Peakdale Molecular Launches AssayReady4U(TM) in Collaboration With ChemPrintCo LLC Aug 27, 2008
Peakdale has growing capabilities in computational chemistry, analytical chemistry and ADME screening. The application of less commonly used chemistry, including high temperature/pressure reactions, proprietary heterocyclic chemistry and nucleoside synthesis, enables Peakdale's chemists to generate unique compounds for drug discovery. (Canada Newswire)
Cyprotex Introduces New Product Line Cloe(R) Select - a Portfolio of Bespoke ADME and PK Services Apr 2, 2008
It complements the current range of Cloe(R) Screen assays to provide ADME (absorption, distribution, metabolism and excretion) and pharmacokinetic solutions from early discovery through to later stage development projects ... Cyprotex can now offer a fully integrated solution in the area of ADME and pharmacokinetics throughout this entire process ... "Many of our customers rely on us for their ADME projects right from early screening projects through to IND submission. Building these... (PR Newswire)
Taconic Acquires 80% Stake in Artemis Nov 27, 2007
These platforms are being continually expanded, most recently with the addition of mouse models humanized for key drug metabolism enzymes (ADME mice). Artemis customers include most of the leading pharmaceutical companies, biotech firms and many academic institutions in Europe, the United States and Japan. (BusinessWire)
Cyprotex Launches New Cloe(R) Screen Assay to Improve the Prediction of in vivo Pharmacokinetics Jun 7, 2007
Mr. Robert Morrison Atwater, Cyprotex' Chief Executive Officer, comments on the launch of the new service 'Once again Cyprotex proves itself to be foremost in the provision of in vitro ADMET services ... Cyprotex is a specialist provider of ADME data and pharmacokinetic predictive services. (PR Newswire)
MDS Reports Second Quarter 2007 Results Jun 7, 2007
MDS Sciex and its joint venture partners introduced enhancements to the Protein Pilot(TM) software and the 4800 MALDI TOF/TOF(TM) mass spectrometer to support biomarker research; and the FlashQuant(TM), a new technology platform that combines triple-quadrupole mass spectrometry with MALDI technology to streamline the identification of viable drug candidates through better analysis of the absorption, distribution, metabolism, and excretion properties of compounds (ADME). Molecular Devices... (Canada Newswire)
Cyprotex Extends Cloe(R) Screen Mechanism-Based Inhibition Service to Include 4 Additional Cytochrome P450 Isoforms Mar 29, 2007
"We have developed these additional mechanism-based inhibition assays in response to both customer demand and regulatory guidelines. The prevalence and clinical implications of mechanism-based CYP450 inhibition has placed greater emphasis on the early detection of compounds with this potential." Cyprotex is a specialist provider of ADME data and pharmacokinetic predictive services. Our unique Cloe(R) Screen technology which couples robust protocols with state-of-the-art automation enables... (PR Newswire)
SGX Pharmaceuticals Updates Analysts and Investors on Oncology Pipeline Feb 16, 2007
SGX 523 is well tolerated in rodents, has demonstrated in vivo efficacy in mice, and has good safety pharmacology and ADME properties. JAK2 Program -- Through the application of FAST, the Company has generated lead series of potent, selective small molecule JAK2 inhibitors. (PR Newswire)
Cyprotex Adds MDR1-MDCK Permeability Screening Service to the Cloe(R) Screen Range of In Vitro ADMET Assays Oct 24, 2006
The addition of the MDR1-MDCK permeability assay to the Cloe(R) Screen family of in vitro assays further enhances Cyprotex's reputation as a market leader in the provision of ADMET screening services. As with the majority of Cyprotex' high quality ADME screens, the MDR1-MDCK permeability assay uses mass spectrometry as an end-point and employs Cyprotex' state-of-the-art automation capabilities. (PR Newswire)
Animal intelligence Jun 1, 2006
The term ADME-tox describes this battery of tests. The goal of ADME-tox testing is to maximize safety and efficacy predictions so as to minimize drug-development costs ... Maths graduates may find entry-level jobs doing biostatistical programming for ADME-tox groups. (Nature News Service)
