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Kosan's motilin agonist compound, KOS-2187, licensed to Pfizer, is in a Phase 1 trial in gastroesophageal reflux disease (GERD) ... Kosan's actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of these risks and uncertainties, which include, without limitation, risks related to the uncertain progress and results of Kosan's preclinical and clinical testing, including the risks that studies and trials may not... (PR Newswire)
Study Finds Potential Cause of Age-Related Macular Degeneration Mar 19, 2008
Instead, a Slit2 molecular agonist (that is, a molecular mimic) would need to be developed and tested in humans -- a process that could take a decade or more before arriving in the clinic, he said. AMD is the leading cause of blindness in Americans over the age of 55, according to the American Macular Degeneration Association, affecting more than 10 million individuals. (MEDLINEplus)
M's Science and Eisai Sign Option Agreement for Sigma Agonist SA4503 Mar 15, 2008
New 2007Annual Reports. 2001-2008 The Japan Corporate News Network (JCN) K.K.. (JCN Network, Japan)
ConjuChem Initiates Phase II Study of PC-DAC(TM):Exendin-4 Feb 20, 2008
Exendin-4, like Glucagon-like peptide-1 (GLP-1), is an insulinotropic peptide and an agonist for the GLP-1 receptor. Exendin-4 decreases glucagon and increases insulin secretion in a glucose-dependent manner. (Canada Newswire)
Athersys to Host Fourth Quarter 2007 Results Call Feb 15, 2008
The company's lead product candidate, ATHX-105, is an oral, selective 5HT2c receptor agonist in clinical development for the treatment of obesity. The company is developing other orally active pharmaceutical product candidates for the treatment of metabolic and central nervous system disorders, utilizing proprietary technologies, including Random Activation of Gene Expression (RAGE). (Primezone Releases)
AEterna Zentaris Reports First Patients Treated with Anti-Cancer Compound AEZS-108 in Phase 2 Trial in Ovarian and Endometrial Cancers Feb 12, 2008
QUEBEC CITY, Feb. 12 /CNW Telbec/ - AEterna Zentaris Inc. (NASDAQ: AEZS; TSX: AEZ), a global biopharmaceutical company focused on endocrine therapy and oncology, today reported that dosing of AEZS-108, a luteinizing hormone-releasing hormone (LHRH) agonist linked to doxorubicin, has commenced in its Phase 2 trial in gynaecological cancers for which patient enrolment had begun in December 2007 ... D., President and CEO of AEterna Zentaris commented, "We are excited to have started dosing patients... (Canada Newswire)
Labopharm Reports Positive Results for Phase III Study on Once-daily Trazodone Feb 8, 2008
About Trazodone Trazodone is an atypical anti-depressant that acts as a dual serotonin agonist and serotonin reuptake inhibitor (SARI). Trazodone appears to increase serotonin activity via three mechanisms: the activation of neuronal serotonin receptors; the inhibition at the neuronal serotonin feedback system which regulates the action of serotonin; and the inhibition of the re-uptake of serotonin. (Canada Newswire)
Anadys Pharmaceuticals to Present at the BIO CEO & Investor Conference Feb 6, 2008
The Company is developing ANA598, a small-molecule, non-nucleoside inhibitor of the NS5B polymerase for the treatment of chronic hepatitis C and ANA773, an oral TLR7 agonist prodrug for cancer. Safe Harbor Statement Statements in this press release that are not strictly historical in nature constitute "forward-looking statements." Such statements include, but are not limited to, references to Anadys' strategy, development programs, and ability to develop novel medicines in the areas of hepatitis... (PR Newswire)
'I lost 35,000'Patients claim drug led to gambling Feb 4, 2008
BI said it was company policy not to comment on litigation but they said it was, "the first pharmaceutical company... to add information about reports of pathological gambling associated with patients", using Mirapex and other dopamine agonists. BI added that, "pathological gambling may also be both part of the disease itself and potentially related to all dopamine agonists," as well as other treatments for Parkinson's such as levidopa ... Mirapex and other similar drugs which are called... (BBC News -- Health)
Johor steps up foodstuff inspection Feb 1, 2008
"We have also sent 22 samples for beta agonist test but the result has yet to be finalised,'' he told a press conference at his office here on Friday. He said imported products such as fruits, mushroom, wax duck and seaweed would be tested for pesticides, colouring, preservative and heavy metal substances. Dr Marzukhi said his officers had seized 620 can foods worth some RM78,000 from these premises. "The canned foods seized were dented, expired or found to have labelling problems and were not... (The Star Online, Malaysia)
Experimental Weight-loss Drug Cuts Appetite, Burns More Energy, Study Suggests Jan 11, 2008
"The ingredient responsible stimulates cannabinoid receptors. When you block the cannabinoid system with an antagonist like taranabant, you suppress appetite." However, the drug, developed by Merck, also comes with an increased risk of adverse side effects at higher doses, the study shows, including mild to moderate gastrointestinal and psychiatric effects. The first proof of concept that so-called cannabinoid 1 receptor (CB1R) inverse agonists might offer an obesity therapy came from studies of... (Science Daily)
Ministry to ensure safe food for CNY Jan 11, 2008
For domestic products, inspections will target meat for banned substances such as beta agonist, expired food products and labelling. Any suspected food product would be seized, he said. (The Star Online, Malaysia)
New Treatment Mechanisms For Schizophrenia Jan 10, 2008
D., lead author on this project, comments, "While treating patients with receptor agonists can be highly effective therapy, drugs that increase the action of the transmitter that activates the same receptor have traditionally been very effective with fewer side effects than chronic agonist treatment." He adds, "These data support the conclusion that NAAG peptidase inhibitors represent a breakthrough in the discovery of a completely novel means of adjunct therapy for schizophrenia that is... (Science Daily)
Arena Pharmaceuticals Announces APD668 Initial Clinical Study Results Suggest Glucose-Dependent Insulinotropic Receptors May Improve Glucose Control in Patients With Type 2 Diabetes Jan 8, 2008
Ortho-McNeil to Continue Investigation of GDIR Agonists Under its Partnership with Arena SAN DIEGO, Jan. 7 /PRNewswire-FirstCall/ -- Arena Pharmaceuticals, Inc. (Nasdaq: ) announced today that initial clinical study results for APD668, an oral drug candidate discovered by Arena and being investigated for the treatment of type 2 diabetes under a partnership with Ortho-McNeil Pharmaceutical, Inc., suggest that Glucose-Dependent Insulinotropic Receptors, or GDIRs, may improve glucose control in... (PR Newswire)
Taisho to Give Pfizer Overseas Rights for Schizophrenia Drug Candidate Jan 7, 2008
said Monday that it will grant U.S. drug giant Pfizer Inc. exclusive rights to develop and sell overseas TS-032, a new drug candidate developed by Taisho to treat schizophrenia (JCN Network, Japan)
Chua highly experienced Jan 2, 2008
GETTING pig farmers to sign a loyalty pledge to not use illegal substances, including beta agonist, on their livestock. He also worked on moves to cut down red tape when poor Malaysians applied for financial help through the ministrys Medical Aid Fund. (The Star Online, Malaysia -- News)
Hemispherx's CFS Clinical Programs Reviewed in European Community Dec 28, 2007
The UK report estimates that between 26,865 and 53,729 people in England and Wales, respectively, are ``severely affected'' with CFS. It recognizes Ampligen(r), an experimental therapeutic, as a new class of toll-like receptor 3 agonist drugs that would, if licensed, be the first pharmaceutical treatment for CFS.. During the 2008 calendar year Hemispherx plans to begin the commercial application process for introducing Ampligen(r) as a CFS therapeutic in the European Community. (Primezone Releases)
ARYx Therapeutics Provides Update on Product Development -- Reports Results for 2007 Third Quarter Dec 20, 2007
A potent agonist of 5-HT4 receptors which exist throughout the GI tract regulating gastric emptying and the motility of food through the intestines, ATI-7505 is engineered to maintain the efficacy of cisapride, a drug that reached peak sales of $1. 0 billion a year prior to being withdrawn from the market in 2000 due to life-threatening cardiac toxicities. (BusinessWire)
Intensive Care Quality Of Sleep Improved By New Drug, Reports Study Dec 15, 2007
14, 2007) A new sedative drug has been shown to improve the sleep quality and comfort levels of intensive care patients, compared to the most commonly-used medication, according to research published in the journal JAMA.. US and UK researchers compared the effects of the new drug dexmedetomidine with the commonly used sedative lorazepam, both of which reduce the pain and anxiety experienced by mechanically ventilated ICU patients and which help them to tolerate invasive procedures such as the... (Science Daily)
Athersys Commences Trading On NASDAQ Capital Market Dec 12, 2007 Ligand Presents Positive LGD-4665 Phase I Clinical Trial Results at the American Society of Hematology Annual Meeting (ASH) Dec 9, 2007 Kosan Presents Updated Data on Hsp90 Inhibitor, Tanespimycin, in Multiple Myeloma at Ash Dec 9, 2007 Parkinson's drugs 'made me gambler and gay sex fiend' Dec 9, 2007 Hemispherx Biopharma Receives Notice of Incomplete New Drug Application (NDA) Dec 8, 2007 Agonist Singer Recalls Painful Time On 'Canadian Idol'; Plus Philip Anselmo & More News That Rules, In Metal File Dec 8, 2007 Bionovo Describes a New Class of Therapeutic Compounds Nov 30, 2007 Eltrombopag and Chronic Idiopathic Thrombocytopenic Purpura Nov 29, 2007 Eltrombopag for Thrombocytopenia in Cirrhosis Nov 29, 2007 Immune Thrombocytopenic Purpura — From Agony to Agonist Nov 29, 2007 Glaxo confident as FDA probes asthma drugs in kids Nov 27, 2007 FDA approves ABILIFY(R) (aripiprazole) as the first medication for add-on treatment of MDD Nov 21, 2007 Sosei and Vectura Announce Start of Phase II Studies of QVA149 for the Treatment of COPD Nov 15, 2007 Karo Bio Initiates Phase IIb Clinical Study With KB2115 Nov 14, 2007 Prostate Cancer Death Risk Higher In Obese Or Overweight Men Nov 14, 2007 Athersys Reports Third Quarter 2007 Financial Results Nov 14, 2007 Brain Chemicals Involved In Aggression Identified: May Lead To New Treatments Nov 8, 2007 US FDA approves ABILIFY for adolescent patients with schizophrenia Nov 7, 2007 Attenuation of NASH by stimulation of free fatty acid metabolism Oct 27, 2007 Kosan to Reacquire Epothilone Program From Roche Oct 26, 2007 Fragile: handle with care Oct 25, 2007 Findings Could Lead To New Therapy For Spinal Cord Injury-induced Spasticity And Rigidity Oct 19, 2007 MediciNova Reports Phase IIa Clinical Study Results for MN-305, a Treatment for Insomnia Oct 19, 2007 How does the opioid system control pain, reward and addictive behavior? Oct 15, 2007 The endocannabinoids: Functional roles and therapeutic opportunities Oct 15, 2007 Karo Bio Has Presented Positive KB2115 Phase II Data at Two International Scientific Congresses Oct 8, 2007 Pharmos Receives Notice Related to Nasdaq Minimum Bid Price Rule Sep 29, 2007 Paramount BioSciences Appoints Business Development Vice President Sep 26, 2007 Labopharm completes enrolment for Phase III clinical study for its once-daily trazodone antidepressant drug Sep 25, 2007 Fentora Cancer Pain Drug Linked To Deaths Sep 15, 2007 Diabetes Drugs' Potential Adverse Side Effect Explained Sep 14, 2007 Diesel-Exhaust Inhalation in Men with Coronary Disease Sep 13, 2007 A Faster Class Of Antidepressants Sep 12, 2007 Japan's National Institute of Infectious Diseases Widens Research On Hemispherx's Ampligen, An Immune Enhancer, Co-Administered With a Vaccine in AIDS Research Sep 10, 2007 High hopes for new schizophrenia drugs Sep 6, 2007 Speedy drugs for depression Sep 6, 2007 Experimental Antidepressants Offer Faster Relief Sep 6, 2007 GTx, Inc. (GTXI) Chief Executive Officer to Ring the NASDAQ Stock Market Opening Bell Sep 1, 2007 Eligard(R) six-month formulation successfully completes European approval procedure Aug 31, 2007 Tikvah Therapeutics Signs Agreement to Develop and Commercialize LY156735, a Second Generation Melatonin Agonist, for Circadian Rhythm and Sleep Disorders Aug 29, 2007 Anadys Pharmaceuticals Appoints Steve Worland, Ph.D. as President and Chief Executive Officer Aug 25, 2007 MediciNova Reports Phase Ib Clinical Study Results for MN-221, a Novel Treatment for Preterm Labor Aug 17, 2007 Battle Of The Bulge: What Controls How Much We Eat? Aug 15, 2007 Setbacks for two Wyeth drugs, including one with partner ViroPharma Aug 13, 2007 JRRD releases volume 44, issue 3 Aug 2, 2007 Reducing inflammation plays key role in type 1 diabetes therapy Aug 1, 2007 Development Discontinued for ANA975, an Early Stage Compound for Treatment of Hepatitis C Virus Infection Jul 27, 2007 Study finds COPD patients taking inhaled steroids are at greater risk for severe pneumonia Jul 16, 2007 Slowing muscle degeneration in muscular dystrophy Jul 13, 2007 New Approaches To Endometriosis Treatment: Mouse Experiments Point The Way Jul 10, 2007 AstraZeneca announces SYMBICORT is now available in the US Jul 9, 2007 Phase IIIb Clinical Data Validate the Overall and Cardiovascular Safety Profile of Cycloset(TM) (A Quick Release Formulation of Bromocriptine Mesylate) in Patients with Type 2 Diabetes Jun 24, 2007 TheraQuest Initiates GMP Manufacturing of Abuse Deterrent Sustained Release TQ-1015 Opioid: Novel Kappa Mechanism Reverses Morphine Tolerance Jun 23, 2007 Behemoth: Too Dangerous For Poland? Plus Agonist, Machine Head And More News That Rules, In Metal File Jun 22, 2007 Shire Receives Approvable Letter From FDA for INTUNIV(TM) (guanfacine) Extended Release, a Nonstimulant for the Treatment of ADHD Jun 21, 2007 100 days of ineptitude Jun 19, 2007 Minister: Pig farmers have pledged not to use banned substances Jun 18, 2007 Levodopa/Carbidopa for Parkinson's Jun 15, 2007 Q&A: chemical castration Jun 14, 2007 Labopharm Initiates Phase III Clinical Study for Once-Daily Formulation of Trazodone Jun 7, 2007 The zero effect Jun 7, 2007 The Pregnant Asthmatic Guide Jun 6, 2007 Abilify sNDA for pediatric patients with schizophrenia accepted for priority FDA review Jun 6, 2007 Pfizer Inc UK Regulatory Announcement: New Data Evaluating SUTENT, CP-751,871 and Axitinib in Patients with Non-Small Cell Lung Cancer Jun 4, 2007 » Concert listings May 31, 2007
The company's lead product candidate, ATHX-105, is an oral, selective 5HT2c receptor agonist in Phase I clinical trials for the treatment of obesity. The company is also developing other orally active pharmaceutical product candidates for the treatment of metabolic and central nervous system disorders, utilizing proprietary technologies, including Random Activation of Gene Expression (RAGE). (Primezone Releases)
* Taiwan News Quick Take Dec 11, 2007
Dopamine agonist alert ... Dopamine agonists routinely used to alleviate symptoms of the degenerative disease have been linked to compulsive behaviors such as pathological gambling. (Taipei Times, Taiwan -- World)
SAN DIEGO--()--Ligand Pharmaceuticals Incorporated (NASDAQ:LGND) today announced positive results from a Phase I clinical trial with LGD-4665 in a poster titled Single and Multiple Oral Doses of LGD-4665, a Small Molecule Thrombopoeitin Receptor Agonist, Increase Platelet Counts in Healthy Male Subjects, at the American Society of Hematology (ASH) 49th Annual Meeting, being held at the Georgia World Congress Center in Atlanta December 8-11, 2007 ... LGD-4665 is a highly selective full agonist... (BusinessWire)
Kosan's motilin agonist, KOS-2187, licensed to Pfizer, is in a Phase 1 safety trial, with plans to pursue development in gastroesophageal reflux disease (GERD). This press release contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995 (the "Act"). (PR Newswire)
Didier Jambart, a French defence ministry employee, has been suing for damages of 400,000 after being prescribed with dopamine agonist drugs in a case that is being closely studied by lawyers representing Parkinson's sufferers in Britain, the US and Canada ... Dopamine agonists, which mimic the mood chemical dopamine, are used in several branded drugs commonly prescribed for Parkinson's, a debilitating disease which affects some 120,000 people in Britain ... As soon as we saw him we knew... (Guardian Unlimited -- World)
The NDA filing rate does not affect ongoing vaccine enhancement programs with Ampligen(r), an experimental TLR3 agonist, or ongoing Treatment IND programs for CFS in the U.S.. About Hemispherx Biopharma. (Primezone Releases)
Agonist Singer Recalls Painful Time On 'Canadian Idol'; Plus Philip Anselmo & More News That Rules, In Metal File ... The Agonist (Photo: Century Media) ... It's November 20, and Alissa White-Gluz the comely singer for Canadian metalcore outfit the Agonist is in a hotel room in the middle of Colorado. (VHI.com -- Music News)
- Highly selective estrogen receptor beta agonists have promise for safer therapies in women's health - EMERYVILLE, Calif ... The paper, entitled "Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonist" provides details of the selective transcriptional activation of liquiritigenin to the estrogen receptor beta, highlights the advantages of an estrogen receptor beta targeted drug and discusses the isolation and structural identification of the pure chemical compound... (PR Newswire)
Methods We conducted a trial in which 118 adults with chronic ITP and platelet counts of less than 30,000 per cubic millimeter who had had relapses or whose platelet count was refractory to at least one standard treatment for ITP were randomly assigned to receive the oral thrombopoietin-receptor agonist eltrombopag (30, 50, or 75 mg daily) or placebo. The primary end point was a platelet count of 50,000 or more per cubic millimeter on day 43. (New England Journal of Medicine)
Background Eltrombopag is a new, orally active thrombopoietin-receptor agonist that stimulates thrombopoiesis. We evaluated its ability to increase platelet counts and facilitate treatment for hepatitis C virus (HCV) infection in patients with thrombocytopenia associated with HCV-related cirrhosis. (New England Journal of Medicine)
NEJM -- Immune Thrombocytopenic Purpura -- From Agony to Agonist ... Immune Thrombocytopenic Purpura From Agony to Agonist. (New England Journal of Medicine)
Serevent, a long-acting beta agonist used to ease breathing, is also included in Advair, Glaxo's biggest product with worldwide sales of 3. 3 billion pounds ($6. (Reuters.uk)
The first and only available dopamine partial agonist, ABILIFY is indicated as adjunctive treatment to antidepressant therapy in adults with major depressive disorder. Initially approved in November 2002, over 12. (EurekAlert! -- Business News)
QVA149 is a combination of NVA237, a once-daily long-acting muscarinic antagonist (LAMA) and indacaterol, a once-daily long-acting beta-2 agonist (LABA) ... Novartis is responsible for developing and commercializing NVA237 both as a monotherapy and in combination with indacaterol, its once daily, long acting beta 2 agonist, as QVA149. (PR Newswire)
KB2115 is a novel, selective, thyroid hormone agonist for treatment of dyslipidemia. Recently Karo Bio presented positive data from a first phase IIa study. (BusinessWire)
For the study, the researchers used data from a phase 3 trial involving 945 men with locally advanced prostated cancer who were enrolled between 1987 and 1992 and randomized to receive either radiation therapy and immediate hormone therapy (using goserelin, a GnRH agonist that stops the production of sex hormones), or radiation therapy followed by hormone therapy at recurrence. They were able to get initial height and weight data for 788 of the patients and follow them for 8 years. (Medical News Today)
During the period, the company initiated its Phase I clinical trial for ATHX-105, the company's oral selective 5HT2c receptor agonist for treating obesity ... In July 2007, Athersys initiated a Phase I clinical trial in the United Kingdom for ATHX-105, the company's oral, selective 5HT2c receptor agonist for treating obesity ... The company's lead product candidate, ATHX-105, is an oral, selective 5HT2c receptor agonist in Phase I clinical trials for the treatment of obesity. (Primezone Releases)
" More recently, de Boer and his colleagues have found that the transition from normal, adaptive aggressive behavior into abnormal forms that inflict harm and injury is due to functional, but not structural, changes in certain serotonin receptors in the brain. In animal studies, treatment with selective serotonin receptor agonist compounds has been found to restore the normal function of these receptors-and suppress aggressive behavior, including its escalated forms. These findings may one day... (Science Daily)
"We are extremely pleased that ABILIFY, the first available dopamine partial agonist, is approved for the treatment of pediatric patients (13 to 17 years of age) suffering from schizophrenia," said Tatsuo Higuchi, President and Representative Director, Otsuka Pharmaceutical Co., Ltd. "ABILIFY offers an effective new option to help treat this serious mental illness." ... The first and only available dopamine partial agonist, ABILIFY is indicated for the treatment of acute manic or mixed episodes... (EurekAlert! -- Business News)
The article describes how administration of a constitutive androstane receptor (CAR) agonist (TCPOBOP) can induce genes involved in fatty acid microsomal omega-oxidation and beta-oxidation pathways, resulting in a reduction in the occurrence of NASH in mice fed the methionine choline deficient (MCD) diet ... Reference: Baskin-Bey ES, Anan A, Isomoto H, Bronk SF, Gores GJ. Constitutive androstane receptor agonist, TCPOBOP, attenuates steatohepatitis in the methionine choline-deficient diet-fed... (EurekAlert!)
" The webcast is also being distributed over Thomson's Investor Distribution Network to both institutional and individual investors. Individual investors can listen to the call through Thomson's individual investor center at or by visiting any of the investor sites in Thomson's Individual Investor Network. Institutional investors can access the call via Thomson's password-protected event management site, StreetEvents, at . A telephonic replay will be available through November 2, 2007 by dialing... (PR Newswire)
However, there are other molecules available, called hormone agonists, which mimic the behaviour of hormones, and improve the bone strength. One such hormone agonist is relaxofine, which is similar to oestrogen ... The hormone agonist contributes marginally to the improvement of bone mass. (Express Pharma)
In work with rats, Martin Marsala, M.D., a professor in the Department of Anesthesiology at the University of California, San Diego (UCSD) School of Medicine, demonstrated that an AMPA receptor antagonist called NGX424 (tezampanel), being developed by TorreyPines Therapeutics, Inc., of La Jolla, California, is highly potent in suppressing spasticity and rigidity ... The most effective treatment for the spastic muscle condition -- which results in pain and tremendous spasms, even in those... (Science Daily)
MN-305 is a potent and highly-selective full agonist at the serotonin 5-HT1A receptor under development by MediciNova both for the treatment of insomnia, as well as for anxiety disorders such as Generalized Anxiety Disorder (GAD). MN-305 has been evaluated in an extensive preclinical toxicology program which showed no evidence of inducing genetic mutations, immune response or cancer. (Primezone Releases)
The mutant mice demonstrated increased levels of anxiety, and a depressive-like behavior these findings have important implications on the field of opioid research und uncover the therapeutic potential for delta-agonists in the treatment of mood disorders ... Opiate addicts, who mainly abuse the mu-opioid agonist heroin, present a high incidence of depressive disorders that seem to contribute to the maintenance of the addictive state ... Therefore, in addition to their potential analgesic... (EurekAlert!)
Activation of the CB2 receptor by a selective agonist also improved the neurological score ... Modulation of this system either by exogenous agonists specific for the CB2 receptors or possibly also by antagonists to the CB1 receptors may have therapeutic potential. (EurekAlert!)
KB2115 is a first in class, liver and receptor selective thyroid hormone receptor agonist, intended for the treatment of dyslipidemia. Karo Bio presented the first clinical phase II data demonstrating that profound blood lipid lowering may be achieved while avoiding cardiac and other side effects typically associated with non selective thyromimetics. (BusinessWire)
The Company's core proprietary technology platform focuses on discovery and development of synthetic cannabinoid compounds, especially CB2 receptor-selective (CB2-selective) agonists. PRS-639,058, the leading CB2-selective agonist, has demonstrated promising preclinical data in neuropathic pain. (Primezone Releases)
While at Pfizer, Mr. Jacks was instrumental in several high profile transactions including the 2006 acquisition of PowderMed, the 2005 acquisition of Vicuron, the 2005 in-license of the TLR9 agonist PF-3512676 from Coley, the 2004 acquisition of European rights to Campto from Sanofi-Aventis, and the 2003 in-license of the fluoroquinolone DK-507k from Daiichi. Mr. Jacks also guided the development of several late-stage internal products including Selzentry(tm), the recently approved,... (Primezone Releases)
"Our proprietary Contramid(R) controlled-release technology applied to trazodone has allowed us to develop a novel approach to treating major unipolar depression that addresses the related conditions of insomnia and agitation while providing the benefit of once-daily administration," said James R. Howard-Tripp, President and Chief Executive Officer, Labopharm Inc. "We are excited about the prospects for this novel approach to treating depression and are pleased to have completed enrolment for... (Canada Newswire)
Fentanyl is a potent analgesic and opioid agonist, like morphine, methadone, oxycodone, hydromorphone, oxymorphone, and has a similar abuse liability as these drugs. Although physicians should be aware of the potential for misuse when prescribing any drug, in the case of Fentora and other opioids they need to be extra careful because of the high potential for misuse, abuse, or diversion of these substances. (Medical News Today)
Drugs that are agonists of the receptor PPAR-gamma are used to treat individuals with diabetes ... In a new study, Ira Goldberg and colleagues at Columbia University, New York, outline a potential explanation for the adverse effects observed in a minority of patients being treated with PPAR-gamma agonists ... Administration of a PPAR-gamma agonist to these mice exacerbated their heart dysfunction. (Science Daily)
Six hours after exposure, vasomotor and fibrinolytic function were assessed by means of intraarterial agonist infusions. Results During both exposure sessions, the heart rate increased with exercise (P<0. (New England Journal of Medicine)
In their experiments, Lucas and colleagues tested in rats the effects of two such "serotonin receptor agonist" compounds, called RS 67333 and prucalopride, that target serotonin type-4 receptors ... Both of the serotonin receptor agonists strongly reduced this time of immobility, indicating an antidepressant action ... In further studies, the researchers found that only three days of treatment with the serotonin receptor agonists induced antidepressant-related changes in the brains of the... (Science Daily)
PHILADELPHIA, Sept. 10, 2007 (PRIME NEWSWIRE) -- Hemispherx Biopharma, Inc. (AMEX: - ) today announced that Japan's National Institute of Infectious Diseases (NIID) has extended its relationship with Hemispherx Biopharma to initiate research on the intranasal co-administration of NIID's HIV-1 vaccine with Hemispherx's experimental TLR3 agonist and immune enhancer, Ampligen(r) (Poly I; Poly C12U) ... As was previously disclosed this year, Japan's Ministry of Health, Labor and Welfare (MHLW)... (Primezone Releases)
First, current antipsychotics work by acting as antagonists at dopamine receptors, not by reducing the amount of dopamine. Second, the action of PCP was glutamate receptor antagonism, and the new drug described here acts as a glutamate receptor agonist ... It acts as an agonist at presynaptic receptors which results in a reduction in the amount of glutamate released presynaptically, thus effectively capping glutamate tone. (Nature News Service)
But the drugs called serotonin receptor agonists won't be replacing Paxil (paroxetine) soon ... The rodents that received an antidepressant were less sugar-shy than controls, and the ones that got the new serotonin receptor agonists regained their sweet tooth a week earlier than those given an SSRI. ... After three days, rats receiving serotonin receptor agonists showed signs of new neuron growth another indicator of antidepressant action 0000055C 2; whereas the SSRI-treated rats did not. (Nature News Service)
The new study looked at a new class of drugs known as serotonin4 (5-HT4) receptor agonists, which have a more specific effect ... For the study, the researchers tested two serotonin receptor agonist compounds, called RS 67333 and prucalopride, in rats, comparing the drugs against the action of Celexa ... In one test, the researchers found that one of the serotonin receptor agonists took effect after only three days and completely erased the depressive symptoms after one week. (Health-Finder)
GTx is also developing two other product candidates, GTx-838, another GTx SARM, for the treatment of sarcopenia, and GTx-878, an estrogen receptor beta agonist for the treatment of benign prostatic hyperplasia and chronic prostatitis. GTx is planning to file an Investigational New Drug application (IND) with the FDA for GTx-838 by year end 2007 and to file an IND for GTx-878 during 2008. (Primezone Releases)
About Eligard Eligard, a palliative treatment for advanced prostate cancer, incorporates a luteinizing hormone-releasing hormone agonist, or LHRH agonist, known as leuprolide acetate with QLT USA's proprietary Atrigel(R) Delivery System. The Atrigel technology allows for sustained delivery of leuprolide acetate for periods ranging from one to six months. (PR Newswire)
Pilot clinical studies, conducted by P2D in response to the unique receptor binding profile of LY156735, suggest that improved efficacy in standard measures of sleep may be possible compared to another melatonin agonist ... Tikvah's pipeline already includes Phase II compounds such as TIK-201, an agent initially targeted to treat neurodegenerative diseases; TIK-101 and other NMDA receptor agonists for treatment of a variety of anxiety disorders and chronic pain; and multiple other products under... (Primezone Releases)
The Company is developing ANA598, a small-molecule, non-nucleoside inhibitor of the NS5b polymerase for the treatment of HCV and ANA773, an oral TLR7 agonist prodrug for cancer. Safe Harbor Statement Statements in this press release that are not strictly historical in nature constitute "forward-looking statements." Such statements include, but are not limited to, references to the expected timing and planned development activities for ANA598 and ANA773. (PR Newswire)
MN-221 is a highly-selective beta2-adrenergic receptor agonist under development by MediciNova for the treatment of status asthmaticus and preterm labor. Preclinical testing in vitro and in vivo shows MN-221 to be more selective for the beta2-adrenergic receptor than other beta2-adrenergic receptor agonists used to treat these conditions. (Primezone Releases)
Administration of a PPAR-alpha agonist into the hypothalamus increased the amount mice lacking FAS specifically in the beta-islet cells and in the hypothalamus ate but did not increase the amount normal mice ate. This study therefore identifies FAS-mediated activation of PPAR-alpha as a molecular pathway controlling feeding behavior in mice. (Science Daily)
Gary L. Stiles, executive vice president and chief medical officer at Wyeth Pharmaceuticals, said the drug, a partial dopamine agonist, would be "a new treatment approach for patients where maintaining stability is challenged by the metabolic consequences frequently encountered with long-term therapy.". Solvay Pharmaceuticals Inc. is based in Marietta, Ga. (Philadelphia Business Journal, PA)
A smooth stair descent requires good coordination of the agonist and antagonist muscles surrounding the joint during the descent. Since both muscle strength and kinesthetic feedback diminish with age, older individuals may use a different control strategy to descend stairs than younger individuals do. (EurekAlert!)
To test this hypothesis, the authors administered a cocktail of three separate agents (rapamycin plus agonist IL-2- and antagonist-type, mutant IL-15-related Ig fusion proteins) in a NOD (non-obese diabetes) mouse model of type 1 diabetes. The therapy regimen, which included two novel immunoglobulin-fusion proteins, was aimed at both increasing tolerance and decreasing inflammation. (EurekAlert!)
"However, we remain optimistic that TLR7 agonists offer therapeutic potential as effective immunomodulators in multiple disease areas, albeit using alternative dosing schedules, and our plans to develop ANA773 for cancer treatment continue unabated," Dr. Fritz said. Anadys continues its development of ANA773, another TLR7 agonist prodrug distinct from ANA975, and expects to file an IND by the end of 2007 ... Small-molecule TLR7 agonists have been shown to have broad antiviral and anticancer... (PR Newswire)
In an accompanying editorial, Mark Woodhead, D.M, of Manchester (U.K.) Royal Infirmary, wrote that this report confirms secondary findings from a prospective, placebo-controlled study of an inhaled corticosteroid with long-acting -agonist that was recently published. Given that this earlier study was not designed to analyze pneumonia frequency, its small size and high drop-out rate, he suggested, might lead a reader to reasonably conclude that its pneumonia findings were spurious. (EurekAlert!)
Corticotrophin releasing factor 2 receptor agonist treatment significantly slows disease progression in mdx mice Richard T Hinkle , Frank R Lefever , Elizabeth T Dolan , Deborah L Reichart , Jefferey A Dietrich , Kathryn E Gropp , Robert I Thacker , Jeffrey P Demuth , Paula J Stevens , Xiaoyan A Qu , Alex R Varbanov , Feng Wang and Robert J Isfort ... Using the mdx mouse model, we have evaluated the effect that corticotrophin releasing factor 2 receptor (CRF2R) agonist treatment has on diaphragm... (BioMed Central)
They created an experimental model of endometriosis in nude mice in order to test whether dopamine agonists, much used in other infertility treatment such as the prevention of ovarian hyper-stimulation syndrome, could be a new strategy for inhibiting endometrial lesions. "We know that dopamine agonists are a safe treatment, and that they have been used for many years in order to stop breastfeeding, for example, without any major side effects", says Dr. Novella-Maestre, "so we decided to see what... (Science Daily)
Administered twice daily, SYMBICORT is a combination of two proven asthma medications budesonide, an inhaled corticosteroid (ICS), and formoterol, a rapid and long-acting beta2-agonist (LABA) ... Long-acting beta2-adrenergic agonists may increase the risk of asthma-related death ... Data from a large placebo-controlled US study that compared the safety of another long-acting beta2-adrenergic agonist (salmeterol) or placebo added to usual asthma therapy showed an increase in asthma-related... (EurekAlert! -- Business News)
About Cycloset(TM) (A Quick Release Formulation of Bromocriptine Mesylate) Cycloset(TM) is an oral, quick-release formulation of bromocriptine, a centrally-acting dopamine D2 receptor agonist. When given as a single timed (morning) daily dose, Cycloset(TM) is believed to act on circadian neuronal activities within the hypothalamus to reset abnormally elevated hypothalamic drive for increased plasma glucose, triglyceride, and free fatty acid levels in fasting and postprandial states in insulin... (PR Newswire)
June 22 /PRNewswire/ -- TheraQuest Biosciences, a development stage pain management company today announced that it has begun GMP manufacturing of TQ-1015, its proprietary abuse deterrent, sustained release opioid agonist. An U.S. IND application is scheduled for January, 2008. (PR Newswire)
Plus Agonist, Machine Head And More News That Rules, In Metal File ... Plus Agonist, Machine Head And More News That Rules, In Metal File Plus: Gwar plan more gut-spilling gigs; 'Get Thrashed' documentary wins Grand Prize at film fest ... " In other words, it's gonna rock. ... Thunderous Los Angeles metal duo Big Business have announced that they'll open for Tool on 14 dates starting Sunday in Hamilton, Ontario, and ending July 18 at a previously unannounced Tool show in Holmdel, New Jersey. ...... (VHI.com -- Music News)
BASINGSTOKE, England and PHILADELPHIA, Pennsylvania, June 21 /PRNewswire-FirstCall/ -- Shire plc (LSE: SHP, NASDAQ: SHPGY, TSX: SHQ) announced today that it has received an approvable letter from the US Food and Drug Administration (FDA) for INTUNIV (guanfacine) extended release tablets (previously referred to as SPD503), a nonstimulant selective alpha-2A-receptor agonist, which has been studied in children and adolescents with Attention-Deficit/Hyperactivity Disorder (ADHD) ... The selective... (PR Newswire)
" actor Harvey Keitel asks as he wanders the ruins on an ancient battlefield. World-weary chorus, oracle and everyman, Keitel is a solitary agonist in Irish artist James Coleman's 45-minute film installation, Retake With Evidence (2007). Keitel is unsurprised when no answer is forthcoming, knowing it is futile to interrogate the broken statuary or the skulls in the dirt. "I should not have come here," he opines. You and me both, I think, wishing for some of Keitel's stoicism and built-in... (Guardian Unlimited)
PUTRAJAYA: Almost all pig farmers nationwide have signed the loyalty pledge not to use beta agonist and other illegal growth enhancing substances on their livestock ... He said the response from the pig farmers had been encouraging with no new cases of beta agonist detected in pork at the abattoirs ... He said the use of beta agonist among pig farmers had stopped, as the substance was a banned item and using it was not cost effective. (The Star Online, Malaysia)
Another option is prescribing a dopamine agonist, which is less effective than levodopa, but good for new and/or mild cases. Doctors believe that prescribing the least amount of levodopa/carbidopa, saving the drug combination for later stages of the disease, and using milder drugs in the beginning of the disease course can allow patients to benefit from levodopa/carbidopa's positive aspects while warding off its side-effects and eventual ineffectiveness. (Suite101.com)
One of the most effective ways to turn off testosterone is to use a chemical called a GnRH agonist, which can be injected or given as a nasal spray. This overstimulates the pituitary gland and stops it producing a hormone which regulates testosterone production. (Guardian Unlimited -- UK)
About Trazodone Trazodone is an atypical anti-depressant that acts as a dual serotonin agonist and serotonin reuptake inhibitor (SARI). Trazodone appears to increase serotonin activity via three mechanisms: the activation of neuronal serotonin receptors; the inhibition at the neuronal serotonin receptors of the feedback system which regulates the action of serotonin; and the inhibition of the re-uptake of serotonin. (Canada Newswire)
The trade name drug Cytotec, prostaglandin agonist for gastric ulcer, was chosen because it can increase mucin production ... One of the downstream signals of VEGF is PI (3) K. Using a prostaglandin agonist to stimulate glycophorin A dimmer will increase mucin secretion. (Nature News Service)
The second group of anti- asthma medications are the short acting beta agonist drugs such as albuterol or terbutaline ... Many studies have shown no increased risk for major birth defects among b2 agonists users compared to those who did not use them and thus they are mostly given the O.K during pregnancy ... The next set of medications are the longer acting beta agonists like salmetrol, where Bracken and colleagues reported no increased risk for preterm delivery in pregnancies exposed to... (Suite101.com)
The first and only available dopamine partial agonist, ABILIFY is indicated for the short- and long-term treatment of schizophrenia including maintaining stability in adults who had been symptomatically stable on other antipsychotic medications for periods of three months or longer and observed for relapse during a period of up to 26 weeks. ABILIFY is also indicated for the treatment of acute manic and mixed episodes associated with Bipolar I Disorder, and for maintaining efficacy in adults with... (EurekAlert! -- Business News)
PF-676 is a toll-like receptor (TLR) 9 agonist, which stimulates dendritic cells to trigger a cytokine and chemokine cascade and subsequent T-cell activation. Two phase III clinical trials of PF-676, one with paclitaxel plus carboplatin, the other with gemcitibine plus cisplatin, began recruiting patients in November 2005 and completed accrual in April 2007. (BusinessWire)
June 17 - God Forbid, the Agonist, Pullout Method, Mind Over Malice, 8 Weeks Dead, A Perfect Honesty, Masochist, Pristina, Enter the Gates, Deadwait. $12 advance. (CTNow.com)
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