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In a review article published in the June 2009 print issue of The FASEB Journal, scientists from the Mayo Clinic explain how cell receptors (called "death receptors") used by the body to shut down old, diseased, or otherwise unwanted cells (called "apoptosis") may also be used to make cells heartier when facing a wide range of illnesses, from liver disease to cancer. See also. (Science Daily)
How To Get Obese Mice Moving -- And Cure Their Diabetes Jun 3, 2009
18, 2005) Disrupted fat cell signaling in obese mice has been linked to increased cell death, or apoptosis, in enlarged hearts. According to the Johns Hopkins researchers who led the study, the research is. (Science Daily)
Adult Bone Marrow Stem Cells Injected Into Skeletal Muscle Can Repair Heart Tissue Jun 2, 2009
"Injecting MSCs or factors released by MSCs improved ventricular function, promoted myocardial regeneration, lessened apoptosis (cell death) and fibrotic remodeling, recruited bone marrow progenitor cells and induced myocardial expression of multiple growth factor genes," Lee said. "These findings highlight the critical 'cross-talks' between the injected MSCs and host tissues, culminating in effective cardiac repair for the failing heart.". (Science Daily)
Bayer Announces New Data on Novel Anti-cancer Compound BAY 73-4506 May 31, 2009
BAY 73-4506 has also been shown in preclinical studies to prevent the proliferation of tumor cell lines while promoting apoptosis (cell death) by directly targeting several oncogenic TK receptors. The clinical significance of these studies is not known and warrant further investigation in a broad spectrum of tumors. (PR Newswire)
Proteolix Presents Phase 1b/2 Clinical Data for Carfilzomib in Advanced Solid Tumor Patients at the 2009 ASCO Annual Meeting May 31, 2009
Carfilzomib produces specific and sustained inhibition of the proteasome, leading to apoptosis in cancer cells with minimal off-target effects. In Phase 1 and Phase 2 clinical trials, carfilzomib has demonstrated single-agent activity in hematologic malignancies and solid tumors, including multiple myeloma, Waldenstrom's macroglobulinemia, mantle cell lymphoma, and renal cell carcinoma. (PR Newswire)
Oncothyreon announces clinical data from three product candidates presented at American Society of Clinical Oncology (ASCO) Annual Meeting May 30, 2009
Aberrant activation and regulation of PI-3 kinase is implicated in a large proportion of human cancers including breast, glioma, colon, ovarian, prostate and melanoma, where it leads to increased proliferation and inhibition of apoptosis (programmed cell death). PX-866 has been shown to induce prolonged inhibition of tumor PI-3 kinase signaling following both oral and intravenous administration. (Canada Newswire)
Regulation of neuronal migration May 28, 2009
AP-2a is a transcription factor essential for neural crest cell migration and its mutation results in apoptosis within this cell population as demonstrated by genetic models. Results. (BioMed Central)
A potential drug for liver carcinoma May 23, 2009
The apoptosis of HepG2 cells was determined by flow cytometry using propidium iodide fluorescence staining ... Reference: Tan XW, Xia H, Xu JH, Cao JG. Induction of apoptosis in human liver carcinoma HepG2 cell line by 5-allyl-7-gendifluoromethylenechrysin. (EurekAlert!)
T cells cooperate with palmitic acid in induction of beta cell apoptosis May 23, 2009
ConA-stimulated LNC or Sn and PA cooperated in inducing caspase-3-dependent RIN cell apoptosis. The observed effect of PA and Sn on RIN cell viability was mediated by p38 mitogen-activated protein kinase (MAPK)-signaling and was achieved through auto-destructive nitric oxide (NO) production. (BioMed Central)
Viral Genetics Has Option Under Issued Key Patent for Cancer Drug May 22, 2009
Disrupting these metabolic pathways can cause apoptosis of the cancer cells without significant adverse effect on non-cancer cells. Viral Genetics' approach addresses one of the primary reasons chemotherapy and radiation are not always effective - the development of drug resistance. (PR Newswire)
Derivative Of Red Sea Coral May Fight Skin Cancer May 18, 2009
The SDSU study also showed that sarcophine-diol induced apoptosis, or programmed cell death, in cancer cells. The extent of apoptosis observed in different treatments in the study was correlated to the level of sarcophine-diol used, Dwivedi said ... The SDSU experiment also looked at whether sarcophine-diol treatments could increase what is called DNA fragmentation, considered a biochemical hallmark of apoptosis an indication that the cell is committed to die, in other words. (Science Daily)
Red sea coral treats skin cancer May 17, 2009
It also induced apoptosis, or programmed cell death, in cancer cells. Dwivedi said that the extent of apoptosis observed in different treatments in the study was correlated to the level of sarcophine-diol used ... The study found that treatments with higher concentrations of sarcophine-diol induced higher level of so-called "executioner" proteins that have a role in apoptosis, or programmed cell death compared to a control group. (India Times, India)
Trubion Announces Acceptance of Three Presentations on Its TRU-016 Product Candidate at the 2009 ASCO Annual Meeting May 15, 2009
Preclinical Mechanism Apoptosis in CLL Cells Occurs Via Distinct Mechanism Compared With Other Therapeutics ... The presentations will include positive data from a Phase 1 clinical trial of TRU-016 for the treatment of chronic lymphocytic leukemia (CLL), a preclinical study demonstrating the additive or synergistic effects of TRU-016 in combination with other therapeutic drugs for the treatment of non-Hodgkin's lymphoma (NHL), and a preclinical study evaluating the effect of TRU-016 on direct... (PR Newswire)
Medicinal Plant, St John's Wort, May Reduce Neuronal Degeneration Caused By Parkinson's Disease May 14, 2009
St John's wort reduces the exacerbated production of Reactive oxygen species produced in the presence of Rotenone, as well as the damage that the free radicals cause dopaminergic neurons in the substantia nigra, avoiding the action of apoptosis. The neuron protecting effects are greater with the standard Hypericum Perforatum extract with the 0. (Science Daily)
Level Of Cellular Stress Determines Longevity Of Retinal Cells May 10, 2009
In their work, Hermann Steller, head of the Strang Laboratory of Apoptosis and Cancer Biology, and C;sar Mendes, a former graduate student in the lab, genetically turned on three known cell death signals in fruit fly retinal cells, each of which directs the cell to undergo a process of controlled suicide. But when they knocked out a gene called NinaA, they saw that the cells halt their descent toward death. (Science Daily)
Method To Neutralize Tumor Growth In Embryonic Stem Cell Therapy Discovered May 8, 2009
By neutralizing the activity of survivin in the undifferentiated cells as well as in the tumors, the researchers were able to initiate programmed cell death (apoptosis) in those cells. This inhibition of this gene just before or after transplantation of the cells could minimize the chances of tumor formation, but the researchers caution that a combination of strategies may be needed to address the major safety concerns regarding tumor formation by human embryonic stem cells. (Science Daily)
Notch1 Contributes To Scar Tissue In The Lungs May 6, 2009
3, 2004) A research team at Yale has found that blocking a kind of cell death called apoptosis in fibrotic diseases of the lung, also blocks the fibrosis, opening new ways of looking at treatment for lung. (Nov. (Science Daily)
An iron-based beverage, HydroFerrate Fluid (MRN-100), alleviates oxidative stress in murine lymphocytes in vitro May 3, 2009
The present study was carried out to examine the protective effects of MRN-100 against stress-induced apoptosis in murine splenic cells in vitro ... Results: Results show, as expected, that culture of splenic cells with H2O2 alone results in a significant increase in cell death (apoptosis) as compared to control (CM) cells ... In contrast, pre-treatment of cells with MRN-100 followed by H2O2 treatment results in significantly reduced levels of apoptosis. (Nutrition Journal)
Daptomycin in experimental murine pneumococcal meningitis May 1, 2009
Caspase-3 staining was used to assess apoptosis on brain histopathology ... The amount of apoptosis of brain parenchymal cells was equivalent among treatment groups. (BioMed Central)
Upside-down World: DNA Protecting Protein Helps Cancer Drug To Kill Cells Apr 30, 2009 Telik Reports Preclinical Results at AACR Annual Meeting Apr 29, 2009 Use of Human Milk As Cancer Therapy Apr 28, 2009 New biomarker may predict leukemia aggressiveness Apr 20, 2009 Brain metastases hijack neuron-supporting cells to resist chemotherapy Apr 20, 2009 Cyclacel Pharmaceuticals Announces Multiple Presentations At American Association of Cancer Research Annual Meeting Apr 16, 2009 New therapeutic target for melanoma identified Apr 16, 2009 Angiotensin-Receptor Blockers for Prevention of Atrial Fibrillation — A Matter of Timing or Target? Apr 16, 2009 Colon Cancer Shuts Down Receptor That Could Shut It Down Apr 15, 2009 For cancer cells, genetics alone is poor indicator for drug response Apr 13, 2009 CSHL-led team identifies key decision-point at which cells with broken DNA repair themselves or die Apr 11, 2009 Fibrosis and Myocardial Infarction Apr 9, 2009 Cellular Target May Prove Useful In Treating Deadly Brain Tumors Apr 7, 2009 alpha-Sarcin catalytic activity is not required for cytotoxicity Apr 4, 2009 Time (and PPAR-beta/delta) Heals All Wounds Mar 30, 2009 Discovery May Result In New Test To Determine Predisposition To Cancer Mar 26, 2009 Cancer Medication? Potential Tumor Suppressor Identified Mar 25, 2009 Lung Cancer: Molecular Scissors Determine Therapy Effectiveness Mar 25, 2009 Genetic Mechanism In Mole Rats Can Be Targeted In Cancer Research Mar 24, 2009 Natural cytotoxic agent against bladder cancer Mar 19, 2009 Small Molecules Block Cancer Gene Mar 18, 2009 MicroRNA undermines tumor suppression Mar 18, 2009 Hepatitis C: Key Molecules That Inhibit Viral Production Identified Mar 17, 2009 Phylonix granted broad US patent for assessing cardiac functions in zebrafish Mar 16, 2009 Alzheimer's disease therapeutic prevents long-term damage from TBI in pre-clinical studies Mar 16, 2009 Why Anesthesia Is Associated With Cognitive Impairment And Risk Of Alzheimer's Disease Mar 13, 2009 Antioxidants In Midwestern Black Raspberries Influenced By Where They Grow Mar 12, 2009 Characterization of STAT3 activation and expression in canine and human osteosarcoma Mar 11, 2009 Veggie diet 'cuts prostate cancer risk' Mar 7, 2009 New Clues About Mitochondrial 'Growth Spurts' Mar 5, 2009 Inactivity leads to quick muscle loss Mar 3, 2009 Caffeine may kill some skin cancer cells Feb 27, 2009 Two sisters at Bartow High among state science fair qualifiers Feb 26, 2009 Revolutionary New Model For Alzheimer's Disease Feb 21, 2009 * New use found for diabetes medicine Feb 21, 2009 Genentech, Buck Institute research could flip Alzheimers programs Feb 20, 2009 Role of oxidative stress and intracellular glutathione in the sensitivity to apoptosis induced by proteasome inhibitor in thyroid cancer cells Feb 16, 2009 The effect of the dual Src/Abl kinase inhibitor AZD0530 on Philadelphia positive leukaemia cell lines Feb 14, 2009 Rapid glycation with D-ribose induces globular amyloid-like aggregations of BSA with high cytotoxicity to SH-SY5Y cells Feb 13, 2009 Beginners Luck, or Creative Artists of the First Rank? Epeius Biotechnologies Launches Rexin-G eBook Tutorial Feb 13, 2009 Inflammation In Colon May Get Doused Before Fueling Cancer Development Feb 11, 2009 Cell Research Feb 8, 2009 Nature Reviews Drug Discovery Feb 8, 2009 Nature Immunology Feb 8, 2009 Cancer Gene Therapy Feb 8, 2009 Scattered Light Rapidly Detects Tumor Response To Chemotherapy Feb 7, 2009
(June 24, 2008) Cells with irreparable DNA damage normally induce programmed cell death, or apoptosis. However, this mechanism often fails in tumor cells so that transformed cells are able to multiply and spread. (Science Daily)
Tuberculosis is forgotten, but not gone Apr 29, 2009
Biologists call this self-destruct sequence apoptosis, but large amounts of carbon monoxide can shut it down ... We don t yet know how the TB dormancy genes work in humans or what else happens inside the body, Steyn said, but the hypothesis is that if people inhale large amounts of carbon monoxide from cigarettes or indoor air pollution that may shut down apoptosis in those macrophages and induce reactivation of TB.. (Racine Journal Times, WI)
Inhibition of Aurora kinase activity induces growth arrest and apoptosis in cells and leads to tumor-growth inhibition in xenograft models of human cancer ... These compounds induced growth arrest, polyploidy and apoptosis in human cancer cell lines, such as HCT116 (colon), HL60 (promyelocytic leukemia) and A549 (lung) - reflecting cell lines with intact or defective p53-dependent post-mitotic checkpoints ... The resulting apoptosis or senescence of these cells may depend on their p53 status. (PR Newswire)
This is supported by a study published in 1995 from Lund University in Sweden that showed that human milk could cause cultured cancer cells to undergo programmed cell death, or apoptosis ... While no studies have tested the ability of human milk to stimulate cancer cell apoptosis in human patients, many people that have been diagnosed with cancer are encouraged by these results and choose to use breast milk as a complement or to conventional cancer treatment. (Suite101.com)
"This implies that if we can develop drugs to block this enzyme, which would raise cAMP and promote apoptosis which is really at the heart of the underlying pathology.". . (EurekAlert!)
Both drugs induced apoptosis, or programmed cell death. When the cells were collected with astrocytes, cell death dropped to levels seen when there was no drug applied to the cancer cells at all. (EurekAlert!)
Sapacitabine "Synergistic interactions between sapacitabine (CYC682) and inhibitors of either histone deacetylase or methyltransferase in Acute Myeloid Leukemia cell lines" Date/Time: Tuesday, Apr 21, 2009, 1:00 PM - 5:00 PM Mountain Time Abstract Number: 4552 Seliciclib "Targeting the cyclin E-Cdk2 complex represses lung cancer growth by triggering apoptosis and anaphase catastrophe" Date/Time: Tuesday, Apr 21, 2009, 3:40 PM Mountain Time Abstract Number: 4784 "Derivatives of seliciclib with... (Primezone Releases)
(PHILADELPHIA) A protein called Mcl-1 plays a critical role in melanoma cell resistance to a form of apoptosis called anoikis, according to research published this week in Molecular Cancer Research ... The Bcl-2 family includes several prosurvival proteins that are associated with the resistance of cancer cells to apoptosis, or cell death. (EurekAlert!)
2,3,4 Apoptosis and interstitial fibrosis develop over the longer term and are usually irreversible. 2,3,4. (New England Journal of Medicine)
The receptor puts a double-whammy on cancer by sending signals that trigger cell death, or apoptosis, and shutting down a protein that causes inflammation, a precursor to cancer. "We know the receptor is silenced in cancer but it's not like the gene goes away," says Dr. Vadivel Ganapathy, corresponding author and chair of the Department of Biochemistry and Molecular Biology in the MCG School of Medicine. (Science Daily)
In order to investigate this disparate behavior among cells, graduate student Sabrina Spencer and postdoctoral researcher Suzanne Gaudet, both in Sorger's lab, looked at a molecule called TRAIL, a protein that causes cells to, literally, commit suicidea process scientists call apoptosis ... "Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis". (EurekAlert!)
When cells undergo potentially catastrophic damage, for example as a result of exposure to ionizing radiation, they must make a decision: either to fix the damage or program themselves for death, a process called apoptosis ... D., of the Tonks lab, showed that when Eyes Absent was not present in damaged cells grown in culture, such foci were not formed and the cells went the route of apoptosisthey programmed themselves to die ... When EYA was experimentally "knocked out" via a technique called... (EurekAlert!)
The wound, caused by necrosis and apoptosis after coronary-artery occlusion, triggers the healing process, resulting in a strong fibrotic scar and the restoration of pump function. Healing is accomplished through. (New England Journal of Medicine)
A constitutively active form of neurokinin 1 receptor and neurokinin 1 receptor-mediated apoptosis in glioblastomas. Journal of Neurochemistry, 2009; DOI. (Science Daily)
This is important since recent studies have cast doubt on whether protein synthesis inhibition is sufficient to initiate apoptosis. Results. (BioMed Central)
But cultured keratinocytes from these mice don't proliferate any faster than normal cells and, in fact, are more susceptible to apoptosis (2). According to Nguan Soon Tan, this discrepancy was the first indication that PPAR / might regulate crosstalk between layers of the skin the epidermal hyperproliferation seen in the knockout mice could be due to faulty signals from the dermal cells. (Science Daily)
18, 2005) To identify the best treatment for recurrent ovarian cancer, researchers at Yale School of Medicine are studying a technology called the Yale apoptosis assay in combination with another technology. (Jan. (Science Daily)
When this gene mutates to an oncogene, the cell proliferates excessively and apoptosis is inhibited. Thereby the gene plays a decisive role in the development of many tumors. (Science Daily)
14, 2008) The protein CD95 is known to act as a molecular switch that triggers the apoptosis death program in cells. Scientists have now shown that activation of this switch in glioblastoma has a totally. (Science Daily)
In the past it has also been revealed that VEGF (Vascular Endothelial Growth Factor - a major growth factor that regulates the growth of new blood vessels) and p53 (a "master" gene, responsible for activating a battery of other genes engaged in either programmed cell death [apoptosis] or DNA-repair in cells) exhibit a similar mode of action in mole rats and in cancer growths, which is why they are so destructive in human cancer growths, Prof. Avivi pointed out. (Science Daily)
Comprehensive gene expression analysis confirmed that frankincense oil activates genes that are responsible for cell cycle arrest, cell growth suppression, and apoptosis in J82 cells. However, frankincense oil-induced cell death in J82 cells did not result in DNA fragmentation, a hallmark of apoptosis. (BioMed Central)
Three of the six worked to induce programmed cell death or apoptosis in breast cancer cell lines. "It induced death in those breast cancer cells that depend for their survival on Stat3," said Tweardy. (Science Daily)
When Le reduced the amount of miRNA125b in the cells, p53 levels and the number of cells undergoing apoptosis (a type of programmed cell death that can be triggered by p53) both increased, whereas an increase in miRNA125b levels decreased levels of p53 and the number of apoptotic cells ... When she reduced miRNA125b levels in the embryos, cellular p53 levels and apoptosis both increased. (EurekAlert!)
Core, the most conserved protein among all HCV genotypes, plays several essential roles in the viral cycle in the host cell; studies have suggested that these core-core or core-other protein interactions can modulate various functions including signaling, apoptosis or programmed cell death, lipid metabolism, and gene transcription. The core protein is particularly important in the assembly of the hepatitis C nucleocapsid, an essential step in the formation of infectious viral particles; the... (Science Daily)
"Our panel of zebrafish-based assays will bridge this gap by enabling thorough assessment of cardiotoxicity during early stages of drug development. "This award complements our previously issued patents for assessing angiogenesis, apoptosis, and toxicity in zebrafish, use of high-throughput screening methods, and transplantation of human cells for drug testing and disease modeling," she continued. Advantages of Zebrafish for Assessing Cardiotoxicity The two-chamber zebrafish heart develops... (EurekAlert! -- Business News)
This damage comes from apoptosis, which is a different form of cell death, and can result in large holes in brain tissue that cause lasting neurological effects. To date, there has been no way to prevent or treat this damage, he says. (EurekAlert!)
1, 2005) In a new study, researchers show that a processed form of tau protein induces neuronal death by apoptosis (programmed cell death) when expressed in cultured rat hippocampal neurons. Pathological. (Science Daily)
Anthocyanins, a class of flavonoids in black raspberries, inhibited growth and stimulated apoptosis in the esophagus. (May 2, 2002) There is a potentially powerful biological weapon for health -- a mix of compounds suspected of thwarting colon cancer -- hiding deep inside the juicy sweetness of a black raspberry. (Science Daily)
To examine STAT3 and Src expression in OSA, we performed Western blotting and RT-PCR. OSA cells were treated with either STAT3 siRNA or small molecule Src (SU6656) or STAT3 (LLL3) inhibitors and cell proliferation (CyQUANT), caspase 3/7 activity (ELISA), apoptosis (Western blotting for PARP cleavage) and/or viability (Wst-1) were determined ... In both canine and human OSA cell lines, downregulation of STAT3 activity through inhibition of upstream Src family kinases using SU6656, inhibition of... (BioMed Central)
They may suppress angiogenesis, induction of apoptosis and down-regulation of hormone receptors expression. Overall there is some evidence suggesting that consumption of legumes, including soy and soy products, is protective against CaP.. (India Times, India)
Bcl-xL belongs to the Bcl-2 protein family, whose members can protect mitochondria or shatter them to drive apoptosis. Berman et al.'s results suggest that Bcl-xL manages the number, size, and energy-producing capacity of mitochondria long before the cell is faced with a life-or-death decision. (Science Daily)
During chronic muscle inactivity, he said, a process called autophagy - or type 2 cell death - joins with apoptosis - or type 1 cell death - in attacking cells and causing muscles to shrink. Muscle inactivity leads to big increases in the proteins LC3 and Beclin 1 in the body, O'Leary said. (India Times, India)
Adding caffeine seems to stimulate more cells into triggering their suicide sequence (called apoptosis) while only about 1 out every 500 cells will undergo apoptosis when exposed to UV, about 1 out of every 200 do when caffeine enters the picture, Nghiem told LiveScience. By examining the in human cells (for the first time), Nghiem and his colleagues determined that ATR was caffeine's target in the cell. (MSNBC -- Health)
Pranali won for a biochemistry project titled Characterization of a Biophysics Simulation to Evaluate p53 Apoptosis. Prachiti won for her medicine and health project titled Determination of Amyloid-Beta levels through regulation of Ataxin-1 Pathway. (Lake Wales News, FL)
We believe that Alzheimer s disease is somewhat analogous to cancer, which results from an imbalance between the normal processes that support cell survival and those that cause cell turnover, said Patrick Mehlen, PhD, Director of the Apoptosis, Cancer and Development CNRS Laboratory at the University of Lyon and co-senior author of the study. Our hope is that this research will lead to therapeutics that will be used to address this imbalance much earlier in the disease process. (Science Daily)
We discovered that the increase of protein 14-3-3E that is related to nuclear receptor PPAR can decrease apoptosis, which is an important mechanism for protecting cells during a stroke, National Health Research Institute president Kenneth Wu (O) said ... This will help protect cells and decrease instances of apoptosis [cell death], Wu said. (Taipei Times, Taiwan -- Sports)
Patrick Mehlen, director of the Apoptosis, Cancer and Development CNRS Laboratory at the and co-senior author of the study, said the Buck-French team believes Alzheimer s is somewhat analogous to cancer, which results from an imbalance between the normal processes that support cell survival and those that cause cell turnover. Our hope is that this research will lead to therapeutics that will be used to address this imablance much earlier in the disease process, Mehlen said in a press release. (Bizjournals.com)
At concentrations that effectively inhibited proteasome activity, bortezomib induced apoptosis in FRO cells, but not in ARO cells ... Furthermore, depletion of GSH increases apoptosis induced by bortezomib, in contrast, repletion of GSH decreases bortezomib-mediated cell death ... GSH protects cells from proteasome inhibition-induced oxidative stress and glutathione-dependent redox system might play an important role in the sensitivity to proteasome inhibition-induced apoptosis. (BioMed Central)
Cell proliferation, apoptosis, survival and signalling pathways were assessed by dye exclusion, flow cytometry and Western blotting respectively ... AZD0530 specifically inhibited the growth of, and induced apoptosis in CML and Ph+ ALL cells in a dose dependent manner, but showed only marginal effects on Ph- ALL cells. (BioMed Central)
As observed by Hoechst 33258 staining, 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and cell counting kit-8 (CCK-8) assay, lactate dehydrogenase (LDH) activity assay, flow cytometry using Annexin V and Propidium Iodide staining and reactive oxygen species (ROS) measurements, the amyloid-like aggregation of glycated BSA induced apoptosis in the neurotypic cell line SH-SY5Y.. Conclusions. (BioMed Central)
As one watches the artful collapsing of a tumor under the onslaught of the targeted genetic medicine, it is interesting to note that the complex mechanisms of cellular apoptosis, focal necrosis, and anti-angiogenesis were beautifully "translated" by a Native American artist/programmer by visualizing and digitizing time-lapse photography that revealed the collapsing of a pumpkin in a field. Likewise, the interactive booklet is a magical work of electronic storytelling, utilizing video stills,... (PR Newswire)
Cancer is often characterized as an uncontrolled growth in our bodies, but scientists now say that a natural process of cell death, or "apoptosis," is also critically important in cancer, Turner said ... "We were able to decrease the number of cells that were proliferating in the colon. And we were able to increase the number of cells that were undergoing apoptosis. So the net effect of that is, we were able to maintain almost a normal number of cells.". (Science Daily)
Spanning the journal's scope, these articles highlight the latest within cell growth and differentiation, signal transduction, apoptosis, stem cells, development, immunology, neurosciences, plant cell biology, chromatin modulation, epigenetics and transcription. In three consecutive issues starting from the March 2008 issue, Cell Research presents a series of reviews on the recent advances in many important frontiers of signal transduction in the context of stem cell self-renewal and... (Nature News Service)
Apoptosis, the major form of controlled cell death, has a key role in the pathogenesis of diseases including cancer, inflammation and neurodegenerative disorders. This special focus highlights innovative therapeutic strategies targeting apoptosis and agents in clinical trials, and discusses the challenges in realizing their potential. (Nature News Service)
The mechanism by which cytokines suppress Bax activation and eosinophil apoptosis are not well understood. Malter and colleagues pinpoint a function for the peptidyl-prolyl isomerase Pin1 in mediating cytokine-induced suppression of Bax activation. (Nature News Service)
It publishes original laboratory and clinical research papers, case reports and review articles on topics including RNAi approaches, drug resistance, hematopoietic gene transfer, homologous recombination, ribozyme technology, antisense technology, tumor immunotherapy and tumor suppressors,translational research, cancer therapy, gene delivery systems (viral and non-viral), anti-gene therapy (antisense, siRNA ymes), apoptosis; mechanisms and therapies, vaccine development, immunology and... (Nature News Service)
Most chemotherapy drugs work by forcing cancer cells to commit cellular suicide, a process known as apoptosis ... "The new technology allowed us to detect the tell-tale signs of apoptosis in human breast cancer cells in as little as 90 minutes," said Adam Wax, associate professor of biomedical engineering and senior member of the research team ... "The fact that the changes in structure appear over two distinct time scales suggests that multiple mechanisms are involved in these early events in... (Science Daily)
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