Metals could forge new cancer drug Oct 19, 2009
" Professor Sadler, at the University of Warwick, commented that he is "excited by the novel design features in these compounds which might enable activity to be switched on and off". Cisplatin was discovered in the 1970s and is one of the most effective cancer drugs on the market, with a 95% cure rate against testicular cancer. Since the success of Cisplatin, chemists all over the world have been trying to discover whether other transition metal compounds can be used to treat cancer. In this... (EurekAlert!)
Improved conditional expression systems resulting in physiological level of HNF4alpha expression confirm HNF4alpha induced apoptosis in the pancreatic beta-cell line INS-1 Oct 18, 2009
As an important result we could extend our previous results that HNF4a induces apoptosis in the pancreatic b-cell line INS-1 with the new aspect that an expression level of the HNF4a transgene marginally exceeding the endogenous level is sufficient to trigger apoptosis. The complete article is available as a. (BioMed Central)
Antibiotic May Be New Stroke Treatment Oct 7, 2009
At low doses it was found to have a neuroprotective effect on neurons by reducing apoptosis of neuronal cells and ameliorating behavioral deficits caused by stroke. According to Dr. Borlongan, "The safety and therapeutic efficacy of low dose minocycline and its robust neuroprotective effects during acute ischemic stroke make it an appealing drug candidate for stroke therapy. An on-going phase 1 clinical study funded by the National Institutes of Health is exploring the use of intravenous... (Science Daily)
New aging studies improving vaccine efficacy for the elderly Oct 6, 2009
The Trudeau team demonstrated that the older cells were relatively resistant to cues that trigger a process known as apoptosis (from the Greek "falling leaves"), a type of orchestrated cell death, and that these cells contained lower levels of a molecule that promotes apoptosis. But even though aged CD4 T cells enjoy longer lives, their function decays. (EurekAlert!)
Experimental Drug Lets B Cells Live And Lymphoma Cells Die Oct 5, 2009
Cell death (apoptosis) is controlled by an intricate network of signals, including toxins, hormones and growth factors like the neurotrophins, which have their effect by interacting with specifically shaped proteins called Trk receptors on cell surfaces. When they dock into their receptors, like ships coming into port, neurotrophins changes the shape of the dock such that chain reactions pass on messages inside the cell. (Science Daily)
Nanoresearchers Challenge Dogma In Protein Transportation In Cells Oct 1, 2009
This process known as "apoptosis" or programmed cell death, is a normal process in the human body. . (Science Daily)
Obesity Alone Does Not Cause Arthritis In Animals, Scientists Find Sep 30, 2009
18, 2005) Disrupted fat cell signaling in obese mice has been linked to increased cell death, or apoptosis, in enlarged hearts. According to the Johns Hopkins researchers who led the study, the research is. (Science Daily)
New Cancer Drug Test Promises Safer And More Effective Clinical Trials Sep 25, 2009
18, 2005) To identify the best treatment for recurrent ovarian cancer, researchers at Yale School of Medicine are studying a technology called the Yale apoptosis assay in combination with another technology. (July 27, 2007) An algorithm that could help rapidly sort molecular information about a cancer patient's particular tumor and could help match this information to the right drug treatment would be a breakthrough of. (Science Daily)
How cell polarity represses tumors Sep 25, 2009
JNK normally promotes apoptosis of scrib mutant cells. However, in cooperation with oncogenic activated Ras or Notch signalling, JNK becomes an essential driver of tumour overgrowth and invasion. (BioMed Central)
The NF-kappa B inhibitor, celastrol, could enhance the anti-cancer effect of gambogic acid on oral squamous cell carcinoma Sep 25, 2009
Many studies have shown that the NF-kappa B signaling pathway plays an important role in anti-apoptosis and the drug resistance of tumor cells during chemotherapy ... The rate of apoptosis was examined with annexin V/PI staining as well as transmission electronic microscopy in Tca8113 cells ... The results showed that GA could inhibit the proliferation and induce the apoptosis of the oral squamous cell carcinoma cell lines and that the NF-kappa B pathway was simultaneously activated by GA... (BioMed Central)
How Proteins Talk To Each Other Sep 24, 2009
D., professor and director of the Apoptosis and Cell Death Research program of Burnham s NCI-designated Cancer Center, and colleagues determined the cleavage sites on target proteins and found, contrary to previous understanding, that caspase-3 targets -helices as well as unstructured loops ... 28, 2006) A protein that triggers apoptosis also plays a part in memory formation ... (May 17, 2008) T cells can initiate cellular suicide, also known as apoptosis, by a previously unrecognized pathway... (Science Daily)
Interferon-α and the Treatment of Leukemia Sep 24, 2009
inhibits growth and promotes apoptosis of many cell types. A recent study by Essers and colleagues2 provides new insight into the effects of interferon. (New England Journal of Medicine)
Inactivating the spindle checkpoint kinase Bub1 during embryonic development results in a global shutdown of proliferation. Sep 23, 2009
This is accompanied by a global shutdown of proliferation, widespread apoptosis and haemorrhaging. Conclusions. (BioMed Central)
Bayer Announces New Data on Oncology Portfolio To Be Presented at the ECCO-ESMO Congress 2009 Sep 17, 2009
Regorafenib has also been shown in preclinical studies to prevent the proliferation of tumor cell lines while promoting apoptosis (cell death) by directly targeting several oncogenic TK receptors. The clinical significance of these studies is not known and warrant further investigation in a broad spectrum of tumors. (PR Newswire)
Yes-associated Protein: Early Diagnosis Of Gastric Carcinoma Sep 17, 2009
Survivin might participate in gastric carcinogenesis, progression and metastasis by inhibiting apoptosis of gastric carcinoma cells and regulating cellular mitosis. Whether YAP and survivin collaborate to contribute to gastric carcinogenesis and progression requires further study. (Science Daily)
What Happens When Immune Cells Just Won't Die? Sep 17, 2009
Snow et al. Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency. Journal of Clinical Investigation, 2009; DOI. (Science Daily)
FDA approves Ascenta Therapeutics trial Sep 11, 2009
It is designed to promote programmed cell death, a process known as apoptosis, in tumor cells by blocking the activity of at least three proteins that inhibit apoptosis. Ascenta licensed the technology from both the National Institutes of Health and the laboratory of Dr. Shaomeng Wang at the University of Michigan. (Philadelphia Business Journal, PA)
Gene Predicts Post-surgical Survival From Brain Metastasis Of Breast Cancer Patients Sep 10, 2009
It also impacts the cell survival process, apoptosis. "Potential therapies would need to turn off this gene and thus starve the tumor of its growth potential," said Palmieri. (Science Daily)
Chlorella Algae, Nutrition Suppleme... Sep 7, 2009
One such study by scientists from South Korea, published in the Journal of Agricultural and Food Chemistry, November 26, 2008, showed evidence that the carotenoids present in chlorella were helpful in preventing cancer, by assuring that cells died when they were supposed to, a process called apoptosis a process that is interrupted by cancer, causing tumorous growth. Another study boosted the survival rate in mice injected with breast cancer cells from zero in the control group, to 70 percent in... (Suite101.com)
Tungstate-induced pancreatic pathways Aug 29, 2009
Treated (STZ)-diabetic rats showed a partial recovery of exocrine and endocrine function, with lower glycemia, increased insulinemia and amylasemia, and increased beta cell mass achieved by reducing beta cell apoptosis and raising beta cell proliferation. The microarray analysis of the pancreases led to the identification of three groups of differentially expressed genes: genes altered due to diabetes, genes restored by the treatment, and genes specifically induced by tungstate in the diabetic... (BioMed Central)
Gene Assay To Help To Predict Lung Cancer Treatment Resistance Aug 28, 2009
Cree said, "The genes identified in this study fall into several categories, linked with much studied mechanisms such as metabolism within the cell, membrane drug pumps, and DNA repair, but also with apoptosis, suggesting that the general susceptibility of the cell to undergo this process may be an important determinant of tumor chemosensitivity, outweighing more specific mechanisms". Journal reference. (Science Daily)
Researchers identify new, cancer-causing role for protein Aug 28, 2009
Akt is a signaling protein that plays a central role in numerous biological functions, including cell growth and programmed cell death, or apoptosis, Lin said. Deregulated Akt expression has been found to contribute to cancer development. (EurekAlert!)
New Therapeutic Target Could Help Patients With Pulmonary Fibrosis Aug 27, 2009
27, 2009) A diagnosis of Idiopathic Pulmonary Fibrosis is not much better than a death sentence: there is no treatment and the survival rate is less than three years. But researchers at the University of Michigan have discovered that targeting of a novel gene utilizing genetic and pharmacologic strategies was successful in treating pulmonary fibrosis in mice and will be developed for future testing in humans. (Science Daily)
Raising The Alarm When DNA Goes Bad: 'Rapid Response Team' Monitors And Quickly Responds To DNA Damage Aug 23, 2009
(June 24, 2008) Cells with irreparable DNA damage normally induce programmed cell death, or apoptosis. However, this mechanism often fails in tumor cells so that transformed cells are able to multiply and spread. (Science Daily)
New Metabolic Safeguards Against Tumor Cells Aug 23, 2009
This process, known as apoptosis, typically stops potential cancer cells before they have a chance to proliferate ... "We originally thought that in order for cells to survive outside their normal environment, they would simply need to suppress apoptosis," says Brugge, senior author on the paper, which will appear August 19 online in Nature ... "But our studies indicate that this activity is not sufficient to prevent the demise of homeless cells. Even if they escape apoptosis, these cells can't... (Science Daily)
Study Supports DNA Repair-blocker Research In Cancer Therapy Aug 21, 2009
It can order them to self-destruct through "programmed cell death," also known as apoptosis ... Instead, they're forced to progress through the cell cycle and, because of their broken DNA, self-destruct through apoptosis. (Science Daily)
Hepatitis C Virus Channels Efforts Into Cell Survival Aug 19, 2009
A study published in the Proceedings of the National Academy of Sciences (PNAS) shows that the virus blocks the actions of a specific ion channel in the cell membrane that would usually trigger apoptosis - the cell's self-destruct programme - and in doing so, has evolved another way of protecting itself from being eliminated from the body. Apoptosis occurs naturally in the body to allow the removal of unhealthy cells or the replacement of worn-out cells ... One of the ways in which apoptosis can... (Science Daily)
Vasohibin inhibits angiogenic sprouting in vitro and supports vascular maturation processes in vivo Aug 17, 2009
Purified murine and human VASH1 protein induced apoptosis of murine fibroblasts in vitro, but not of vascular aortic smooth muscle cells (AoSMC) or endothelial cells. Adenoviral overexpression of murine and human VASH1 inhibited capillary sprouting of HUVECs in the spheroid assay. (BioMed Central)
Scientists Advance Understanding Of Cell Death Aug 17, 2009
Cells in the human body are continually dying and most of these cells kill themselves by a form of cell death, commonly referred to as apoptosis ... Failure of the normal apoptosis process plays a role in different diseases including cancer, certain neurodegenerative disorders such as Parkinson's and immune diseases, such as autoimmune lymphoproliferative syndrome (ALPS) ... Previous research has shown that a complex called the 'DISC', which is made up of different proteins and is formed... (Science Daily)
Finding May Explain Anti-cancer Activity Of Thiazole Antibiotics Aug 16, 2009
Cancer cells have multiple ways to avoid apoptosis, programmed cell death the means by which. (July 5, 2006) Researchers at the University of Minnesota have developed novel anti-cancer drugs to treat solid tumors. (Science Daily)
Viral Mimic Induces Melanoma Cells To Digest Themselves Aug 13, 2009
The researchers went on to show that pIC links autophagy to apoptosis, a well studied cell death pathway ... "First, pIC-PEI can induce both autophagy and apoptosis in an efficient manner while other compounds are just partial inducers of one of the two processes. Second, pIC-PEI has a significant anti-melanoma activity in experimental mouse models without noticeable side effects." The researchers caution that further research is required before these results can be translated to the clinic. (Science Daily)
STAT3 Gene Regulates Cancer Stem Cells In Brain Cancer Aug 12, 2009
It is one of the few genes linked to the propagation of cancer stem cells, and it appears to regulate processes involved in the six hallmarks of cancer: growth, metastasis, angiogenesis, evasion of apoptosis, tissue invasion, and cell immortalization, he continued. The researchers used cancer stem cells isolated from surgically removed samples of glioblastoma tumors. (Science Daily)
Discovery may lead to powerful new therapy for asthma Aug 12, 2009
The untreated cells responded in much the same way airway cells do in an asthma attack, with an increased rate of apoptosis (cell suicide), a jump in the levels of reactive oxygen species, the activation of key "transcription factors" that kick-start the production of inflammatory proteins and the large-scale generation of a whole host of molecules associated with inflammation. Cells treated with aldose reductase inhibitors, by contrast, had a much lower rate of apoptosis, reduced levels of... (EurekAlert!)
Basic Mechanism Of Skin Cancer Development Illuminated Aug 11, 2009
In addition, compared to normal cells, tumour cells have also lost the ability to react to "cell suicide signals" (apoptosis). Cell differentiation decisive for melanoma development. (Science Daily)
Life and death in the living brain Aug 11, 2009
The scientists introduced a chemical into one side of sparrow brains in an area that helps control singing behavior to halt apoptosis, a cell suicide program ... "This is the first demonstration that if you decrease apoptosis you also decrease the number of new brain cells in a live animal. The next step is to understand this process at the molecular level," said Eliot Brenowitz, a UW professor of psychology and biology and co-author of a new study ... They infused the HVC on one side of the... (EurekAlert!)
Unraveling How Cells Respond To Low Oxygen Aug 10, 2009
(July 27, 2009) Scientists have found that the Caspase-8 protein, long known to play a major role in promoting programmed cell death (apoptosis), helps relay signals that can cause cancer cells to proliferate. (Aug. (Science Daily)
Antibody Linked To Chemotherapy Drug Inhibits Ovarian Cancer In Lab Aug 9, 2009
In cell lines, its antitumor effects were also statistically significantly related to decreased proliferation and increased apoptosis of tumor cells. Chemotherapy drugs typically affect both tumor and normal tissues, which can result in side effects. (Science Daily)
Critical Link In Cell Death Pathway Revealed Aug 5, 2009
A team led by Professor Andreas Strasser from the institute's Molecular Genetics of Cancer division has found that XIAP (X-chromosome-linked inhibitor of apoptosis protein) is the critical factor that determines which of two pathways will be followed to culminate in a cell's death. Programmed cell death (also called apoptosis) removes unwanted and dangerous cells from our bodies, protecting us against cancer development and diseases where the immune system attacks the body's own tissues, such as... (Science Daily)
Antibody Targeting Of Glioblastoma Shows Promise In Preclinical Tests Aug 3, 2009
14, 2008) The protein CD95 is known to act as a molecular switch that triggers the apoptosis death program in cells. Scientists have now shown that activation of this switch in glioblastoma has a totally. (Science Daily)
Important Insight Into Apoptosis Or Programmed Cell Death Jul 31, 2009
This process known as 'apoptosis' or programmed cell death, is a normal process in the human body which removes perhaps a million cells a second ... According to Professor Li, they discovered that during apoptosis, the cell's rescue mechanism is inhibited when certain proteins (i ... In addition, they also discovered that the protein RanGTP, which is involved in the transportation of certain proteins into and out of the cell's nucleus, is reduced greatly during the early stages of apoptosis. (Science Daily)
EphA2-targeted therapy delivers chemo directly to ovarian cancer cells Jul 30, 2009
Research has shown that auristatins induce cell cycle arrest at the G - M border, disrupt microtubules and induce apoptosis (programmed cell death) in cancer cells ... They also assessed viability and apoptosis in ovarian cancer cell lines and tumor models and examined anti-tumor activity in orthotopic mouse models with mice bearing HeyA8-luc and SKOV3ip1 ovarian tumors. (EurekAlert!)
Scientists Track Impact Of DNA Damage In The Developing Brain Jul 30, 2009
In a subgroup of those cells, the damage triggered apoptosis, or programmed cell death ... "The cells appear to undergo permanent arrest," said McKinnon, noting it is one of the few in vivo examples of the p53 pathway leading to cell cycle arrest rather than apoptosis. (Science Daily)
Healthy Spices that Fight Cancer Jul 29, 2009
Humphreys,I., et al. Capsaicin Induces Apoptosis in Human Pancreatic Cancer Cells by Activating Mitochondrial Death Pathway. (Presentation at American Association for Cancer Research) Univ. of Pittsburgh Cancer Institute. (Suite101.com)
Protein That Promotes Cancer Cell Growth Identified Jul 27, 2009
ScienceDaily (July 27, 2009) Scientists at Burnham Institute for Medical Research (Burnham) have found that the Caspase-8 protein, long known to play a major role in promoting programmed cell death (apoptosis), helps relay signals that can cause cancer cells to proliferate, migrate and invade surrounding tissues ... Caspase-8 has a well defined role in promoting apoptosis, especially in response to activation of the so-called death receptors on the outside of cells, said Darren Finlay, Ph ...... (Science Daily)
Human cells secrete cancer-killing protein, UK study finds Jul 24, 2009
Funded by several grants from the National Institutes of Health, Rangnekar's study found that when the Par-4 molecule binds to its receptor GRP78 on the surface of a tumor cell, it triggers a biological process called apoptosis or "cell suicide." Consistent with previous research by Rangnekar's laboratory with intracellular Par-4, the newly discovered secreted Par-4 acts selectively against cancer cells, leaving healthy cells unharmed ... However, Rangnekar's most recent study discovered that... (EurekAlert!)
Estrogen Can Reduce Stroke Damage By Inactivating Protein Jul 21, 2009
One change is the activation of another protein called PUMA, which signals a cascading effect that destroys the mitochondria and causes cell death, or apoptosis. Ms. Raz found that estrogen can chemically alter p53 and attenuate the cascade, thus leading to reduced stroke damage. (Science Daily)
Molecules Discovered With A Higher Selective Ability To Exterminate Cancer Cells Jul 21, 2009
The efficiency of the molecules obtained is related to their high capacity to induce apoptosis in cancer cells. Apoptosis is a function of the body that consists of programming the oldest cells' death, as they are no longer useful ... Therefore apoptosis is a mechanism of defence of the body as it also takes place in those cells that are a threat due to failures in their normal activity. (Science Daily)
Fluorescent Probes May Permit Monitoring Of Chemotherapy Effectiveness Jul 18, 2009
If physicians could watch tumor cells committing a form of programmed suicide called apoptosis, a desired effect of workhorse cancer treatments such as chemotherapy and radiotherapy, they could more quickly pick the most effective treatment ... Apoptosis is a carefully orchestrated sequence of intracellular events that leads to the cell's death ... Bogyo is senior author of a study to be published online July 13 in Nature Medicine in which he and his Stanford colleagues demonstrated in mice that... (Science Daily)
A Myc-regulated transcriptional network controls B-cell fate in response to BCR triggering Jul 17, 2009
Here we define the transcriptional changes that underlie BCR-induced apoptosis and proliferation of immature and mature B cells, respectively. Comparative genome-wide expression profiling identified 24 genes that discriminated between the early responses of the two cell types to BCR stimulation. (BioMed Central)
Critical Outcome Technologies Inc. Reports Financial Results for the Fourth Quarter and the Year Ended April 30, 2009 Jul 16, 2009
Experiments conducted in triplicate confirmed that COTI-2 has a profound effect on caspase-9 activation through inhibition of Akt/PKB. The resulting activation of caspase 9 leads to a vigorous apoptosis or programmed cell death in cancer cells. In July 2008 - announced positive preclinical test results for the cellular mechanism of action of COTI-219 and the completion of synthesis of COTI-4A (an analog of COTI-4). (CCNMatthews Press Releases)
McAllister: Old home remedies may get new lives Jul 14, 2009
Capsaicin appears to trigger a biochemical signal that causes fat cells to undergo apoptosis, a mechanism by which cells self-destruct. The results of another animal study published in the Journal of Nutrition revealed that consumption of capsaicin can stimulate fat breakdown in the body. (Green Valley News & Sun, AZ)
Scientists Solve Mystery About Why HIV Patients Are More Susceptible To TB Infection Jul 11, 2009
Patel et al. Impaired M. tuberculosis-mediated apoptosis in alveolar macrophages from HIV persons: potential role of IL-10 and BCL-3. Journal of Leukocyte Biology, 2009; 86 (1): 53 DOI. (Science Daily)
How Mitochondria Get Their Membranes Bent Jul 10, 2009
Cytochrome c, for example, an important signaling protein in programmed cell death (apoptosis), is stored in this compartment ... When apoptosis is triggered, the pores enlarge and cytochrome c is released into the cytosol ... 1, 2006) Scientists at St. Jude Children's Research Hospital have demonstrated that a key event during apoptosis (cell suicide) occurs as a single, quick event, rather than as a step-by-step. (Science Daily)
In space, worms help study microgravity effects Jul 10, 2009
The roundworms showed that they could normally repair their radiation damaged cells in spaceflight by using apoptosis, or the programmed cell death which can also be triggered by unusual amounts of damage. Researchers say that this makes them ideal "living dosimeters" to track accumulated radiation damage over time. (MSNBC -- Technology)
Bioengineers Develop Microfabricated Device To Measure Cellular Forces During Tissue Development Jul 8, 2009
20, 2008) In addition to pruning cells out of the way during embryonic development, the much-studied process of programmed cell death, or apoptosis, has been newly found to exert significant mechanical force. (Nov. (Science Daily)
Novel Light-sensitive Compounds Show Promise For Cancer Therapy Jul 5, 2009
According to Mascharak, one advantage of nitric oxide for cancer treatment is that it induces an orderly type of cell death known as apoptosis. Also known as "programmed cell death," apoptosis does not lead to the inflammation, pain, and swelling normally associated with damage to cells and tissues in the body ... The release of nitric oxide after exposure to light quenched the fluorescence, and the cells showed signs of apoptosis within four to eight hours. (Science Daily)
Early heart attack therapy with bone marrow extract improves cardiac function Jun 30, 2009
Both the cell and cell extract therapies resulted in the presence of more blood vessels and less cardiac cell death, or apoptosis, than no therapy. The study also showed that heart function benefitted despite the finding that few of the injected cells remained in the heart at one month after therapy. (EurekAlert!)
Researchers pinpoint a new enemy for tumor-suppressor p53 Jun 27, 2009
Loss of Trim24 expression in a breast cancer cell line caused spontaneous programmed cell death - apoptosis. A similar response was confirmed in human lung, colon and prostate cancer cells. (EurekAlert!)
Cancer In Humans: Cost Of Being Smarter? Jun 22, 2009
They found distinct differences in the way apoptosis or programmed cell death operates, suggesting that humans do not "self-destroy" cells as effectively as chimpanzees do. Apoptosis is one of the primary mechanisms by which our bodies destroy cancer cells. (Science Daily)
Novel Discovery In Dendritic Cell Signalling Pathways Pave The Way For New Therapeutic Targets Jun 21, 2009
ScienceDaily (June 20, 2009) Scientists from A*STAR's Singapore Immunology Network (SIgN) and the University of Milano-Bicocca, Italy, have discovered another signaling pathway for the activation and apoptosis, or programmed cell death, of dendritic cells[1 ... The scientists also discovered that the entire activation by CD14 was necessary to cause apoptosis ... Activated dendritic cells have a short life span, and scientists have observed that they undergo apoptosis in order to protect the body... (Science Daily)
Gaias Evil Twin: Is life its own worst enemy? by Peter Ward, New Scientist Jun 19, 2009
Autonomous apoptosis. It is life evolving with life, not earth evolving in response to life. (Harper's Magazine)
Protein May Be Strongest Indicator Of Rare Lung Disease, Study Shows Jun 18, 2009
ScienceDaily (June 17, 2009) Researchers at the University of Cincinnati (UC) have discovered a protein in the lungs that can help in determining progression of the rare lung disease Idiopathic Pulmonary Fibrosis (IPF). Researchers say the protein Serum surfactant protein A is superior to other IPF predictors and could lead to better decisions about treatment and timing of lung transplantation. (Science Daily)
Red Wine Compound Resveratrol Demonstrates Significant Health Benefits Jun 16, 2009
" Low doses of resveratrol improve cell survival as a mechanism of cardio- and neuro-protection, while high doses increase cell death. "The key difference is probably the result of activation of the sirtuins in the nucleus," said Brown. "Low activation reverses age-associated changes, while high activation increases the process of apoptosis or programmed cell death to remove cellular debris. Similar changes are seen with low-dose versus high-dose resveratrol: low-dose resveratrol produces... (Science Daily)
Health Secrets of Red Wine Uncovered Jun 16, 2009
High doses of the compound may prevent cancer by increasing the process of apoptosis (programmed cell death). Low doses improve cardiac health by increasing cellular protection and reducing damage. (MEDLINEplus)
How Adrenal Cancer Forms: Dysfunctional Telomeres Can Trigger Cancer Mutations Jun 6, 2009
It was previously unknown whether cellular senescence or programmed cell death -- apoptosis -- was. (Oct. (Science Daily)
