Dylan Carney To Be Featured On ESPN Special Jul 15, 2008
He coauthored papers in journals such as Nature and the PNAS, and in 2006 he presented his work at the Abcam Chromatin Structure and Function Conference in the Dominican Republic. He also studied abroad in South Africa and Mexico. (Gostanford.com)
Genome communication Jun 27, 2008
When it is time for genes to be expressed, a section of chromatin is unwound and the DNA for that particular gene is made available to the machinery that transcribes DNA to RNA. Once the process is finished, the DNA is neatly folded back into the chromatin structure until needed again. Different parts of the genome can interact by direct contact or through intermediaries that can be proteins or RNA sequences. (EurekAlert!)
Mom's High Fat Diet During Pregnancy May Be Key To Child's Weight Issues Jun 23, 2008
Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome. Journal of Molecular Endocrinology, 2008; In press DOI. (Science Daily)
Student-Athletes Honored At Annual Spring Awards Luncheon Jun 13, 2008
Has done lab work to characterize the role of chromatin structure on somatic V(D)J recombination during development of the human immune system. Graduated with distinction and received a Class of 2007 Award of Excellence. (Gostanford.com)
'PLoS ONE' STUDY: A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice Jun 4, 2008
Gene expression profiling suggests that both CR and resveratrol may retard some aspects of aging through alterations in chromatin structure and transcription. Resveratrol, at doses that can be readily achieved in humans, fulfills the definition of a dietary compound that mimics some aspects of CR.. (USA Today -- Tech)
Dylan Carney Named Finalist For The Walter Byers Postgraduate Scholarship Apr 23, 2008
He has coauthored papers in journals such as Nature and the PNAS, and in 2006 he presented his work at the Abcam Chromatin Structure and Function Conference in the Dominican Republic. He has also studied abroad in South Africa and Mexico. (Gostanford.com)
New Technique Yields More Detailed Picture Of Chromatin Structure Apr 21, 2008
This allowed the antibodies to penetrate more deeply into the chromatin structure, and boosted the number of gold particles adhering to regions of interest ... We are interested in chromatin structure, so our targets are mostly chromatin-bound proteins, Kireev said. (Science Daily)
Mechanism for regulation of growth and differentiation of adult muscle stem cells is revealed Dec 8, 2007
Although the signaling pathways controlling muscle regeneration are fairly well known, how these signals lead to altered chromatin structure remains undiscovered. A group of scientists at the Burnham Institute for Medical Research in La Jolla, CA, analyzed the mechanism by which certain cellular signaling cues cause epigenetic modifications when released within the regenerative microenvironment, thus controlling the expression of genes that regulate growth and differentiation of muscle stem... (EurekAlert!)
Compound of milk thistle shows anti-cancer effects Nov 18, 2007
In addition, they demonstrated that silibinin mediates anti-liver cancer effects by (1) reduced cancer cell proliferation and cell cycle progression; (2) enhanced programmed death of cancer cells; and (3) altered chromatin structure of the cancer cells. Their research results indicate that silibinin can be used to prevent the development of liver cancer, one of the most common cancers worldwide. (News-Medical.net)
Scientific Evidence Of The Significant Anti-cancer Effect Of Milk Thistle Nov 16, 2007
altered chromatin structure of the cancer cells. Their research results indicate that silibinin can be used to prevent the development of liver cancer, one of the most common cancers worldwide. (Science Daily)
Poly-G/poly-C tracts in the genomes of Caenorhabditis Nov 7, 2007
The abundance and genomic distribution of G/C tracts in C. elegans, the effect of G/C tracts on regional transcription levels, and the lack of positional conservation of G/C tracts in C. briggsae suggest a role for G/C tracts in chromatin structure but not in the transcriptional regulation of specific genes. The complete article is available as a. (BioMed Central)
Cell Pathway, Disease Linked To Histone Action Oct 29, 2007
One thing we know for sure is that modifying histones is very important to chromatin structure and function, he said. Chromatin is the DNA and protein mixture that makes up chromosomes, the threadlike structures inside cells that are necessary for reproduction. (Science Daily)
Regulating Embryonic Stem Cell Self-renewal Oct 22, 2007
Dr. Ng and colleagues investigated how modifications to chromatin structure influence gene transcription and ES cell function. The researchers found that Jmjd1a and Jmjd2c, which encode enzymes that demethylate histone H3 lysine 9, regulate self-renewal in mouse ES cells: Depletion of Jmjd1a and Jmjd2c promoted differentiation, at the expense of self-renewal. (Science Daily)
Human Genome Yields Up More Secrets Jun 14, 2007
For example, a team at the University of Virginia has found that the degree to which DNA is bound within the chromosome's chromatin structure strongly influences whether that gene can express, or produce, a protein. While smaller studies have hinted at that before, "this genome-wide survey really shows that these factors are beautifully coordinated," lead researcher Dr. Anindya Dutta, a professor of molecular genetics at the university, told HealthDay. (Forbes)
First pages of regulation "Encyclopedia" Jun 14, 2007
In general, many of the findings regarding chromatin structure, histone modifications, and transcription have been suggested by previous studies, Schadt said, but the size and depth of the ENCODE analyses provide "a tour-de-force, integrated analysis of all that information and [show] how an extensive annotation of the human genome might work," he told Nature. The consortium next combined new data from various types of analyses -- including transcription, DNA replication timing, chromatin... (The Scientist)
UCI awarded $3.5 million for stem cell research UCI, Feb. 16 Feb 17, 2007
Kyoko Yokomori, associate professor of biological chemistry, was awarded $623,500 to study the chromatin structure formed at DNA sequences linked to a form of muscular dystrophy. She plans to develop human embryonic stem cells associated with the disorder and compare them to normal human embryonic stem cells during skeletal muscle differentiation. (University of California Newswire, CA)
Prediction of highly expressed genes in microbes based on chromatin accessibility Feb 13, 2007
It is well known that gene expression is dependent on chromatin structure in eukaryotes and it is likely that chromatin can play a role in bacterial gene expression as well. Here, we use a nucleosomal position preference measure of anisotropic DNA flexibility to predict highly expressed genes in microbial genomes. (BioMed Central)
Epigenetics mark regulatory elements Feb 6, 2007
"That's actually quite interesting that you end up having the same type of chromatin structure at promoters in all sorts of different organisms," said of the University of Massachusetts in Worcester, who was not involved in the study. The researchers then analyzed histone modifications in regions likely to be enhancers and found that they displayed monomethylation of the same lysine residue. (The Scientist)
Regulating The Nuclear Architecture Of The Cell Dec 14, 2006
Heterochromatin is typically found at the ends of a chromosome, where it abuts the telomeres chromatin structures best known for limiting, by their diminishing length, how many times a cell can replicate. Heterochromatin also flanks the centromere in the central region of the chromosome, the chromatin structure that plays a crucial role in chromosome segregation during cell division. (Science Daily)
Finding A Cure For Cancer: The Holy Grail Of Science Nov 25, 2006
People currently start to think not only about DNA damage and mutations, but also about epigenetic disturbances, for example alterations in chromatin structure, which may affect gene expression, said Friedl. "We came up with the idea of using an ion microbeam in 1999 but it has taken us a long time to make our idea happen". (Science Daily)
Genome-wide mapping of ORC and Mcm2p binding sites on tiling arrays and identification of essential ARS consensus sequences in S. cerevisiae Oct 27, 2006
Although local chromatin structure and function influences origin activity, the exact mechanisms remain poorly understood. A key to understanding the exact features of chromatin that impinge on replication origin function is to define the precise locations of the DNA sequences that control origin function. (BioMed Central)
RNA interference is inherited Jul 22, 2006
It's not yet clear exactly how the paramutation information is transmitted through meiosis, Chandler said, but two general possibilities exist: Meiosis could transmit the amplified RNA molecules themselves, or it could pass on the RNA-programmed chromatin structure, which would then allow the RNA to be made again ... M. Stam et al., "Differential chromatin structure within a tandem array 100 kb upstream of the maize b1 locus is associated with paramutation," Genes opment, August 1, 2002. (The Scientist)
Oxidation drives SNPs, recombination May 3, 2006
Evidence from other studies has suggested that "factors like chromatin structure or transcription status affect 8-oxoG density in different genomic regions," he said. Melissa Lee Phillips. (The Scientist)
Clues to what guides ES cells Apr 21, 2006
B.E. Bernstein et al., A Bivalent chromatin structure marks key developmental genes in embryonic stem cells, Cell, April 21, 2006. Vincenzo Pirrotta. (The Scientist)
