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As a robust approach, we used a combination normalisation factor (NF), calculated using the geNorm application, based on the geometric mean of three selected reference genes: glyceraldehyde-3-phosphate dehydrogenase, ubiquitin conjugating enzyme and actin. The effects of normalisation are illustrated using as target gene leukotriene B4 12-hydroxydehydrogenase (Ltb4dh), which was up-regulated following 24 h exposure to 63-81 mg IB/l. (BioMed Central)
New genes implicated in rheumatoid arthritis Jun 27, 2006
The second most significantly over-expressed gene was 11-hydroxysteroid dehydrogenase type 2 (11-HSD2), a steroid pathway enzyme linked to inflammation and bone erosion. This gene was also found over-expressed in the synovial tissue of OA patients. (EurekAlert!)
Personality and parents' alcoholism interact to influence a person's risk of becoming an alcoholic Jun 26, 2006
"This indicates that family history by itself is only one of many variables in the 'equation' predicting alcoholism. Some variables increase the probability of alcoholism in offspring, such as exposure to heavy drinking, or antisocial behavior in parents or offspring, whereas others decrease this risk, such as warm parent-child relationships and certain forms of the alcohol dehydrogenase gene. This study suggests that an individual's personality influences how he or she responds to familial... (EurekAlert!)
- Johnjoe McFadden Jun 6, 2006
David Leys, Nigel Scrutton, Michael Sutcliffe and colleagues at Manchester University, together with Adrian Mulholland at Bristol, have just published a paper in the journal Science that claims that an enzyme called aromatic amine dehydrogenase (AADH) accelerates its chemical reaction by bringing the substrate particles so close to the enzyme that the fog of particle positions overlaps, allowing a proton to "quantum tunnel" from substrate to enzyme. That biochemical reactions involve quantum... (Guardian Unlimited)
Data to be presented on Adherex's Eniluracil at ASCO 2006 Annual Meeting Jun 5, 2006
D., Adherex's Chairman and CEO, said, "Thus far, every aspect of our hypothesis for why GSK's Phase III trials failed has turned out to be correct. In our Phase I trial, we have already demonstrated that a dose of eniluracil one-tenth of that used by GSK effectively inhibits dihydropyrimidine dehydrogenase (DPD) for 48-72 hours. We have been able to increase the dose of 5-FU by 20-fold over the dose used by GSK and believe we are close to identifying the optimal dose. And, as was demonstrated in... (CCNMatthews Press Releases)
Enzyme defect leads to hyperinsulinism May 25, 2006
Bethesda, MD A recent study in the Journal of Biological Chemistry confirms that mutations in an enzyme called glutamate dehydrogenase can cause congenital hyperinsulinism ... One of these genes codes for an enzyme called glutamate dehydrogenase ... This enzyme is stimulated by the amino acid leucine, meaning that protein meals that contain leucine lead to activation of glutamate dehydrogenase, which in turn triggers the release of insulin from pancreatic cells. (EurekAlert!)
Recruitment Planned to Resume in AVANT International Phase III Trial in Adjuvant Colon Cancer May 23, 2006
Xeloda is contraindicated in patients who have a known hypersensitivity to 5-fluorouracil, and in patients with known dihydropyrimidine dehydrogenase (DPD) deficiency. Xeloda is contraindicated in patients with severe renal impairment. (PR Newswire)
Odessa boy has rare disorder May 21, 2006
Matt and Julie Riddle s 2-and-a-half year old son MacAlister has medium-chain acyl-CoA dehydrogenase (MCAD) deficiency, one of eight others with the same rare disorder in the state of Texas ... A seemingly healthy youngster, MacAlister has a rare disease called medium-chain acyl-CoA dehydrogenase (MCAD) deficiency. (Odessa American, TX)
Women Get Drunk and Addicted Easier Than Men May 18, 2006
And women have a lower activity level of an enzyme called alcohol dehydrogenase (ADH), which breaks down alcohol. Similar biological factors are at work in metabolizing illicit drugs. (Newsmax)
Patterns of addiction not gender-neutral Apr 27, 2006
" Alcohol dehydrogenase, a digestive enzyme that breaks down alcohol in the stomach, she adds, is also less active in women than in men. Complicating matters for women is the declining body water and estrogen levels that comes with age. "Apparently, (estrogen) levels are somewhat protective for women from puberty to probably mid-30s," says Foster. "(Estrogen) seems to have some protective influence in the way alcohol is metabolized and released from the body. " That women who are moderate to... (AZCentral -- Health)
Adherex Initiates Clinical Proof-Of-Mechanism Trial of Eniluracil Apr 26, 2006
Eniluracil, an oral dihydropyrimidine dehydrogenase (DPD) inhibitor, was previously under development by GlaxoSmithKline for oncology indications. STS, a drug from our specialty pharmaceuticals pipeline, protects against the disabling hearing loss that can often result from treatment with platinum-based chemotherapy drugs. (CCNMatthews Press Releases)
Alternatives To The Use Of Nitrate As A Fertiliser Apr 20, 2006
With respect to the activities of the GS (glutamine synthetase) and GDH (glutamate dehydrogenase) enzymes, responsible for the assimilation of ammonium, this substance is not modified in moderate concentrations in the pea but it is so in spinach. Regarding the main metabolic modifications, these take place in the roots in the case of the pea and in the leaves in the case of spinach. (Science Daily)
Measuring artery repair cells could become new heart disease test Mar 13, 2006
As an indicator of EPC cell levels, the new method uses measurements of the amount of a detoxification enzyme, known as aldehyde dehydrogenase (ALDH), which is produced in high amounts by EPCs. "Our studies have shown that using ALDH activity to determine the numbers of EPCs in a blood sample might be a better method for identifying and measuring EPC levels in patients with heart disease than currently used methods," said Duke cardiologist Thomas Povsic, M.D. Povsic presented the results of the... (EurekAlert!)
Hundreds of human genes still evolving Mar 9, 2006
Study links genetic changes to major events in human history. Updated: 4:50 p.m. ET March 8, 2006. (MSNBC -- Technology)
The Effect of Bisphosphonates on gene expression: GAPDH as a housekeeping or a new target gene? Mar 4, 2006
GAPDH (Glyceraldehyde-3-phosphate dehydrogenase) has been frequently considered as a constitutive housekeeping gene and used to normalize changes in specific gene expression. However, GAPDH has been shown to be up-regulated in many cancers and down-regulated by chemotherapic drugs. (BioMed Central)
Heard about molecular computers? Feb 26, 2006
The researchers used two enzymes, glucose dehydrogenase (GDH) and horseradish peroxidase (HRP), to trigger two interconnected chemical reactions, the online edition of New Scientist reported. According to the report, enzymes are already widely used to assist calculations. (India Times)
Enzyme computer could live in human body, Israeli scientist says Feb 25, 2006
The researchers used two enzymes - glucose dehydrogenase (GDH) and horseradish peroxidase (HRP) - to trigger two interconnected chemical reactions, the report said. Two chemical components - hydrogen peroxide and glucose - were used to represent input values (A and B), it explained. (People's Daily Online, China)
Drink and the modern girl Jan 15, 2006
This may be because women have lower levels of alcohol dehydrogenase (ADH), an enzyme involved in the metabolism of alcohol. " And according to the spokesman, the medical profession faces an uphill battle: "Alcohol advertising is now targeted at women. (The Independent, UK)
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