neural] membrane," Mody said. (MEDLINEplus)

    Turned-off cannabinoid receptor turns on colorectal tumor growth  Aug 1, 2008
    Agonists are synthetic molecules that mimic the action of a natural molecule. "Potential application of cannabinoids as anti-tumor drugs is an exciting prospect, because cannabinoid agonists are being evaluated now to treat the side-effects of chemotherapy and radiation therapy," DuBois said ... "Turning CB1 back on and then treating with a cannabinoid agonist could provide a new approach to colorectal cancer treatment or prevention.". (EurekAlert!)

    Nventa Wins European Patent Challenge Covering Lead Product Candidate HspE7 and Other HPV Therapeutics  Jul 29, 2008
    HspE7 incorporates the proprietary adjuvant, Poly-ICLC, a toll-like receptor-3 (TLR3) agonist. An adjuvant is a substance added to vaccines to improve immune responses against target antigens. (Canada Newswire)

    Imiquimod, an immune response modifier, is dependent on the OGF-OGFr signaling pathway  Jul 25, 2008
    Imiquimod has been reported to be a toll-like receptor-7 agonist, and its anti-tumor effect exerted by modification of the immune response and stimulation of apoptosis. The mechanism of imiquimod on cell proliferation is unclear. (EurekAlert!)

    Prescription for Addiction: Painkillers for stomach condition spiraled out of control, almost ending man's life  Jul 21, 2008
    The primary active ingredient in Suboxone is buprenorphine, a partial opioid agonist. Suboxone's opioid effects are limited compared with those produced by full opioid agonists, such as oxycodone ... At that point, Barnes recommended he begin taking Naltrexone, which like Suboxone works as an opiate antagonist, or blocker. (Missoulian, MT)

    Salmeterol for Asthma May Cause Serious Events  Jul 19, 2008
    Salmeterol is a long-acting beta2-adrenergic receptor agonist that comes as a dry powder and is administered with a special inhaler. It is also sold under the trade name Serevent. (MEDLINEplus)

    Gonadotropin-releasing hormone agonist use in men without a cancer registry diagnosis of prostate cancer  Jul 14, 2008
    Use of gonadotropin-releasing hormone (GnRH) agonists has become popular for virtually all stages of prostate cancer ... Such cases may be missed by tumor registries, leading to underestimates of the total extent of GnRH agonist use ... We used linked Surveillance, Epidemiology and End-Results (SEER)-Medicare data from 1993 through 2001 to identify GnRH agonist use in men with either a diagnosis of prostate cancer registered in SEER, or with a diagnosis of prostate cancer based only on Medicare... (BioMed Central)

    Chemokine Therapeutics Announces Issuance of U.S. Patent  Jul 2, 2008
    Patent No. 7,378,098 entitled "CXC Chemokine Receptor 4 Agonist Peptides" is related to treatment of patients in need of bone marrow or stem cell transplantation. This patent is based on evidence that treatment with SDF-1 chemokine analog prevents reduction of normal bone marrow stem cells and restores white blood cells, which reduce susceptibility to infections in cancer patients following chemotherapy treatment. (CCNMatthews Press Releases)

    Parkinson's Drugs Again Linked to Compulsive Disorders  Jun 27, 2008
    WEDNESDAY, June 25 (HealthDay News) -- People taking dopamine agonists to treat Parkinson's disease are at risk for impulse-control disorders such as compulsive gambling, buying and sexual behavior, University of Pennsylvania researchers report ... In the study, Weintraub's team looked at these compulsive behaviors in 3,090 patients taking dopamine agonists for Parkinson's disease and Parkinson's patients not taking these drugs ... Weintraub's team found a twofold to threefold increased risk for... (MEDLINEplus)

    Opioids And Cannabinoids Influence Mobility Of Spermatozoids  Jun 25, 2008
    Some of these substances (agonists) are capable of activating the cells, just like a key opening a lock. Others (antagonists), although fitting perfectly into the locks , are not capable of opening them and have the effect of blocking the receptor ... Mr Agirregoitia studied both processes, incubating human sperm with agonist and antagonist synthetic substances to this end. (Science Daily)

    GSK Update on FDA Review of Promacta(R) (Eltrombopag)  Jun 21, 2008
    About Promacta(R) (Eltrombopag) Eltrombopag, a novel oral thrombopoeitin (TPO) receptor agonist, if approved, would be the first oral short-term treatment of previously treated patients with chronic ITP to increase platelet counts and reduce or prevent bleeding. In the pivotal studies, the most common adverse events observed in patients taking eltrombopag were headache, common cold, and nausea. (PR Newswire)

    A lose-lose situation  Jun 21, 2008
    Mary Martin, 63, a Toronto woman, started taking one of the "dopamine agonist" drugs for her Parkinson's symptoms about 18 months ago, finding that it transformed her quality of life ... Mr. Treyes was earlier taken off dopamine agonists, but research indicates that compulsive gambling behaviour can continue even after the medication is stopped. (National Post)

    U.S. FDA Approves Requip(R) XL(TM), the First and Only Oral Once-Daily Non-Ergot Dopamine Agonist for Parkinson's Disease  Jun 14, 2008
    Requip XL is the first and only oral once-daily non-ergot dopamine agonist indicated for Parkinson's disease ... Requip XL offers physicians and patients a simple titration regimen; it also offers a convenient, once-daily dosing schedule compared to other oral dopamine agonists, which are dosed multiple times a day. (PR Newswire)

    Mechanism Explains Link Between Apolipoprotein E And Alzheimer's Disease  Jun 14, 2008
    Importantly, use of an LXR agonist to increase lipidated forms of ApoE in a mouse model of AD resulted in reduced A plaque levels and an improvement in contextual memory ... "Our data suggest that therapeutic agents that increase the levels of lipidated forms of ApoE, including LXR agonists, represent a potentially efficacious therapy for AD," concludes Dr. Landreth. (Science Daily)

    Amylins Byetta LAR reports injection site reactions and patient problems with mixing  Jun 13, 2008
    Other physicians interviewed by this news service also agreed that the attractiveness of a once-weekly GLP-1 agonist such as Byetta LAR may outweigh concerns over current problems with delivery ... Novo is likely to have an excellent delivery device, if past performance is anything to go by, he said, alluding to the fact that Novo Nordisks once-daily GLP-1 agonist, liraglutide, may be on the market ahead of Byetta LAR. Novo has touted the benefits of its needle delivery system for... (FT.com -- Markets)

    Vitamin A & Urocholine for Autism  Jun 10, 2008
    Providing natural cis vitamin A supplements in the form of cod liver oil along with the alpha muscarinic receptor agonist Urocholine has generated dramatic, immediate benefits for some autistic children, including enhanced social interaction, improved attention and language usage, better vision and improved sleep. Vitamin A supplements may be beneficial for children who engage in sideways glancing, as this may indicate improper function of the rods in the eye, a symptom of defective G-alpha... (Suite101.com)

    InteKrin Therapeutics Presents Phase 2a Data at American Diabetes Association Meeting for INT131, a non-TZD SPPARM  Jun 9, 2008
    INT131 was safe and well tolerated, without evidence of the recognized side effects of the full agonist TZDs at a dose that provides glycemic improvement as good as or better than the highest approved doses of Actos(R) and Avandia(R). "INT131 has consistently demonstrated potent and selective PPAR-gamma modulation through each phase of development and, this clinical data is an important step in that continued progression. This Phase 2a data demonstrate that it may be possible to achieve... (PR Newswire)

    New Diabetes Compound AVE0010 Showed Clear Dose Response Results With Once-A-Day Injection in Phase IIb Study  Jun 8, 2008
    Results Presented at the ADA's Annual Scientific Sessions SAN FRANCISCO, June 7 /PRNewswire-FirstCall/ -- Sanofi-aventis announced today that the results of the dose-finding study for its new injectable diabetes compound AVE0010, a GLP-1 agonist, were presented at the American Diabetes Association's (ADA) 68th Annual Scientific Sessions meeting in San Francisco, California ... "The results of the once daily AVE0010 regimen are very promising and this new GLP-1 agonist has a potential to become... (PR Newswire)

    Sanofi diabetes drug shows promise in study  Jun 8, 2008
    "The results of the once daily AVE0010 regimen are very promising and this new GLP-1 agonist has a potential to become an important addition to the treatment armamentarium for type 2 diabetes," Robert Ratner, the study's lead investigator, said in a statement. In addition to lowering blood glucose levels, the drug led to modest weight loss, a highly desirable effect in diabetes treatments as is a leading cause of the disease. (Scientific American)

    FDA Taking Another Look at Chantix  Jun 1, 2008
    Chantix is a popular anti-smoking drug made by Pfizer, Inc. It was approved in 2006, and was the first nicotine receptor partial agonist - meaning it blocks nicotine receptors in the brain - on the market. Last Tuesday, the Institute for Safe Medication Practices issued a report detailing Chantix adverse event repots to the FDA. The report specifically cited 224 reports of potential heart-rhythm disturbances, 372 reports of possible movement disorders and 544 reports of likely glycemic... (Newsinferno.com)

    Prucalopride Relieves Constipation with No Signs of Heart Risk  May 31, 2008
    Personalize Your Medical News. Saturday, May 31, 2008. (MedPage Today)

    A Placebo-Controlled Trial of Prucalopride for Severe Chronic Constipation  May 29, 2008
    Background In this 12-week trial, we aimed to determine the efficacy of prucalopride, a selective, high-affinity 5-hydroxytryptamine4 receptor agonist, in patients with severe chronic constipation. Methods In our multicenter, randomized, placebo-controlled, parallel-group, phase 3 trial, patients with severe chronic constipation. (New England Journal of Medicine)

    The Long and Short of a Constipation-Reducing Medication  May 29, 2008
    Prucalopride is a prokinetic 5-hydroxytryptamine4 (5-HT4) receptor agonist similar in function to cisapride and tegaserod, two constipation-reducing drugs. . (New England Journal of Medicine)

    Review Suggests Asthma Drugs Safe, Effective in COPD  May 28, 2008
    NEW YORK (Reuters Health) - Previous research has linked a class of asthma drugs known as long-acting beta agonists to increased risk of adverse respiratory-related events or death in patients with COPD (chronic obstructive pulmonary disease) ... The new report suggests that long-acting beta agonists have beneficial effects in patients with moderate-to-severe COPD and do not appear to increase the risk of respiratory deaths ... Examples of long-acting beta agonists used to treat asthma and other... (MEDLINEplus)

    Tioga Pharmaceuticals' Asimadoline Demonstrates Positive Results in a Phase 2b Clinical Trial for the Treatment of Irritable Bowel Syndrome  May 21, 2008
    Statistically Significant Reduction of IBS Pain and Normalizing Motility Effect Observed SAN DIEGO, May 20 /PRNewswire/ -- Tioga Pharmaceuticals, Inc. today announced the results of a recent Phase 2b study of its oral kappa opioid receptor agonist, asimadoline, which demonstrated statistically significant results in the treatment of Irritable Bowel Syndrome (IBS). Asimadoline produced significant improvement in diarrhea-predominant (D-IBS) and alternating (A-IBS) patients across multiple... (PR Newswire)

    Study analyzed SYMBICORT in children with persistent asthma  May 21, 2008
    5 Administered twice daily, SYMBICORT is a combination of two proven asthma medications budesonide, an inhaled corticosteroid (ICS), and formoterol, a rapid and long-acting beta2-agonist (LABA) ... Long acting beta2-adrenergic agonists may increase the risk of asthma-related death ... Data from a large placebo-controlled U.S. study compared the safety of another long-acting beta2-adrenergic agonist (salmeterol) or placebo added to usual asthma therapy showed an increase in asthma-related... (EurekAlert!)

    Concomitant treatment with nebulized formoterol fumarate & tio-significant improvements -- COPD  May 21, 2008
    Concomitant Treatment with Nebulized Formoterol and Tiotropium in Subjects with COPD: A Placebo-Controlled Trial, published in Respiratory Medicine, assesses the efficacy and safety of the concomitant treatment of Perforomist nebulized formoterol fumarate (a long-acting -agonist [LABA]) and tiotropium (an anticholinergic) in 130 adults with moderate to severe COPD. ... Formoterol fumarate is a rapid and long-acting beta2-agonist (LABA) that has been previously available in the U.S. in a dry... (EurekAlert!)

    Drugs for Restless Legs Syndrome Have Downsides  May 14, 2008
    White and his colleagues looked at 14 trials of four nonergot dopamine agonist (NEDA) drugs, one of which never reached the market. The other three, pramipexole (Mirapex), ropinirole (Requip) and rotigotine (Neupro) are the mainstays of treatment for a condition that affects 5 percent to 10 percent of American adults. (MEDLINEplus)

    Anadys Pharmaceuticals to Present at Two Upcoming Investor Conferences  May 13, 2008
    The Company is developing ANA598, a non-nucleoside polymerase inhibitor for the treatment of chronic hepatitis C and ANA773, an oral TLR7 agonist prodrug for cancer. Safe Harbor Statement Statements in this press release that are not strictly historical in nature constitute "forward-looking statements." Such statements include, but are not limited to, references to Anadys' strategy, development programs, and ability to develop novel medicines in the areas of hepatitis C and oncology. (PR Newswire)

    Shire investigational nonstimulant INTUNIV showed significant efficacy in reducing ADHD symptoms  May 8, 2008
    WASHINGTON, May 7 -- Shire plc(LSE: SHP, Nasdaq: SHPGY), the global specialty biopharmaceutical company, presented today at a major scientific meeting findings from analyses of pivotal trial results of INTUNIV, a selective alpha-2A-agonist ... Upon approval, INTUNIV will be the first selective alpha-2A receptor agonist indicated for the treatment of ADHD that may provide an important treatment option for patients and physicians ... The selective alpha-2A agonist strengthens working memory and... (EurekAlert!)

    Cephalon Announces FDA Advisory Committee Recommendation Against Approval of an Expanded Label for FENTORA  May 7, 2008
    (See DOSAGE AND ADMINISTRATION.) FENTORA contains fentanyl, an opioid agonist and a Schedule II controlled substance, with an abuse liability similar to other opioid analgesics. FENTORA can be abused in a manner similar to other opioid agonists, legal or illicit. (PR Newswire)

    Parkinson's Drugs Tradeoff: Better Muscle Control, Worse Side Effects, Review Shows  Apr 21, 2008
    20, 2008) Compared to older drugs for Parkinson disease, a newer class of medications called dopamine agonists might be better at preventing some of the disabling muscle control problems associated with the disease and its treatment, a new review of recent studies concludes ... However, patients who take dopamine agonists suffer from an increase in numerous side effects -- from sleepiness to nausea to hallucinations in some cases -- and are more likely to drop out of treatment than those who... (Science Daily)

    Treximet(TM) (Sumatriptan and Naproxen Sodium) Tablets Approved by FDA for Acute Treatment of Migraine  Apr 16, 2008
    Since Treximet contains sumatriptan, it should not be administered with another 5-HT1 agonist. Treximet is contraindicated in patients with hepatic impairment. (PR Newswire)

    CV Therapeutics may get up to $185M in royalty deal  Apr 16, 2008
    The U.S. Food and Drug Administration approved Lexiscan injection, an A2A adenosine receptor agonist, for use as a pharmacologic stress agent for patients unable to undergo adequate exercise for stress tests. CV Therapeutics retains rights to the other 50 percent of royalty revenue from North American sales of the product, and also may receive a royalty on another Astellas product under the terms of the company's collaboration agreement with Astellas Pharma US Inc.. (San Jose Business Journal)

    Penn researchers find targeted therapy combination overcomes treatment resistance in liver cancer  Apr 14, 2008
    Source: AACR abstract #833 Sorafenib sensitizes hepatocellular carcinoma cells to TRAIL or TRAIL receptor agonist antibodies Junaid Abdulghani, Patrick A. Mayes, David T. Dicker, Charles D. Smith, Robin C. Humphreys, Wafik S. El Deiry. University of Pennsylvania, Philadelphia, PA, Medical University of Southern Carolina, Charleston, SC, Human Genome Sciences, Rockville, MD.. (EurekAlert!)

    CV Therapeutics and Astellas Announce FDA Approval for Lexiscan(TM) (regadenoson) Injection  Apr 11, 2008
    -First A2A Adenosine Receptor Agonist Approved for Use as Pharmacologic Stress Agent in Myocardial Perfusion Imaging- PALO ALTO, Calif ... April 10 /PRNewswire-FirstCall/ -- CV Therapeutics, Inc. (Nasdaq: ) and Astellas Pharma US, Inc. today announced that the U.S. Food and Drug Administration (FDA) has approved Lexiscan(TM) (regadenoson) injection, an A2A adenosine receptor agonist, for use as a pharmacologic stress agent in radionuclide myocardial perfusion imaging (MPI) -- a test that detects... (PR Newswire)

    First do no harm? UH prof taking opposite approach to treat asthma  Apr 10, 2008
    Although counterintuitive, Bonds studies are reminiscent of hair-of-the-dog folk wisdom to treat like with like, in this case using beta blockers (or antagonists) instead of stimulants (or agonists) in asthmatics ... And even if I am correct about beta blockers ultimately being used in the treatment of asthma, there probably always will be a need for the inhaler-type agonist drugs to handle acute asthma attacks. (EurekAlert!)

    Drug Used To Treat Bipolar Disorder Has Potential For Treating Alcohol Dependence  Apr 8, 2008
    "Aripiprazole is a dopamine partial agonist," explained Henry R. Kranzler, a professor in the department of psychiatry at the University of Connecticut Health Center and corresponding author for the study ... "Other antipsychotic drugs -- such as haloperidol and, olanzapine, which are full dopamine antagonists -- reduce the pleasurable effects of alcohol, but they are associated with more adverse effects than aripiprazole is. The list of side effects associated with most medications that exert... (Science Daily)

    MediciNova Initiates Phase II Clinical Trial of MN-221 in Status Asthmaticus Patients  Mar 31, 2008
    MN-221 is highly-selective Beta2-adrenergic receptor agonist. Preclinical testing in vitro and in vivo shows MN-221 to be more selective for the Beta2-adrenergic receptor than other Beta2-adrenergic receptor agonists commonly used these asthma attacks ... This improved selectivity, coupled with its partial agonist activity at Beta1-adrenergic receptors, may result in fewer cardiovascular side effects than are commonly observed with these other agents. (Primezone Releases)

    Supercharge Your New Year's Exercise Program  Mar 28, 2008
    "Keep in mind, Stemulite is made from all-natural ingredients and contains several very effective and targeted natural proteins, enzymes and amino acids, including a stem cell agonist and a trace mineral called indium," says Dr. Sommers. Stemulite has been observed to have the following effects on the body. (Fairfax Chronicle, VA)

    Building Strength and Muscle without Illegal Substances  Mar 25, 2008
    Summers further stated, "I have spent the last two years on my newest formulation and next generation natural fitness supplement for men and women called Stemulite. It is a stronger formulation than Endothil and now has seven key all-natural ingredients of very effective and targeted natural proteins, enzymes and amino acids, including a stem cell agonist and a trace mineral called indium.". Stemulite, the core muscle building ingredient, is a natural dietary adult stem cell agonist. (Harrisburg Daily Register, IL)

    Asthma Medicines Often Not Prescribed As National Guidelines Recommend, Study Shows  Mar 20, 2008
    Reliever medications that should be used for only acute symptoms include short-acting beta-agonists that relax muscles in the airways, anticholinergic agents that inhibit nerve impulses, and systemic corticosteroids ... During the time period analyzed, a new kind of controller medication a long-acting beta agonist was federally approved for asthma treatment. (Science Daily)

    Kosan Restructures Workforce to Focus Resources on Lead Clinical Programs  Mar 19, 2008
    Kosan's motilin agonist compound, KOS-2187, licensed to Pfizer, is in a Phase 1 trial in gastroesophageal reflux disease (GERD) ... Kosan's actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of these risks and uncertainties, which include, without limitation, risks related to the uncertain progress and results of Kosan's preclinical and clinical testing, including the risks that studies and trials may not... (PR Newswire)

    Study Finds Potential Cause of Age-Related Macular Degeneration  Mar 19, 2008
    Instead, a Slit2 molecular agonist (that is, a molecular mimic) would need to be developed and tested in humans -- a process that could take a decade or more before arriving in the clinic, he said. AMD is the leading cause of blindness in Americans over the age of 55, according to the American Macular Degeneration Association, affecting more than 10 million individuals. (MEDLINEplus)

    M's Science and Eisai Sign Option Agreement for Sigma Agonist SA4503  Mar 15, 2008
    New 2007Annual Reports. 2001-2008 The Japan Corporate News Network (JCN) K.K.. (JCN Network, Japan)

    ConjuChem Initiates Phase II Study of PC-DAC(TM):Exendin-4  Feb 20, 2008
    Exendin-4, like Glucagon-like peptide-1 (GLP-1), is an insulinotropic peptide and an agonist for the GLP-1 receptor. Exendin-4 decreases glucagon and increases insulin secretion in a glucose-dependent manner. (Canada Newswire)

    Athersys to Host Fourth Quarter 2007 Results Call  Feb 15, 2008
    The company's lead product candidate, ATHX-105, is an oral, selective 5HT2c receptor agonist in clinical development for the treatment of obesity. The company is developing other orally active pharmaceutical product candidates for the treatment of metabolic and central nervous system disorders, utilizing proprietary technologies, including Random Activation of Gene Expression (RAGE). (Primezone Releases)

    AEterna Zentaris Reports First Patients Treated with Anti-Cancer Compound AEZS-108 in Phase 2 Trial in Ovarian and Endometrial Cancers  Feb 12, 2008
    QUEBEC CITY, Feb. 12 /CNW Telbec/ - AEterna Zentaris Inc. (NASDAQ: AEZS; TSX: AEZ), a global biopharmaceutical company focused on endocrine therapy and oncology, today reported that dosing of AEZS-108, a luteinizing hormone-releasing hormone (LHRH) agonist linked to doxorubicin, has commenced in its Phase 2 trial in gynaecological cancers for which patient enrolment had begun in December 2007 ... D., President and CEO of AEterna Zentaris commented, "We are excited to have started dosing patients... (Canada Newswire)

    Labopharm Reports Positive Results for Phase III Study on Once-daily Trazodone  Feb 8, 2008
    About Trazodone Trazodone is an atypical anti-depressant that acts as a dual serotonin agonist and serotonin reuptake inhibitor (SARI). Trazodone appears to increase serotonin activity via three mechanisms: the activation of neuronal serotonin receptors; the inhibition at the neuronal serotonin feedback system which regulates the action of serotonin; and the inhibition of the re-uptake of serotonin. (Canada Newswire)

    Anadys Pharmaceuticals to Present at the BIO CEO & Investor Conference  Feb 6, 2008
    The Company is developing ANA598, a small-molecule, non-nucleoside inhibitor of the NS5B polymerase for the treatment of chronic hepatitis C and ANA773, an oral TLR7 agonist prodrug for cancer. Safe Harbor Statement Statements in this press release that are not strictly historical in nature constitute "forward-looking statements." Such statements include, but are not limited to, references to Anadys' strategy, development programs, and ability to develop novel medicines in the areas of hepatitis... (PR Newswire)

    'I lost 35,000'Patients claim drug led to gambling  Feb 4, 2008
    BI said it was company policy not to comment on litigation but they said it was, "the first pharmaceutical company... to add information about reports of pathological gambling associated with patients", using Mirapex and other dopamine agonists. BI added that, "pathological gambling may also be both part of the disease itself and potentially related to all dopamine agonists," as well as other treatments for Parkinson's such as levidopa ... Mirapex and other similar drugs which are called... (BBC News -- Health)

    Johor steps up foodstuff inspection  Feb 1, 2008
    "We have also sent 22 samples for beta agonist test but the result has yet to be finalised,'' he told a press conference at his office here on Friday. He said imported products such as fruits, mushroom, wax duck and seaweed would be tested for pesticides, colouring, preservative and heavy metal substances. Dr Marzukhi said his officers had seized 620 can foods worth some RM78,000 from these premises. "The canned foods seized were dented, expired or found to have labelling problems and were not... (The Star Online, Malaysia)

    Experimental Weight-loss Drug Cuts Appetite, Burns More Energy, Study Suggests  Jan 11, 2008
    "The ingredient responsible stimulates cannabinoid receptors. When you block the cannabinoid system with an antagonist like taranabant, you suppress appetite." However, the drug, developed by Merck, also comes with an increased risk of adverse side effects at higher doses, the study shows, including mild to moderate gastrointestinal and psychiatric effects. The first proof of concept that so-called cannabinoid 1 receptor (CB1R) inverse agonists might offer an obesity therapy came from studies of... (Science Daily)

    Ministry to ensure safe food for CNY  Jan 11, 2008
    For domestic products, inspections will target meat for banned substances such as beta agonist, expired food products and labelling. Any suspected food product would be seized, he said. (The Star Online, Malaysia)

    New Treatment Mechanisms For Schizophrenia  Jan 10, 2008
    D., lead author on this project, comments, "While treating patients with receptor agonists can be highly effective therapy, drugs that increase the action of the transmitter that activates the same receptor have traditionally been very effective with fewer side effects than chronic agonist treatment." He adds, "These data support the conclusion that NAAG peptidase inhibitors represent a breakthrough in the discovery of a completely novel means of adjunct therapy for schizophrenia that is... (Science Daily)

    Arena Pharmaceuticals Announces APD668 Initial Clinical Study Results Suggest Glucose-Dependent Insulinotropic Receptors May Improve Glucose Control in Patients With Type 2 Diabetes  Jan 8, 2008
    Ortho-McNeil to Continue Investigation of GDIR Agonists Under its Partnership with Arena SAN DIEGO, Jan. 7 /PRNewswire-FirstCall/ -- Arena Pharmaceuticals, Inc. (Nasdaq: ) announced today that initial clinical study results for APD668, an oral drug candidate discovered by Arena and being investigated for the treatment of type 2 diabetes under a partnership with Ortho-McNeil Pharmaceutical, Inc., suggest that Glucose-Dependent Insulinotropic Receptors, or GDIRs, may improve glucose control in... (PR Newswire)

    Taisho to Give Pfizer Overseas Rights for Schizophrenia Drug Candidate  Jan 7, 2008
    said Monday that it will grant U.S. drug giant Pfizer Inc. exclusive rights to develop and sell overseas TS-032, a new drug candidate developed by Taisho to treat schizophrenia (JCN Network, Japan)

    Chua highly experienced  Jan 2, 2008
    GETTING pig farmers to sign a loyalty pledge to not use illegal substances, including beta agonist, on their livestock. He also worked on moves to cut down red tape when poor Malaysians applied for financial help through the ministrys Medical Aid Fund. (The Star Online, Malaysia -- News)

    Hemispherx's CFS Clinical Programs Reviewed in European Community  Dec 28, 2007
    The UK report estimates that between 26,865 and 53,729 people in England and Wales, respectively, are ``severely affected'' with CFS. It recognizes Ampligen(r), an experimental therapeutic, as a new class of toll-like receptor 3 agonist drugs that would, if licensed, be the first pharmaceutical treatment for CFS.. During the 2008 calendar year Hemispherx plans to begin the commercial application process for introducing Ampligen(r) as a CFS therapeutic in the European Community. (Primezone Releases)

    ARYx Therapeutics Provides Update on Product Development -- Reports Results for 2007 Third Quarter  Dec 20, 2007
    A potent agonist of 5-HT4 receptors which exist throughout the GI tract regulating gastric emptying and the motility of food through the intestines, ATI-7505 is engineered to maintain the efficacy of cisapride, a drug that reached peak sales of $1. 0 billion a year prior to being withdrawn from the market in 2000 due to life-threatening cardiac toxicities. (BusinessWire)

    Intensive Care Quality Of Sleep Improved By New Drug, Reports Study  Dec 15, 2007
    14, 2007) A new sedative drug has been shown to improve the sleep quality and comfort levels of intensive care patients, compared to the most commonly-used medication, according to research published in the journal JAMA.. US and UK researchers compared the effects of the new drug dexmedetomidine with the commonly used sedative lorazepam, both of which reduce the pain and anxiety experienced by mechanically ventilated ICU patients and which help them to tolerate invasive procedures such as the... (Science Daily)

    Athersys Commences Trading On NASDAQ Capital Market  Dec 12, 2007
    The company's lead product candidate, ATHX-105, is an oral, selective 5HT2c receptor agonist in Phase I clinical trials for the treatment of obesity. The company is also developing other orally active pharmaceutical product candidates for the treatment of metabolic and central nervous system disorders, utilizing proprietary technologies, including Random Activation of Gene Expression (RAGE). (Primezone Releases)

    * Taiwan News Quick Take  Dec 11, 2007
    Dopamine agonist alert ... Dopamine agonists routinely used to alleviate symptoms of the degenerative disease have been linked to compulsive behaviors such as pathological gambling. (Taipei Times, Taiwan -- World)

    Kosan Presents Updated Data on Hsp90 Inhibitor, Tanespimycin, in Multiple Myeloma at Ash  Dec 9, 2007
    Kosan's motilin agonist, KOS-2187, licensed to Pfizer, is in a Phase 1 safety trial, with plans to pursue development in gastroesophageal reflux disease (GERD). This press release contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995 (the "Act"). (PR Newswire)

    Ligand Presents Positive LGD-4665 Phase I Clinical Trial Results at the American Society of Hematology Annual Meeting (ASH)  Dec 9, 2007
    SAN DIEGO--()--Ligand Pharmaceuticals Incorporated (NASDAQ:LGND) today announced positive results from a Phase I clinical trial with LGD-4665 in a poster titled Single and Multiple Oral Doses of LGD-4665, a Small Molecule Thrombopoeitin Receptor Agonist, Increase Platelet Counts in Healthy Male Subjects, at the American Society of Hematology (ASH) 49th Annual Meeting, being held at the Georgia World Congress Center in Atlanta December 8-11, 2007 ... LGD-4665 is a highly selective full agonist... (BusinessWire)

    Parkinson's drugs 'made me gambler and gay sex fiend'  Dec 9, 2007
    Didier Jambart, a French defence ministry employee, has been suing for damages of 400,000 after being prescribed with dopamine agonist drugs in a case that is being closely studied by lawyers representing Parkinson's sufferers in Britain, the US and Canada ... Dopamine agonists, which mimic the mood chemical dopamine, are used in several branded drugs commonly prescribed for Parkinson's, a debilitating disease which affects some 120,000 people in Britain ... As soon as we saw him we knew... (Guardian Unlimited -- World)

    Hemispherx Biopharma Receives Notice of Incomplete New Drug Application (NDA)  Dec 8, 2007
    The NDA filing rate does not affect ongoing vaccine enhancement programs with Ampligen(r), an experimental TLR3 agonist, or ongoing Treatment IND programs for CFS in the U.S.. About Hemispherx Biopharma. (Primezone Releases)

    Agonist Singer Recalls Painful Time On 'Canadian Idol'; Plus Philip Anselmo & More News That Rules, In Metal File  Dec 8, 2007
    Agonist Singer Recalls Painful Time On 'Canadian Idol'; Plus Philip Anselmo & More News That Rules, In Metal File ... The Agonist (Photo: Century Media) ... It's November 20, and Alissa White-Gluz the comely singer for Canadian metalcore outfit the Agonist is in a hotel room in the middle of Colorado. (VHI.com -- Music News)

    Bionovo Describes a New Class of Therapeutic Compounds  Nov 30, 2007
    - Highly selective estrogen receptor beta agonists have promise for safer therapies in women's health - EMERYVILLE, Calif ... The paper, entitled "Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonist" provides details of the selective transcriptional activation of liquiritigenin to the estrogen receptor beta, highlights the advantages of an estrogen receptor beta targeted drug and discusses the isolation and structural identification of the pure chemical compound... (PR Newswire)

    Eltrombopag and Chronic Idiopathic Thrombocytopenic Purpura  Nov 29, 2007
    Methods We conducted a trial in which 118 adults with chronic ITP and platelet counts of less than 30,000 per cubic millimeter who had had relapses or whose platelet count was refractory to at least one standard treatment for ITP were randomly assigned to receive the oral thrombopoietin-receptor agonist eltrombopag (30, 50, or 75 mg daily) or placebo. The primary end point was a platelet count of 50,000 or more per cubic millimeter on day 43. (New England Journal of Medicine)

    Eltrombopag for Thrombocytopenia in Cirrhosis  Nov 29, 2007
    Background Eltrombopag is a new, orally active thrombopoietin-receptor agonist that stimulates thrombopoiesis. We evaluated its ability to increase platelet counts and facilitate treatment for hepatitis C virus (HCV) infection in patients with thrombocytopenia associated with HCV-related cirrhosis. (New England Journal of Medicine)

    Immune Thrombocytopenic Purpura — From Agony to Agonist  Nov 29, 2007
    NEJM -- Immune Thrombocytopenic Purpura -- From Agony to Agonist ... Immune Thrombocytopenic Purpura From Agony to Agonist. (New England Journal of Medicine)

    Glaxo confident as FDA probes asthma drugs in kids  Nov 27, 2007
    Serevent, a long-acting beta agonist used to ease breathing, is also included in Advair, Glaxo's biggest product with worldwide sales of 3. 3 billion pounds ($6. (Reuters.uk)

    FDA approves ABILIFY(R) (aripiprazole) as the first medication for add-on treatment of MDD  Nov 21, 2007
    The first and only available dopamine partial agonist, ABILIFY is indicated as adjunctive treatment to antidepressant therapy in adults with major depressive disorder. Initially approved in November 2002, over 12. (EurekAlert! -- Business News)

    Sosei and Vectura Announce Start of Phase II Studies of QVA149 for the Treatment of COPD  Nov 15, 2007
    QVA149 is a combination of NVA237, a once-daily long-acting muscarinic antagonist (LAMA) and indacaterol, a once-daily long-acting beta-2 agonist (LABA) ... Novartis is responsible for developing and commercializing NVA237 both as a monotherapy and in combination with indacaterol, its once daily, long acting beta 2 agonist, as QVA149. (PR Newswire)

    Karo Bio Initiates Phase IIb Clinical Study With KB2115  Nov 14, 2007
    KB2115 is a novel, selective, thyroid hormone agonist for treatment of dyslipidemia. Recently Karo Bio presented positive data from a first phase IIa study. (BusinessWire)

    Prostate Cancer Death Risk Higher In Obese Or Overweight Men  Nov 14, 2007
    For the study, the researchers used data from a phase 3 trial involving 945 men with locally advanced prostated cancer who were enrolled between 1987 and 1992 and randomized to receive either radiation therapy and immediate hormone therapy (using goserelin, a GnRH agonist that stops the production of sex hormones), or radiation therapy followed by hormone therapy at recurrence. They were able to get initial height and weight data for 788 of the patients and follow them for 8 years. (Medical News Today)

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